Impact of radiation therapy fraction size on local control of early glottic carcinoma

Hypofractionated Radiation with concurrent Cisplatin plus Erlotinib in locally advanced squamous cell carcinomas of head and neck: A Feasibility Phase II Study of a Single Institute

“…In this study, grade 3 and 4 acute toxicities especially mucositis, skin reaction and dysphagia were high which is almost concordance with previous studies [17,18] .…”

Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital Experience

“…Treatment related parameters that may have an effect on end results include overall treatment time (OTT) [6,16,27,33,40,41,42,49,51], fraction size [20,22,29,43,54] [42]. Even with surgical salvage, the group of patients whose treatment was most prolonged had an increased risk of death from loco-regional progression of disease.…”

Hypofractionated accelerated radiotherapy in T1–3 N0 cancer of the larynx: A prospective cohort study with historical controls

“…12,18,[22][23][24][25] In some reports these indicators reach 100%. 2,13,26 The publications on hypofractionated accelerated RT for larynx cancer present results in T1-T2 tumors while in our study T3 tumors were diagnosed in 8% of patients in the H group.…”

“…13 Also, Yu et al reported better results in a hypofractionated group (2.25-2.5 Gy) as compared to a standard 2.0 Gy fractionation. 25 Rudoltz et al found that fraction dose ≥2.0 Gy was more effective for local control than doses <2.0 Gy. 27 Ermis et al reviewed results of 10 published series of hypofractionated RT for T1 and T2 tumors and found 5-year local control of 61-89% in T2.…”

“…No difference in toxicity between standard and hypofractionated protocols was found in published reports of hypofractionated RT of the laryngeal cancer. 11,13,18,22,23,25 In majority of these reports a fraction dose of 2.25-2.5 Gy was used. The dose >3.0 Gy was linked to a higher complications rate, 13,34 but in a group of 200 patients reported by Gowda et al in which 3.12-3.28 Gy doses were used for 3 weeks up to a total of 50-52.5 Gy, early and late toxicity were low.…”