Impact of Risk Factors of Ischemic Heart Disease on the Development of Acute Coronary Syndrome, Platelet Ultrastructure, and Aspirin Resistance

Kyyak, Yulian H.; Barnett, Olga Yu.; Halkevych, Marta P.; Labinska, Olha Ye.; Kyyak, Hryhoriy Yu.; Kysil, Orysia Yu.

doi:10.36740/wlek201911107

Cited by 2 publications

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“…Hypertension with coronary heart disease is a common cardiovascular disease, with a high prevalence in the elderly [ 1 ]. The clinical manifestations include fatigue, palpitations, and angina pectoris.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Rosuvastatin, Amlodipine, and Aspirin in the Treatment of Hypertension with Coronary Heart Disease and Its Effect on Platelet Aggregation

Wang

et al. 2022

Disease Markers

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Objective. This study was to study the efficacy of rosuvastatin, amlodipine, and aspirin in the treatment of hypertension with coronary heart disease and its effect on platelet aggregation. Methods. The participants included 60 patients with hypertension and coronary heart disease who were treated at our hospital between January 2020 and May 2021 and were randomly assigned to receive either rosuvastatin, amlodipine, and Ziyin Huoxue Recipe (observation group) or rosuvastatin, amlodipine, Ziyin Huoxue Recipe, and aspirin (experimental group), with 30 patients in each. Outcome measures included clinical effectiveness, blood pressure indicators, blood lipid indices, plasma viscosity, platelet aggregation, cardiac function, and adverse responses. Results. The clinical efficacy in the experimental group was significantly higher than that in the observation group ( P < 0.05 ). The differences were found in blood pressure indices and blood lipid indices between the two groups before treatment ( P > 0.05 ). However, after treatment, the blood pressure indices in the experimental group were significantly lower than those in the observation group ( P < 0.05 ). After treatment, the blood lipid indices, plasma viscosity, and platelet aggregation in the experimental group were significantly lower than those in the observation group ( P < 0.05 ). The left ventricular ejection fraction (LVEF) of patients in the experimental group after treatment was significantly higher than that of patients in the observation group ( P < 0.05 ). There was no significant difference in the incidence of adverse reactions among patients in the two groups ( P > 0.05 ). Conclusion. The clinical efficacy of rosuvastatin, amlodipine, and aspirin markedly reduces the blood pressure indices, blood lipid indices, plasma viscosity, and platelet aggregation of patients with hypertension and coronary heart disease, improves LVEF, and has a good safety profile.

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Section: Introductionmentioning

confidence: 99%

The Efficacy of Rosuvastatin, Amlodipine, and Aspirin in the Treatment of Hypertension with Coronary Heart Disease and Its Effect on Platelet Aggregation

Wang

et al. 2022

Disease Markers

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“…The majority of platelets were found to be under an activated state, with pseudopedence, partial platelet aggregation, osmiophilism, vacuolation, and even calcification and apoptosis. Therefore, the researchers considered that AR may be caused by the degenerative changes and calcification of platelets (Kyyak et al, 2019).…”

Section: Other Mechanismsmentioning

confidence: 99%

Mechanism of Improving Aspirin Resistance: Blood-Activating Herbs Combined With Aspirin in Treating Atherosclerotic Cardiovascular Diseases

Zhao

Yang

2021

Front. Pharmacol.

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Atherosclerotic thrombotic disease continues to maintain a high morbidity and mortality rate worldwide at present. Aspirin, which is reckoned as the cornerstone of primary and secondary prevention of atherosclerotic cardiovascular diseases (ASCVDs), has been applied in clinics extensively. However, cardiovascular events continue to occur even though people utilize aspirin appropriately. Therefore, the concept of aspirin resistance (AR) was put forward by scholars, which is of great significance for the prediction of the clinical outcome of diseases. The pathogenesis of AR may be incorporated with low patient compliance, insufficient dose, genetic polymorphism, increased platelet transformation, inflammation, and the degenerative changes and calcification of platelets. The improvement of AR in the treatment of ASCVDs has gradually become a research hot spot in recent years. Traditional Chinese medicine (TCM) regards individuals as a whole and treats them from a holistic view, which has been found to have advantages in clinical studies on the treatment of AR. Many kinds of blood-activating TCM have the effect of improving AR. The potential mechanism for the improvement of AR by blood-activating herbs combined with aspirin was explored. The combination of blood-activating herbs and aspirin to improve AR is likely to turn into a hot topic of research in the future.

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Impact of Risk Factors of Ischemic Heart Disease on the Development of Acute Coronary Syndrome, Platelet Ultrastructure, and Aspirin Resistance

Cited by 2 publications

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The Efficacy of Rosuvastatin, Amlodipine, and Aspirin in the Treatment of Hypertension with Coronary Heart Disease and Its Effect on Platelet Aggregation

The Efficacy of Rosuvastatin, Amlodipine, and Aspirin in the Treatment of Hypertension with Coronary Heart Disease and Its Effect on Platelet Aggregation

Mechanism of Improving Aspirin Resistance: Blood-Activating Herbs Combined With Aspirin in Treating Atherosclerotic Cardiovascular Diseases

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