Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study

Loubet, Paul; Voiriot, Guillaume; Houhou‐Fidouh, Nadhira; Neuville, Mathilde; Bouadma, Lila; Lescure, François-Xavier; Descamps, Diane; Timsit, Jean‐François; Yazdanpanah, Yazdan; Visseaux, Benoît

doi:10.1016/j.jcv.2017.04.001

Cited by 59 publications

(71 citation statements)

References 34 publications

(37 reference statements)

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“…All these elements provide additional evidence that these infections could be classified as healthcare-associated infections. Similarly, to what is observed for influenza viruses, parainfluenza virus type 3 and respiratory syncytial virus, our data show that HCoV−OC43 is involved in healthcare-associated infections [33][34][35].…”

Section: Discussionsupporting

confidence: 87%

Use of whole-genome sequencing in the molecular investigation of care-associated HCoV-OC43 infections in a hematopoietic stem cell transplant unit

Beury

Fléchon

Maurier

et al. 2020

Journal of Clinical Virology

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A B S T R A C TBackground: While respiratory viral infections are recognized as a frequent cause of illness in hematopoietic stem cell transplantation (HSCT) recipients, HCoV−OC43 infections have rarely been investigated as healthcareassociated infections in this population. Objectives: In this report, HCoV−OC43 isolates collected from HSCT patients were retrospectively characterized to identify potential clusters of infection that may stand for a hospital transmission. Study design: Whole-genome and S gene sequences were obtained from nasal swabs using next-generation sequencing and phylogenetic trees were constructed. Similar identity matrix and determination of the most common ancestor were used to compare clusters of patient's sequences. Amino acids substitutions were analysed. Results: Genotypes B, E, F and G were identified. Two clusters of patients were defined from chronological data and phylogenetic trees. Analyses of amino acids substitutions of the S protein sequences identified substitutions specific for genotype F strains circulating among European people. Conclusions: HCoV−OC43 may be implicated in healthcare-associated infections.

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Section: Discussionsupporting

confidence: 87%

Use of whole-genome sequencing in the molecular investigation of care-associated HCoV-OC43 infections in a hematopoietic stem cell transplant unit

Beury

Fléchon

Maurier

et al. 2020

Journal of Clinical Virology

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“…Viral infections presenting concurrently with bacterial CAP are now known to occur with a frequency of 30-50% in both adult and pediatric populations [64][65][66][67]. Interestingly, it would be more intuitive to assume that CAP would be the most severe manifestation of these co-infections, but more recently there have been several studies demonstrating these viral-bacterial infections also affect 10-20% of patients with hospital-acquired pneumonia (HAP) [44,[68][69][70]. In a large cohort study with over 2,000 patients hospitalized with severe H1N1pdm09 influenza, the following risk factors were identified for developing HAP: need for mechanical ventilation, sepsis, ICU admission on the first day, lymphocytopenia, older age, and anemia.…”

Section: Role Of Viral-bacterial Co-infections and Their Effect On Oumentioning

confidence: 99%

Influenza virus-related critical illness: pathophysiology and epidemiology

2019

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Influenza virus affects the respiratory tract by direct viral infection or by damage from the immune system response. In humans, the respiratory epithelium is the only site where the hemagglutinin (HA) molecule is effectively cleaved, generating infectious virus particles. Virus transmission occurs through a susceptible individual’s contact with aerosols or respiratory fomites from an infected individual. The inability of the lung to perform its primary function of gas exchange can result from multiple mechanisms, including obstruction of the airways, loss of alveolar structure, loss of lung epithelial integrity from direct epithelial cell killing, and degradation of the critical extracellular matrix. Approximately 30–40% of hospitalized patients with laboratory-confirmed influenza are diagnosed with acute pneumonia. These patients who develop pneumonia are more likely to be < 5 years old, > 65 years old, Caucasian, and nursing home residents; have chronic lung or heart disease and history of smoking, and are immunocompromised. Influenza can primarily cause severe pneumonia, but it can also present in conjunction with or be followed by a secondary bacterial infection, most commonly by Staphylococcus aureus and Streptococcus pneumoniae . Influenza is associated with a high predisposition to bacterial sepsis and ARDS. Viral infections presenting concurrently with bacterial pneumonia are now known to occur with a frequency of 30–50% in both adult and pediatric populations. The H3N2 subtype has been associated with unprecedented high levels of intensive care unit (ICU) admission. Influenza A is the predominant viral etiology of acute respiratory distress syndrome (ARDS) in adults. Risk factors independently associated with ARDS are age between 36 and 55 years old, pregnancy, and obesity, while protective factors are female sex, influenza vaccination, and infections with Influenza A (H3N2) or Influenza B viruses. In the ICU, particularly during the winter season, influenza should be suspected not only in patients with typical symptoms and epidemiology, but also in patients with severe pneumonia, ARDS, sepsis with or without bacterial co-infection, as well as in patients with encephalitis, myocarditis, and rhabdomyolysis.

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“…Enfin, un avantage non négligeable des PCR multiplexes est l'amélioration des flux patients. Parce que les PCR multiplexes diminuent le recours à d'autres examens de biologie ou de radiologie [7], parce que les PCR facilitent un diagnostic plus précoce [7], parce qu'elles limitent l'utilisation de certains médicaments [8], parce qu'elles pourraient réduire les infections nosocomiales [9], les PCR multiplexes devraient diminuer la durée de passage aux urgences et la durée d'hospitalisation. Dans une étude observationnelle réalisée aux urgences du CHU Grenoble Alpes, nous avons montré que l'utilisation d'une PCR rapide grippe VRS diminuent de 20 % la durée de passage aux urgences lorsque le résultat est positif.…”

Section: Pourunclassified

Controverse : pour ou contre la PCR multiplexe dans les infections respiratoires

2018

La Revue de Médecine Interne

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Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study

Cited by 59 publications

References 34 publications

Use of whole-genome sequencing in the molecular investigation of care-associated HCoV-OC43 infections in a hematopoietic stem cell transplant unit

Use of whole-genome sequencing in the molecular investigation of care-associated HCoV-OC43 infections in a hematopoietic stem cell transplant unit

Influenza virus-related critical illness: pathophysiology and epidemiology

Controverse : pour ou contre la PCR multiplexe dans les infections respiratoires

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