Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases: protocol for a prospective cohort study of prognostic factors and personalised medicine

Christensen, Robin; Heitmann, Berit Lilienthal; Andersen, Kjeld; Nielsen, Ole Haagen; Sørensen, Grith Lykke; Jawhara, Mohamad; Bygum, Anette; Hvid, Lars G.; Grauslund, Jakob; Wied, Jimmi; Glerup, Henning; Fredberg, Ulrich; Villadsen, Jan Alexander; Kjær, Søren G.; Fallingborg, Jan; Moghadd, Seyed A G R; Knudsen, Torben; Brodersen, Jacob Broder; Frøjk, Jesper; Dahlerup, Jens Frederik; Bojesen, Anders Bo; Sørensen, Grith Lykke; Thiel, Steffen; Færgeman, Nils J.; Brandslund, Ivan; Bennike, Tue Bjerg; Stensballe, Allan; Schmidt, Erik Berg; Franke, André; Ellinghaus, David; Rosenstiel, Philip; Raes, Jeroen; Boye, Mette; Werner, Lars; Nielsen, Charlotte Lindgaard; Munk, Heidi Lausten; Nexøe, Anders Bathum; Ellingsen, Torkell; Holmskov, Uffe; Kjeldsen, Jens; Andersen, Vibeke

doi:10.1136/bmjopen-2017-018166

Cited by 23 publications

(37 citation statements)

References 122 publications

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“…The detailed aetiology of the IBDs remains unknown, but experimental and observational studies such as meta-analyses and cohort-and case-control studies suggest that CD and UC have both genetic and environmental predisposing factors (16)(17)(18)(19)(20). Use of nonsteroidal anti-in ammatory drugs (NSAIDs)(21), use of hormone replacement therapy (HRT) (22), obesity (23,24) and dietary factors such as red meat (25) and alcohol (26,27) have been suggested as risk factors for intestinal in ammation and onset of IBD, whilst it is suggested that intake of dietary bre (16,28) and fermented dairy products (29,30) may play a preventative role. Interestingly smoking, has been associated with a higher risk of CD, whilst is seen as being protective for UC (31,32).…”

Section: Chronic In Ammatory Bowel Diseasesmentioning

confidence: 99%

Associations between participation in, intensity of, and time spent on leisure time physical activity and risk of inflammatory bowel disease among older adults (PA-IBD): A prospective cohort study

Rasmussen

Bech

Rubin

et al. 2020

Preprint

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Abstract Background: Inflammatory bowel diseases (IBDs) are diseases of the immune system that share some genetic and lifestyle-related predisposing factors. Increasing incidences have been reported in all age groups. Based on experimental studies suggesting a role of physical activity on intestinal inflammation, this study aimed to investigate the association between leisure time physical activity and the risk of IBD in older adults. Methods: The study is a prospective cohort study using Danish registry data and questionnaire data from the Danish “Diet, Cancer and Health” cohort. The outcome IBD was defined as having at least two main diagnoses of Crohn’s disease or ulcerative colitis registered in the National Patient Registry from the period between December 1993 and May 1997 with an average follow-up of 25 years. Cox proportional hazard models were used to estimate hazard-ratios for IBD onset associated with being physically active and with levels of the metabolic equivalent of task (MET) hours/week of physical activity and hours/week spent on six types of physical activity. All analyses were adjusted for potential confounders. Furthermore, the analyses were stratified according to age-group, occupational physical activity, smoking, BMI and work status to test for effect modification. Results: In total, 54 645 men and women aged between 50-64 years were included, and of which there were 529 cases. When comparing physically active with inactive participants measured by MET hours/week there was no statistically significant difference in risk of IBD (0.89 [0.13; 6.27]), regardless of how participation was measured. Results did not indicate any dose-response effect when comparing quartile groups of MET hours/week (HR=0.97 [0.76 ; 1.22], HR=0.82 [0.64 ; 1.05] and HR=0.83 [0.65 ; 1.07] or whether five of the six types of activities were compared with the lowest quartile as reference. For do-it-yourself-work, the third quartile of hours/week was associated with a higher risk of IBD compared to the second quartile of hours/week (HR=1.44 [1.10 ; 1.90]. No effect modification was found. Conclusions: There was no association between physical activity and risk of IBD when comparing physically active with inactive participants. Neither did the results indicate any dose-response effect when comparing quartile groups of MET hours/week with the lowest quartile as reference. Do-it-yourself work, however, appeared to be associated with a higher risk of IBD when comparing the third quartile with the second quartile of hours/week. The study has clinical relevance by its contribution to the explanatory field of the causes of IBD. However, the study has some limitations, and further research is needed to clarify associations between physical activity and risk of IBD.

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Section: Chronic In Ammatory Bowel Diseasesmentioning

confidence: 99%

Associations between participation in, intensity of, and time spent on leisure time physical activity and risk of inflammatory bowel disease among older adults (PA-IBD): A prospective cohort study

Rasmussen

Bech

Rubin

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…The detailed aetiology of the IBDs remains unknown, but experimental and observational studies such as meta-analyses and cohort-and case-control studies suggest that CD and UC have both genetic and environmental predisposing factors (16)(17)(18)(19)(20). Use of nonsteroidal anti-inflammatory drugs (NSAIDs) (21), use of hormone replacement therapy (HRT) (22), obesity (23,24) and dietary factors such as red meat (25) and alcohol (26,27) have been suggested as risk factors for intestinal inflammation and IBD onset, while a preventative role of intake of dietary fibre (16,28) and fermented dairy products (29,30) has been suggested. Smoking, however, has been associated with a higher risk of CD, while being protective for UC (31,32).…”

Section: Chronic Inflammatory Bowel Diseasesmentioning

confidence: 99%

Associations between participation in, intensity of, and time spent on leisure time physical activity and risk of inflammatory bowel disease among older adults (PA-IBD): A prospective cohort study

Rasmussen

Bech

Rubin

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background Inflammatory bowel diseases (IBDs) are diseases of the immune system that share some genetic and lifestyle-related predisposing factors. Increasing incidences have been reported in all age groups. Based on experimental studies suggesting a role of physical activity on intestinal inflammation, this study aimed to investigate the association between leisure time physical activity and the risk of IBD in older adults. Methods The study is a prospective cohort study using Danish registry data and questionnaire data from the Danish “Diet, Cancer and Health” cohort. The outcome IBD was defined as having at least two diagnoses of Crohn’s disease or ulcerative colitis registered in the National Patient Registry during follow-up between December 1993 and May 1997 until December 2018. Cox proportional hazard models were used to estimate hazard ratios for IBD onset associated with being physically active and with levels of the metabolic equivalent of task (MET) hours/week of physical activity and hours/week spent on six types of physical activity. Results In total, 54 645 men and women aged 50-64 years were included, and thereof 529 cases. When comparing physically active with inactive participants measured by MET hours/week there was no statistically significant difference in risk of IBD (0.89 [0.13; 6.27]), neither when measured as participation in six types of activities. Results did not indicate any dose-response effect when comparing quartile groups of MET hours/week or of five of the six types of activities. For do-it-yourself-work, the third quartile of hours/week was associated with a higher risk of IBD compared to the second quartile (HR=1.44 [1.10 ; 1.90]. No effect modification was found. Conclusions There was no association between physical activity and risk of IBD when comparing physically active with inactive participants. Neither did the results indicate any dose-response effect when comparing quartile groups of MET hours/week. Do-it-yourself work, however, seemed to be associated with a higher risk of IBD when comparing the third quartile with the second quartile. The study has clinical relevance by its contribution to the explanatory field of the causes of IBD. However, further research is needed to clarify associations between physical activity and risk of IBD.

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“…We cannot exclude the possibilities of harmful effects of food additives on IBD, although the relevant human data are deficient. Several prospective cohorts have been conducted to figure out the underlying relationship.…”

Section: Diet In the Pathogenesis Of Ibdmentioning

confidence: 99%

“…29 We cannot exclude the possibilities of harmful effects of food additives on IBD, although the relevant human data are deficient. Several prospective cohorts 22,30 have been conducted to figure out the underlying relationship. 31 But such a protective effect was only found in those having a higher intake of fibers derived from fruits rather than that from whole grain, legumes and cereals.…”

Section: Food Additivesmentioning

confidence: 99%

The role of dietary factors in inflammatory bowel diseases: New perspectives

Zhou

Yan

2018

J of Digest Diseases

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The current review aimed to elucidate the role of diet in every stage of inflammatory bowel diseases, from aspects of prevention, treatment and rehabilitation. Western diet, characterized by overconsumption of refined sugar and saturated fat and low consumption of dietary fiber, may partly be blamed for its pathogenesis. Some immune‐modulated nutrients (fibers, monounsaturated fatty acids, n‐3 polyunsaturated fatty acids and vitamin D) exert their potential beneficial effects on gut microbiota and immune function, resulting in clinical remission and/or preventing relapse. However, data is limited to conclude optimal micronutrient levels and therapeutic implications. Further, diet itself is complex; therefore, it is reasonable to evaluate diet as a whole rather than a single type of food. Some specific dietary patterns are generated for the management of inflammatory bowel diseases with controversial results. Only exclusive enteral nutrition has been widely recommended for pediatric patients with non‐stricturing active Crohn's disease. Self‐monitoring, avoidance of certain types of foods, limited intake of alcohol and smoking, supplementation of minerals and vitamins if deficiency is confirmed, and adherence to the diet enriched in vegetables and fruits and low in animal food and un‐digested fiber during flares are the most common dietary recommendation. Further clinical trials with a high evidence rank are warranted.

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Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases: protocol for a prospective cohort study of prognostic factors and personalised medicine

Cited by 23 publications

References 122 publications

Associations between participation in, intensity of, and time spent on leisure time physical activity and risk of inflammatory bowel disease among older adults (PA-IBD): A prospective cohort study

Associations between participation in, intensity of, and time spent on leisure time physical activity and risk of inflammatory bowel disease among older adults (PA-IBD): A prospective cohort study

Associations between participation in, intensity of, and time spent on leisure time physical activity and risk of inflammatory bowel disease among older adults (PA-IBD): A prospective cohort study

The role of dietary factors in inflammatory bowel diseases: New perspectives

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