Impact of Resistance on Therapeutic Design: A Moran Model of Cancer Growth
Mason S. Lacy,
Adrianne L. Jenner
Abstract:Resistance of cancers to treatments, such as chemotherapy, largely arise due to cell mutations. These mutations allow cells to resist apoptosis and inevitably lead to recurrence and often progression to more aggressive cancer forms. Sustained-low dose therapies are being considered as an alternative over maximum tolerated dose treatments, whereby a smaller drug dosage is given over a longer period of time. However, understanding the impact that the presence of treatment-resistant clones may have on these new t… Show more
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