Impact of recurrent acute pancreatitis on the natural history and progression to chronic pancreatitis

Shah, Ishani; Bocchino, Rachel L.; Ahmed, Awais; Freedman, Steven D.; Kothari, Darshan; Sheth, Sunil G.

doi:10.1016/j.pan.2022.09.237

Cited by 7 publications

(18 citation statements)

References 39 publications

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“…This proportion differs from previous studies that reported proportions of 40% 11 or 60%. 12 Additionally, in our study, CP without AP was diagnosed at a younger age compared to CP with AP. This nding contrasts with previous result that showed a younger age in CP with AP.…”

Section: Discussionmentioning

confidence: 47%

“…CP with AP has been reported to exhibit a higher symptom burden and a greater number of ares than CP without AP. 12 These patients are often active smokers and have alcohol-related etiology for their CP. The increased risk of PC in these individuals could be attributed to the "injuryin ammation-cancer" pathway.…”

Section: Discussionmentioning

confidence: 99%

“…11 Pancreatitis manifests as different stages within the same disease spectrum, including single episode of acute pancreatitis (SAP), recurrent AP (RAP), early CP, established CP and end stage CP. 12 Although RAP and CP differ in terms of pancreatic morphology and/or histology, a subset of RAP patient may show histological evidence of CP. However, only a quarter to half of CP patients have a prior history of AP.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and risk of pancreatic cancer in patients with acute or chronic pancreatitis: a population-based cohort study

Park

Kim

Han

et al. 2023

Preprint

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We aimed to evaluate the incidence and risk of PC in pancreatitis. We identified patients with acute pancreatitis (AP) (n = 225,811, 50.0%) and chronic pancreatitis (CP) (n = 225,685, 50.0%) from Korean population-based data and matched them with age- and sex-matched controls (n = 4,514,960). We analyzed the incidence and adjusted hazard ratios (aHRs) of PC among patients followed for more than 2 years or 5 years, and assessed risk changes over time in single episode of AP (SAP), recurrent AP (RAP), CP with AP, and CP without AP groups. We also performed subgroup analysis for both sexes. The incidences (per 104 person-years) and risks (aHR) of PC were higher in the RAP (12.69, 5.00) or CP with AP (12.12, 5.74) groups compared to the SAP (2.31, 1.32) or CP without AP (2.28, 1.57) groups. The risks of PC decreased over time, however, the risk of PC remained elevated in the RAP and CP with AP groups for more than 8 years. Females with RAP, SAP, and CP with AP had higher risks of PC than males. The risk of PC is higher and persists for longer duration in patients with RAP and CP with AP compared to those with SAP or CP without AP.

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Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence and risk of pancreatic cancer in patients with acute or chronic pancreatitis: a population-based cohort study

Park

Kim

Han

et al. 2023

Preprint

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“…1 H NMR (400 MHz, CD 3 OD): δ: 1.62 (bs, 10H, CH 2 ); 1.93−1.96 (m, 15H, CH 2 and CH); 5.22 (s, 2H, CH 2 ); 6.31 (d, 1H, aryl, J = 4.6 Hz); 6.89 (t, 3H, aryl, J = 10.4 Hz); 7.02−7.05 (m, 2H, aryl); 7.09 (d, 1H, aryl, J = 8.8 Hz); 7.13 (d, 1H, aryl, J = 3.1 Hz); 7.41 (s, 1H, aryl). 13 Synthesis of (4-Fluorophenyl)(5-nitro-1H-indol-1-yl)methanone (34). To a solution of 0.1 mmol of 5-nitroindole in dichloromethane/ dimethylformamide (1/1, v/v) 4-fluorobenzoyl chloride (0.6 mmol) and triethylamine (0.6 mmol) were added.…”

Section: Synthesis Of (3r5r7r)-n-(1-(4-fluorobenzyl)indolin-5-yl)adam...mentioning

confidence: 99%

“…J = 8.3 Hz); 7.29 (d, 1H, aryl, J = 4.7 Hz); 7.55 (s, 1H, aryl) 13. C NMR (100 MHz, CDCl 3 ) δ 23.9, 28.3, 33.8, 34.0, 37.0, 40.2, 50.1, 52.9, 101.7, 110.6, 117.7, 120.0, 126.8, 129.3, 129.57, 129.69, 134.47, 134.67, 148.6, 157.7.…”

mentioning

confidence: 99%

Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis

et al. 2023

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Acute pancreatitis (AP) is a potentially life-threatening illness characterized by an exacerbated inflammatory response with limited options for pharmacological treatment. Here, we describe the rational development of a library of soluble epoxide hydrolase (sEH) inhibitors for the treatment of AP. Synthesized compounds were screened in vitro for their sEH inhibitory potency and selectivity, and the results were rationalized by means of molecular modeling studies. The most potent compounds were studied in vitro for their pharmacokinetic profile, where compound 28 emerged as a promising lead. In fact, compound 28 demonstrated a remarkable in vivo efficacy in reducing the inflammatory damage in cerulein-induced AP in mice. Targeted metabololipidomic analysis further substantiated sEH inhibition as a molecular mechanism of the compound underlying anti-AP activity in vivo. Finally, pharmacokinetic assessment demonstrated a suitable profile of 28 in vivo. Collectively, compound 28 displays strong effectiveness as sEH inhibitor with potential for pharmacological AP treatment.

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Impact of Ethno-racial Factors on Clinical Outcomes and Health Care Utilization in Chronic Pancreatitis

Chhoda,

McHenry,

Liyen Cartelle

et al. 2024

J. Racial and Ethnic Health Disparities

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Impact of recurrent acute pancreatitis on the natural history and progression to chronic pancreatitis

Cited by 7 publications

References 39 publications

Incidence and risk of pancreatic cancer in patients with acute or chronic pancreatitis: a population-based cohort study

Incidence and risk of pancreatic cancer in patients with acute or chronic pancreatitis: a population-based cohort study

Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis

Impact of Ethno-racial Factors on Clinical Outcomes and Health Care Utilization in Chronic Pancreatitis

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