Impact of Reticular Pseudodrusen on Macular Function

Abstract

Eyes with reticular pseudodrusen present a greater extent of reduced sensitivity than eyes with typical drusen.

Photoreceptor Damage and Reduction of Retinal Sensitivity Surrounding Geographic Atrophy in Age-Related Macular Degeneration

“…29,30 Several reports have shown that retinal sensitivity is reduced in eyes with pseudodrusen. [31][32][33][34] Consistent with these reports, the mean retinal sensitivity of the area without photoreceptor damage and RPE loss was lower in eyes with pseudodrusen compared with eyes without them. All these results indicate that pseudodrusen themselves may cause retinal sensitivity reduction.…”

Prevalence of Subtypes of Reticular Pseudodrusen in Newly Diagnosed Exudative Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Korean Patients

“…34 Impaired nutrient exchange between photoreceptors and choriocapillaris due to blocked access by pseudodrusen material accumulation has been suggested as one of the possible mechanisms underlying this relationship. 33 We postulate that this blocking effect is greater in ribbon pseudodrusen than in dot pseudodrusen because ribbon pseudodrusen is usually larger and has a more densely packed appearance than dot pseudodrusen. In this study, eyes with ribbon pseudodrusen exhibited relatively thin choroids than those with dot pseudodrusen only.…”

Exploring choriocapillaris under reticular pseudodrusen using OCT-Angiography

“…Furthermore, RPD are known to affect photoreceptor function, in particular function of rods [8][9][10][11][12][13][14][15]. Together with a higher RPD prevalence in predominantly rod-rich macular regions and a spatial correlation of RPD and damaged rod photoreceptors, it was hypothesized that a pathophysiologic relation may exist between RPD and rods [16].…”