Impact of Recipient Obesity on Living Donor Kidney Transplant Outcomes: A Single-Center Experience

Mehta, Rajil; Shah, Gaurang; Leggat, John; Hubbell, Charlene; Roman, Ashley M.; Kittur, Dilip S.; Narsipur, Sriram S.

doi:10.1016/j.transproceed.2007.02.084

Cited by 22 publications

(16 citation statements)

References 12 publications

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“…Of these variables, only BMI, history of significant weight loss, transfusion during the operative hospitalization, and desensitization therapy proved to be independent risk factors in the multivariate analysis. Obesity as defined by a BMI >30 kg/m 2 has long been established as a risk factor for developing wound complications [10][11][12][13][14]. Our data corroborates the conclusions from those previous studies.…”

Section: Discussionsupporting

confidence: 92%

Renal Transplant Wound Complications in the Modern Era of Obesity

Kuo

Wong

Perez

et al. 2012

Journal of Surgical Research

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Section: Discussionsupporting

confidence: 92%

Renal Transplant Wound Complications in the Modern Era of Obesity

Kuo

Wong

Perez

et al. 2012

Journal of Surgical Research

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“…The total rejection episodes and graft survival after rejection were comparable in both the obese and nonobese groups in our study. Acute rejection episodes at our center were comparable to the results of Mehta et al [28] (19 vs. 8% in obese vs. nonobese patients).…”

Section: Discussionsupporting

confidence: 89%

“…Our 1-year death-censored graft survival in obese patients (90%) was comparable to the results of Mehta et al [28] (94%), though their sample involved living donors. Rettkowski et al [29 ]have demonstrated an association between poor graft survival and increased risk for allograft rejection in patients with a BMI <23.…”

Section: Discussionsupporting

confidence: 87%

The Effects of Body Mass Index on Graft Survival in Adult Recipients Transplanted with Single Pediatric Kidneys

et al. 2008

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Background: There is insufficient data on the impact of recipient body mass index (BMI) on the long-term graft survival of adult patients transplanted with single pediatric kidneys. Methods: We performed a retrospective analysis of adult patients transplanted with single pediatric kidneys at our center. The recipients were classified into 2 groups: group 1 (BMI ≥30) and group 2 (BMI <30). Donor/recipient demographics, postoperative outcomes and survival rates were compared between the 2 groups. Results: There was no significant difference in donor/recipient demographics between the 2 groups. In group 1, the death-censored graft survival (DCGS) at 1, 3 and 5 years was 90% at all 3 time points, and in group 2 it was 86, 68 and 60%, respectively (p = 0.05). The mean glomerular filtration rate (with standard deviation in parentheses) at 1, 3 and 5 years was, respectively, 55 (15), 59 (19) and 55 (28) ml/min for group 1, compared to 65 (28), 69 (23) and 67 (20) ml/min in group 2 (p = NS). Multivariate analysis revealed a hazard ratio of 5.12 (95% confidence interval 1.06–24.7; p = 0.04) for graft loss in nonobese patients when compared to obese patients. Obese patients had an increased risk for acute rejections within the first month of transplant (p = 0.02). Conclusion: Patients with a BMI ≥30 transplanted with single pediatric kidneys have better DCGS rates when compared to nonobese patients.

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“…The prevailing information on obesity and its impact on graft and patient survival after kidney transplantation has been derived mostly in non‐African American patients (1–4, 7–14). Furthermore, the number of obese patients as well as the duration of follow‐up in single‐center studies has been limited.…”

mentioning

confidence: 99%

Long‐term kidney transplant outcome in obese patients in a predominantly African American population

Karabıçak

Aytug

Lewis

et al. 2011

Clinical Transplantation

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The impact of obesity on long-term kidney transplant outcome has largely been studied in non-African American patients. This study seeks to determine differences in outcome between obese and non-obese patients after kidney transplantation, in a predominantly African American population. We reviewed 642 adult renal transplant recipients who received their transplants at SUNY Downstate Medical Center between 1998 and 2007. Sixty-six percent of the patients studied were African American. The patients were divided into five groups according to their BMI status: underweight <20, normal 20-24.9, overweight 25-29.9, obese 30-34.9, and morbidly obese ≥35. There were no differences in race, gender, cytomegalovirus infection, type of transplant, panel-reactive antibody, retransplant status, flow cytometry cross-match results, mycophenolate mofetil therapy, and total HLA mismatch status. The mean discharge serum creatinine in the morbidly obese group was significantly higher than in other groups (p < 0.001). The difference in creatinine level disappeared at six wk and six months (p > 0.5), respectively. Acute rejection rates, delayed graft function, graft survival, and patient survival were not different between the groups. The findings from this large single-center study suggest that obese and morbidly obese patients had similar outcomes compared to other weight groups. Obese and morbidly obese African American patients should not be excluded from kidney transplantation on the basis of weight alone.

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Impact of Recipient Obesity on Living Donor Kidney Transplant Outcomes: A Single-Center Experience

Cited by 22 publications

References 12 publications

Renal Transplant Wound Complications in the Modern Era of Obesity

Renal Transplant Wound Complications in the Modern Era of Obesity

The Effects of Body Mass Index on Graft Survival in Adult Recipients Transplanted with Single Pediatric Kidneys

Long‐term kidney transplant outcome in obese patients in a predominantly African American population

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