The gas puff imaging (GPI) diagnostic is used for the investigation of the poloidal flow and turbulent fluctuations in the plasma edge and Scrape-Off Layer (SOL) on the HL-2A tokamak. The impacts of Resonant Magnetic Perturbations (RMP) on the edge poloidal velocity (V_θ) are investigated and compared during operation of stair-like rising RMP coil current (I_RMP). The application of RMP is observed to modify the poloidal velocity significantly. When I_RMP exceeds 4 kA, the turbulence poloidal velocity in the edge changes direction from electron to ion diamagnetic drift. This phenomenon is explained by the electron loss along the perturbed B_r with RMP, with the experimental evidence provided that the edge electric potential increases significantly. A strong impact of the RMP on the properties of plasma density fluctuations in the SOL is also observed. With RMP, both skewness and kurtosis are smaller in the SOL and large-scale turbulence structures (small k_rand k_θ) are suppressed in both edge and SOL. These results can improve the understanding of the interaction between RMP and the edge turbulence and particularly the edge poloidal flow.