Impact of Reticulated Platelets on the Antiplatelet Effect of the Intravenous P2Y12-Receptor Inhibitor Cangrelor

Stratz, Christian; Nührenberg, Thomas; Valina, Christian; Löffelhardt, Nikolaus; Mashayekhi, Kambis; Ferenc, Mirosław; Trenk, Dietmar; Neumann, Franz‐Josef; Hochholzer, Willibald

doi:10.1160/th17-07-0466

Cited by 13 publications

(20 citation statements)

References 38 publications

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“…In addition, reticulated platelets might be less sensitive to antiplatelet therapy, which might contribute to the increased risk for ischemic events in patients with diabetes [78]. However, the sensitivity of reticulated platelets to platelet inhibitors might depend on the compound and the contribution of this young platelet fraction to resistance to antiplatelet therapy is currently still incompletely clarified [79][80][81].…”

Section: Platelet Hyperreactivity As Risk Factor For Atherosclerotic mentioning

confidence: 99%

The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events

et al. 2021

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Atherosclerosis is an underlying cause of a broad array of cardiovascular diseases characterized by plaques, arterial wall thickening initiated by hyperlipidemia, pro-inflammatory signals, endothelial dysfunction and the influx of inflammatory cells. By still incompletely characterized mechanisms, these plaques can destabilize or erode, leading to thrombosis and blood vessel occlusion and becomes clinically manifest as angina pectoris, myocardial infarction (MI) or stroke. Among the several blood cell types that are involved in the development of atherosclerosis, the role of platelets during the thrombotic occlusion of ruptured or eroded plaques is well established and clinically exploited as evident by the extensive use of platelet inhibitors. However, there is increasing evidence that platelets are also involved in the earlier stages of atheroma development by exhibiting pro-inflammatory activities. The scope of this review is to describe the role of platelets in the initiation and propagation stages of atherosclerosis and beyond; in atherothrombotic complications.

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Section: Platelet Hyperreactivity As Risk Factor For Atherosclerotic mentioning

confidence: 99%

The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events

et al. 2021

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“…Much effort has been directed into understanding mechanisms and targets for antiplatelet drugs, and prognostic implications. [1][2][3] The good news is that nowadays we already have established medications that interfere with platelet adhesion and subsequent aggregation, and that we can measure platelet function ex vivo. 4 The closed balance between aggregation on one hand and bleeding on the other is the focus of the theme issue Platelets that has been released today.…”

mentioning

confidence: 99%

Platelets: The Balance between Aggregation and Bleeding

Verheugt

2019

Thromb Haemost

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“…88 It has been shown that immature platelets differently influence platelet aggregation of P2Y 12 receptor inhibitors. [89][90][91] Taken together, the combination of a prothrombotic milieu and reduced response to some antiplatelet drugs may increase the risk of developing MACE.…”

Section: Biological Mechanismsmentioning

confidence: 99%

Immature Platelets and Risk of Cardiovascular Events among Patients with Ischemic Heart Disease: A Systematic Review

et al. 2020

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Background Immature platelets are larger and may be more thrombogenic than mature platelets. This systematic review included studies on the association between mean platelet volume (MPV), immature platelet count (IPC), and immature platelet fraction (IPF) and the risk of major cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS) or stable coronary artery disease (CAD). Methods The literature search included studies in PubMed, Embase, Web of Science, and Cochrane Library. The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Effect estimates that included multivariate adjusted odds ratios, relative risks, or hazard ratios were extracted. Results Forty-two studies were identified. High MPV was positively associated with MACE in 20 of 26 studies of patients with ACS, four of five studies in patients with stable CAD, and in all six studies comprising a combined population with ACS and stable CAD. Using continuous models of MPV in patients with ACS, effect estimates varied from 0.90 (95% confidence interval [CI]: 0.95–1.03) to 1.66 (95% CI: 1.32–2.09). The strength of these associations was broadly similar among patients with stable CAD and in combined populations. Five studies investigated IPC or IPF as exposures and all reported positive associations with MACE among patients with ACS, stable CAD, or in combined populations. Conclusion This review demonstrated clear evidence for positive associations between measures of immature platelets and subsequent risk of MACE in acute and stable ischemic heart disease patients.

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Impact of Reticulated Platelets on the Antiplatelet Effect of the Intravenous P2Y12-Receptor Inhibitor Cangrelor

Abstract: Platelet inhibition is not influenced by levels of reticulated platelets during infusion of cangrelor independent of oral P2Y-receptor inhibitor transitioning strategy. These findings underline the potency of cangrelor as immediate and reversibly acting P2Y-receptor inhibitor.

Cited by 13 publications

References 38 publications

The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events

The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events

Platelets: The Balance between Aggregation and Bleeding

Immature Platelets and Risk of Cardiovascular Events among Patients with Ischemic Heart Disease: A Systematic Review

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