In article the authors substantiate that fuel consumption of combine harvester is usually influenced by design features of combine harvester: productivity, engine capacity and fuel efficiency of engine, the size of silo and grain unloading speed, the transport speed of combine, and other design features. The authors found out that specific fuel consumption of combine harvester tends to decrease with increasing of crop yield. When the normative yield, which provides passport throughput of combine, is achieved, further reduction of specific fuel consumption becomes minimal. This reduction is greater for straw – 1:1.0. Therefore, when the ratio of grain to non-grain part of mass is 1:1.5 and yield is increased to 2.5 t/ha, we observe sharp decrease in specific fuel consumption. The straw index also significantly influences the formation of specific fuel consumption of combine harvester, with yield of 4.5 t/ha and ratio of grain to non-grain part of 1:1.0, the specific fuel consumption is 2.83 l/t, and at the same yield and straw rate and ratio of grain to non-grain part of 1:2 the specific fuel consumption is 4.15 l/t (increase of 47%).