Impact of risk-reducing salpingo-oophorectomy in premenopausal women

Vermeulen, R F M; Beurden, Marc van; Korse, Catharina M.; Kenter, Gemma G.

doi:10.1080/13697137.2017.1285879

Cited by 46 publications

(30 citation statements)

References 70 publications

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“…PBSO renders an anticipated early menopause which has unfortunate physical and psychological consequences ([ 39 , 40 ]). Premenopausal women undergoing PBSO experience hot flashes and night sweats (40%), dyspareunia (17%), and decreased libido (22%) [ 41 ].…”

Section: Prophylactic Bilateral Salpingo-oophorectomy (Pbso)mentioning

confidence: 99%

Management of patients with BRCA mutation from the point of view of a breast surgeon

Riis

2021

Annals of Medicine &Amp; Surgery

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Germ-line mutation in BRCA (BReast CAncer gene) 1 or BRCA2 are found in 3–4% of all women with breast cancer. These patients have a significant increased risk of breast and ovarian cancer. They are often younger when diagnosed with the mutation, and the possible breast cancer they get is often aggressive with inferior outcome. There are risk reducing strategies, and the most powerful strategy is risk reducing surgery, both risk reducing bilateral mastectomy (RRM) and risk reducing bilateral salpino-oophorectomy (PBSO). This review is meant to address breast surgery in patients with germline BRCA mutation. The guidelines and techniques applied is under continuous change and it is important for the clinicians to be well informed to provide the patient with the information needed for them to make an informed decision on what risk strategy to choose.

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Section: Prophylactic Bilateral Salpingo-oophorectomy (Pbso)mentioning

confidence: 99%

Management of patients with BRCA mutation from the point of view of a breast surgeon

Riis

2021

Annals of Medicine &Amp; Surgery

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“…However, the effect of hysterectomies and bilateral salpingo-oophorectomies on the sexual function of women has been a point of contention. Some studies have reported a positive effect of SM on psychological and sexual well-being and sexual performance [10,[29][30][31][32]. Conversely, Kokcu et al found that vaginal dryness increased in women with SM, but that SM did not have a more negative effect on female sexual performance than did NM [33].…”

Section: Clinical Researchmentioning

confidence: 97%

Does Type of Menopause Affect the Sex Lives of Women?

et al. 2020

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The aim of this study was to investigate factors affecting the sex lives of middle-aged women, and whether surgical menopause affects sexual function differently from natural menopause, by comparing effects on sexual performance of women with similar demographic features. Material/Methods:The study included 151 women with surgical menopause (SM), 357 women with natural menopause (NM), and 186 perimenopausal women (PM). The women were asked to complete a 6-question survey of sexual performance parameters. The relationship between the demographic and clinical features and hormone levels of the groups and sexual function parameters were evaluated. We also compared these parameters between the 3 study groups, and paired comparisons were made between the SM group and the NM group. Results:Demographic features, serum DHEA-S, total testosterone, and FSH levels were found to have statistically significant effects on sexual performance of women (p<0.05). The sexual function scores for the frequency of sexual desire, coitus, and orgasm were significantly higher in the PM group, whereas vaginal lubrication scores were lower compared to the NM and SM group (p<0.05). In paired comparison of NM and SM, the scores for the frequency of coitus, orgasm, and vaginal lubrication were significantly higher in the SM group, while sexual desire frequency scores were higher in the NM group (p<0.05). Conclusions:Our study approached to this topic in an extended manner and found significant relationships between several demographic-clinical and hormonal factors. SM was found to not affect female sexual performance, except for sexual desire, more than NM.

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“…Bilateral oophorectomy in pre‐menopausal women — which, in conjunction with bilateral salpingectomy, may be used as a treatment for endometrial and ovarian cancer or may be recommended as a risk‐reduction treatment for pre‐menopausal women at high inherited risk of ovarian or breast cancer (eg, women with a BRCA1 or BRCA2 gene mutation) — induces surgical menopause 12 . Despite the lack of large prospective studies in cancer survivors, surgical menopause appears to cause more frequent and severe vasomotor and sexual symptoms than natural menopause 12 , 13 . Symptoms associated with surgical menopause as treatment for gynaecological cancer or to reduce the risk of breast cancer recurrence may, however, be difficult to distinguish from those associated with adjuvant treatments.…”

Section: Mechanisms Of Cancer‐related Menopausementioning

confidence: 99%

“…12 Despite the lack of large prospective studies in cancer survivors, surgical menopause appears to cause more frequent and severe vasomotor and sexual symptoms than natural menopause. 12,13 Symptoms associated with surgical menopause as treatment for gynaecological cancer or to reduce the risk of breast cancer recurrence may, however, be difficult to distinguish from those associated with adjuvant treatments.…”

Section: Surgical Menopausementioning

confidence: 99%

Managing menopausal symptoms after cancer: an evidence‐based approach for primary care

Marino

McNamara

Hickey

2018

Medical Journal of Australia

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Summary Impaired ovarian function and menopausal symptoms are common after cancer treatment. Menopausal symptoms often occur at an earlier age in women with cancer, and may be more severe than in natural menopause; they may be the most persistent and troubling sequelae of cancer. A third of female patients with cancer report dissatisfaction with the quality and length of physician–patient discussions about reproductive health, including menopause. Systemic menopausal hormone therapy is the most effective treatment for menopausal symptoms, but it is not suitable for all patients after cancer — where it is unsuitable, alternative effective non‐hormonal treatments are available. Effective pharmacological agents available to treat vasomotor symptoms include selective serotonin reuptake inhibitors, serotonin–noradrenaline reuptake inhibitors, clonidine and gabapentin. There is increasing evidence supporting cognitive behavioural therapy for the treatment of vasomotor symptoms, in self‐help or group settings. Vaginal atrophy can be treated with vaginal (topical) oestrogen with minimal systemic absorption; topical vaginal lubricants may help with vaginal dryness and dyspareunia, with some evidence suggesting that silicone‐based products may be more effective than water‐based ones. Bone health may be impaired in post‐menopausal women with cancer or in cancer survivors, particularly in women with treatment‐related menopause or in women receiving anti‐oestrogen therapies; this should be managed in addition to menopausal symptoms. Primary care physicians should be aware of the troublesome and ongoing nature of menopausal symptoms after cancer, should discuss them with all patients after cancer treatment, and should consider treatment or referral to a specialist for appropriate management.

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Impact of risk-reducing salpingo-oophorectomy in premenopausal women

Abstract: The conclusions of this systematic review are limited by the absence of randomized, controlled trials. There is growing evidence from observational studies that RRSO may impact negatively on all-cause non-survival endpoints.

Cited by 46 publications

References 70 publications

Management of patients with BRCA mutation from the point of view of a breast surgeon

Management of patients with BRCA mutation from the point of view of a breast surgeon

Does Type of Menopause Affect the Sex Lives of Women?

Managing menopausal symptoms after cancer: an evidence‐based approach for primary care

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