Impact of radiotherapy on circulating lymphocyte subsets in patients with esophageal cancer

Lv, Yajuan; Song, Meijuan; Tian, Xiufang; Yv, Xinshuang; Liang, Ning; Zhang, Jiandong

doi:10.1097/md.0000000000020993

Cited by 15 publications

(11 citation statements)

References 32 publications

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“…This is largely consistent with the ndings of Hu et al (Hu et al 2012). Chemoradiotherapy not only kills tumor cells, but also causes various degrees of killing and inhibition of normal cells (Lv et al 2020;Sage et al 2016). Besides, different lymphocyte subsets showed different sensitivity to chemoradiotherapy, which may account for the elevated levels of CD8 + T lymphocytes and NK lymphocytes (Cesaire et al 2020).…”

Section: Discussionsupporting

confidence: 84%

WITHDRAWN: Prognostic significance of circulating lymphocyte subsets in patients with nasopharyngeal carcinoma

Shen

Yan

Lan

et al. 2021

Preprint

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Objective The purpose of this study was to explore the prognostic value of circulating lymphocyte subsets in patients with nasopharyngeal carcinoma (NPC) before treatment and the impact of chemoradiotherapy on lymphocyte subsets. Methods 934 patients with non-metastatic nasopharyngeal carcinoma were analyzed retrospectively. The percentage of circulating lymphocyte subsets was detected by flow cytometry and analyzed retrospectively. The correlation between lymphocyte subsets and prognosis was evaluated by the log-rank test and Cox proportional hazards model, and the differences of lymphocyte subsets before and after chemoradiotherapy was comparing by the paired t-test and Wilcoxon signed rank test. Results Univariate and multivariate analyses indicated that high CD19+ B lymphocytes (HR 0.705, 95%CI 0.519–0.958, P = 0.026) and CD4+ T lymphocytes (HR 0.560, 95%CI 0.331–0.946, P = 0.030) before treatment were independent favorable prognostic factors for overall survival (OS) and distant metastasis-free survival (DMFS) in NPC patients, respectively. After chemoradiotherapy, the percentage of CD3+ T lymphocytes, CD4+ T lymphocytes, CD4/CD8 ratio and CD19+ B lymphocytes decreased significantly, while the percentage of CD8+ T lymphocytes and NK lymphocytes increased significantly. Conclusion Patients with high CD19+B lymphocytes and CD4+T lymphocytes have a better prognosis, and perhaps the immune response can be improved to make the prognosis better by increasing the number of lymphocyte subsets. Chemoradiotherapy may reduce the immune function of patients with nasopharyngeal carcinoma.

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Section: Discussionsupporting

confidence: 84%

WITHDRAWN: Prognostic significance of circulating lymphocyte subsets in patients with nasopharyngeal carcinoma

Shen

Yan

Lan

et al. 2021

Preprint

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“…Our results are consistent with others. 4 , 32 In short, these data suggest that CD4/CD8 ratio can generally reflect the immune status of tumor patients, and can provide auxiliary reference for doctors.…”

Section: Discussionmentioning

confidence: 82%

Aberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy

Lan

et al. 2021

Technol Cancer Res Treat

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Purpose: The role of different circulating lymphocyte subsets, as well as their correlation with clinical characteristics of small cell lung cancer patients have not yet been fully understood. This study aims to evaluate the influence of the fluctuating absolute numbers of lymphocyte subpopulations in peripheral blood of patients with small cell lung cancer. Methods: The absolute counts and percentages of lymphocyte subsets in peripheral blood of 329 patients with small cell lung cancer were retrospectively analyzed. The numbers of CD3+, CD3+CD4+, and CD3+CD8+ T lymphocytes, CD3−CD19+ B lymphocytes, and CD3−CD16+CD56+ NK cells were evaluated by flow cytometry. Their relationship with the patients’ clinical characteristics were statistically evaluated. Results: The CD4/CD8 values derived from the absolute number and percentage of CD3+CD4+ cells divided by CD3+CD8+ cells were identical (1.86 ± 0.99). There was no association between any of the lymphocyte subsets levels and age/sex of the 329 patients with small cell lung cancer. The patients with advanced stage had a reduction in CD3+ and CD3+CD4+ T cell counts and a decreased CD4/CD8 ratio. The levels of CD3+CD4+ T cells, CD3−CD19+ B cells, CD3−CD16+CD56+ NK cells, and CD4/CD8 ratio were associated with advanced tumor-node-metastasis stage. Patients who had undergone radiotherapy were characterized by lymphopenia with lower numbers of CD3+, CD3+CD4+, CD3+CD8+ T lymphocyte, B lymphocyte, NK cell, and CD4/CD8 ratio. The evaluation of individual CD4/CD8 ratio should be combined with other clinical parameters. Conclusions: Patients with small cell lung cancer have altered lymphocyte homeostasis. Lymphopenia was a long-lasting feature of the enrolled patients who were treated with radiotherapy. The available lymphocyte subsets levels might be used to manage the clinical treatment scheme.

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“…The number of peripheral T cells was found to decrease at 4 hours after the administration of prednisone, which returned to baseline at 24 hours ( 25 ). Similarly, patients with esophageal cancer after radiotherapy also showed a decreased circulating lymphocyte count with an increased proportion of T cells but a decreased proportion of NK cells and B cells ( 26 ). The impact of chemotherapy on circulating lymphocyte subsets has been examined previously.…”

Section: Discussionmentioning

confidence: 99%

Changes of proportions of circulating lymphocyte subsets in cancer patients after chemotherapy

Wang¹,

Wang²,

Cao³

2021

Transl Cancer Res TCR

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Background It remains unknown how chemotherapy affects circulating lymphocyte subsets and whether the pattern of change is related to prognosis in cancer patients. Methods Cancer patients who received chemotherapy between 2018/03/01 and 2019/12/31 were enrolled from the Hefei Cancer Hospital, Chinese Academy of Sciences. Peripheral blood samples were collected before and 3 weeks after the start of chemotherapy, and the proportions of T cells (CD3+), helper T cells (CD3+CD4+), cytotoxic T cells (CD3+CD8+), B cells (CD19+), and Natural killer (NK) cells (CD3−CD56+) were examined by flow cytometry. Multivariable logistic regression analysis was employed to explore risk factors associated with overall survival within 12 months after the start of chemotherapy. Results A total of 167 patients with cancer were included in the analysis, including 14 cases of cervical cancer, 18 cases of breast cancer, 33 cases of gastric cancer, 48 cases of lung cancer, 21 cases of colorectal cancer, and 33 cases of esophageal cancer. The proportion of T cells (72.58%±10.44% vs. 80.67%±11.63%, P<0.001) and cytotoxic T cells (25.38%±8.87% vs. 39.20%±12.26%, P<0.001) significantly increased, while the proportion of helper T cells (45.58%±10.19% vs. 41.98%±10.47%, P<0.001), B cells (15.10%±5.23% vs. 11.29%±5.60%, P<0.001), and NK cells (19.33%±7.54% vs. 18.28%±7.62%, P<0.001) significantly decreased at 3 weeks after chemotherapy when compared to baseline levels. The overall mortality rate was 14.97% (25/167) within 1 year after the start of chemotherapy. Patients who survived showed a significantly less increase in cytotoxic T cells (13.38%±8.28% vs. 17.28%±7.97%, P=0.030) and less decrease in B cells (−3.58%±2.81% vs. −5.29%±3.03%, P=0.006) when compared to non-survivors. Greater decreases in helper T cells (OR 0.81, 95% CI, 0.68–0.96) and B cells (OR 0.72, 95% CI, 0.59–0.87), and a greater increase in cytotoxic T cells (OR 1.09, 95% CI, 1.03–1.16) were risk factors for poor overall survival. Conclusions Circulating lymphocyte subsets of cancer patients presented characteristic changes after chemotherapy. Patients with a greater decrease in helper T cells and B cells, or greater increase in cytotoxic T cells, may have worse survival.

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Impact of radiotherapy on circulating lymphocyte subsets in patients with esophageal cancer

Cited by 15 publications

References 32 publications

WITHDRAWN: Prognostic significance of circulating lymphocyte subsets in patients with nasopharyngeal carcinoma

WITHDRAWN: Prognostic significance of circulating lymphocyte subsets in patients with nasopharyngeal carcinoma

Aberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy

Changes of proportions of circulating lymphocyte subsets in cancer patients after chemotherapy

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