Impact of Rhabdoid Differentiation on Prognosis for Patients with Grade 4 Renal Cell Carcinoma

Zhang, Ben Y.; Cheville, John C.; Thompson, R. Houston; Lohse, Christine M.; Boorjian, Stephen A.; Leibovich, Bradley C.; Costello, Brian A.

doi:10.1016/j.eururo.2015.01.002

Cited by 29 publications

(30 citation statements)

References 9 publications

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“…Gökden et al [3] initially described rhabdoid features in RCCs. The incidence of rhabdoid features was reported in approximately 1.4-7.4% of all RCCs [3,4,5,6,7,8,9]. We reported previously that the biological behavior of RCCs with rhabdoid features is highly aggressive and presents a very poor prognosis [5], which has been confirmed by other investigators [7,8,9,10].…”

Section: Introductionsupporting

confidence: 70%

“…The incidence of rhabdoid features was reported in approximately 1.4-7.4% of all RCCs [3,4,5,6,7,8,9]. We reported previously that the biological behavior of RCCs with rhabdoid features is highly aggressive and presents a very poor prognosis [5], which has been confirmed by other investigators [7,8,9,10]. Rhabdoid features were identified in several RCC histological subtypes, most commonly observed in clear cell RCC (ccRCC) [11], the most conventional histopathological subtype [12].…”

Section: Introductionmentioning

confidence: 99%

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Epithelial to Mesenchymal Transition in Clear Cell Renal Cell Carcinoma with Rhabdoid Features

et al. 2016

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Aims: The aims of this study were to investigate the association of renal cell carcinoma (RCC) displaying rhabdoid features and morphologically mesenchymal characteristics with epithelial to mesenchymal transition (EMT), and to clarify the expression of EMT markers. Methods: We investigated the expression of EMT markers (E-cadherin, vimentin, Snail, Slug, ZEB1, ZEB2 and Twist1) using immunohistochemistry, Western blotting and real-time polymerase chain reaction in 18 cases of clear cell RCC (ccRCC) with rhabdoid features and 74 ccRCC cases with Fuhrman grade 1-3 (G1 to G3). Results: In ccRCCs with rhabdoid features, low E-cadherin and high vimentin expression were found. In G1 to G3 ccRCCs, low E-cadherin expression and high expression of vimentin, ZEB1 and ZEB2 were found. There was no significant difference in the immunoexpression of E-cadherin and vimentin between the two ccRCC groups. Conclusions: The rhabdoid features may histologically and biologically be associated with EMT in ccRCC. There is a possibility that in G1 to G3 ccRCCs showing epithelial structures, other cell-cell adhesion mechanisms apart from E-cadherin adhesion may continue to work, and that ccRCC with rhabdoid features may be caused by an inactivation or loss of these mechanisms.

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Section: Introductionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Epithelial to Mesenchymal Transition in Clear Cell Renal Cell Carcinoma with Rhabdoid Features

et al. 2016

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“…The presence of sarcomatoid morphology has, however, been shown to have a more significant association with death from RCC than the presence of rhabdoid morphology [99]. …”

Section: Resultsmentioning

confidence: 99%

“…Sarcomatoid and rhabdoid cells may occur together and are both classified as WHO/ISUP grade 4 [ 1 ]. The presence of sarcomatoid morphology has, however, been shown to have a more significant association with death from RCC than the presence of rhabdoid morphology [ 99 ].…”

Section: Resultsmentioning

confidence: 99%

WHO/ISUP classification, grading and pathological staging of renal cell carcinoma: standards and controversies

2018

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“…In a series of 49 cases 78% were staging category pT3a or higher, and 53% of patients had died with a mean follow‐up of 25 months . In a more recent study, however, the 2‐year survival was 46% . Clear cell RCC with rhabdoid morphology shows variable genetic changes with loss of chromosomes 4, 9, 11p and 14, and gains of chromosome 7 being most frequently encountered .…”

Section: Who/isup Gradingmentioning

confidence: 98%

Grading of renal cell carcinoma

Delahunt¹,

et al. 2018

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Grading of renal cell carcinoma (RCC) has been recognised as a prognostic factor for almost 100 years. Numerous grading systems have been proposed, initially focusing upon a constellation of cytological features and more recently on nuclear morphology. It has been recommended that grading of RCC should be based upon nucleolar prominence/eosinophilia for grades 1–3, while grade 4 requires nuclear anaplasia (including tumour giant cells, sarcomatoid differentiation and/or rhabdoid morphology). The grading system was adopted formally by the International Society of Urological Pathology (ISUP) and subsequently by the World Health Organisation (WHO), being designated the WHO/ISUP grading classification in the fourth edition of the WHO classification tumours of the urinary system and male genital organs (2016). This grading system has been validated for both clear cell and papillary RCC. Validation studies for chromophobe RCC failed to demonstrate a correlation between grade and outcome for both the superseded Fuhrman grading system and the WHO/ISUP grading classification, and it has been recommended that these tumours not be graded. The WHO/ISUP system has been incorporated into the structured reports of the International Cancer Collaboration on Cancer Reporting for both clear cell and papillary RCC. It is also noted that other types of RCC may be graded, but it must be emphasised in the report that this is for descriptive and diagnostic purposes, and not outcome prediction. More recent studies have shown the incorporation of the presence of tumour necrosis into RCC grading to improve outcome prediction, and this has been validated in several studies.

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Impact of Rhabdoid Differentiation on Prognosis for Patients with Grade 4 Renal Cell Carcinoma

Cited by 29 publications

References 9 publications

Epithelial to Mesenchymal Transition in Clear Cell Renal Cell Carcinoma with Rhabdoid Features

Epithelial to Mesenchymal Transition in Clear Cell Renal Cell Carcinoma with Rhabdoid Features

WHO/ISUP classification, grading and pathological staging of renal cell carcinoma: standards and controversies

Grading of renal cell carcinoma

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