Impact of rotavirus vaccination on the burden of acute gastroenteritis in Nagoya city, Japan

Yoshikawa, Tetsushi; Matsuki, Taizo; Satô, Keiko; Mizuno, Mihoko; Shibata, Mitsue; Hasegawa, Shinji; Morita, Makoto; Iwasa, Mitsuji; Gopala, Kusuma; Holl, Katsiaryna

doi:10.1016/j.vaccine.2017.12.006

Cited by 18 publications

(17 citation statements)

References 31 publications

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“…consistent with those of our previous study 10 and other reports in Japan. [7][8][9]12 Additionally, the subsequent continuous reduction of hospitalizations until the 2017 season in this age group was demonstrated. In contrast, there was no apparent declining trend in the incidence of hospitalizations in children aged ≥5-<10 years.…”

Section: Discussionmentioning

confidence: 72%

“…So far, a few municipality-level studies have evaluated the impact of RV vaccine on the health of children aged <5 years in Japan. [7][8][9] However, the results do not necessarily indicate a national trend. Hence, our previous study estimated the impact of RV vaccine on RVGE incidences in a large population of children aged <5 during the pre-and post-vaccination periods from 2009 to 2015 using a health insurance claims database.…”

Section: Introductionmentioning

confidence: 68%

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Sustained reduction in rotavirus-coded hospitalizations in children aged <5 years after introduction of self-financed rotavirus vaccines in Japan

Kobayashi

Miyazaki

Tatsumi³

2019

Human Vaccines & Immunotherapeutics

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This is an extension of our previous study, which evaluated the incidence of seasonal rotavirus gastroenteritis (RVGE) hospitalizations in children aged <5 years from 2009 to 2015 in Japan. Here, we evaluated the incidence of RVGE hospitalizations in children aged <10 years during the rotavirus season (January-June) from 2009 to 2017 in Japan, before and after the monovalent and pentavalent rotavirus vaccines were introduced in November 2011 and July 2012, using the same health insurance claims database and study methods. In children aged <5 years, the incidence of RVGE hospitalizations greatly declined in 2014 after vaccine introduction, consistent with our previous findings, and the decline was sustained until 2017. However, in children aged ≥5-<10 years, no apparent trend for a continuous decline in RVGE hospitalizations was observed during the study period. Improved RV vaccination coverage may lead to a further reduction in severe RVGE in Japan.

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Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 68%

Sustained reduction in rotavirus-coded hospitalizations in children aged <5 years after introduction of self-financed rotavirus vaccines in Japan

Kobayashi

Miyazaki

Tatsumi³

2019

Human Vaccines & Immunotherapeutics

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“…Although the high incidence of severe rotavirus disease leads to a substantial burden among Japanese children, 7 vaccination against rotavirus is done on a voluntary basis. 14 The first dose of the HRV vaccine is recommended to be administered during the age interval 6-14 weeks with a schedule of 2 vaccinations with HRV vaccine, or 3 vaccinations with HBRV vaccine.…”

Section: Discussionmentioning

confidence: 99%

“…5 Rotavirus infections accounted for 40-50% of all hospitalizations for AGE. 6,7 The WHO considers rotavirus vaccination as an effective measure to prevent RVGE and recommends it to be done as soon as possible from 6 weeks of age, if possible along with the diphtheriapertussis-tetanus (DPT) vaccination to ensure induction of protection prior to the peak incidence of natural rotavirus infection. 2 Rotavirus vaccines are recommended to be part of all national immunization programs, particularly in countries with high RVGE-associated fatality rates.…”

Section: Introductionmentioning

confidence: 99%

Immunogenicity and safety of the diphtheria, pertussis, tetanus and inactivated poliovirus vaccine when co-administered with the human rotavirus vaccine (Rotarix) in healthy Japanese infants: a phase IV randomized study

Gillard

Tamura

Kuroki³

et al. 2019

Human Vaccines & Immunotherapeutics

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Rotavirus infections have been reported to account for 40–50% of all hospitalized acute gastroenteritis cases in young children (<5 years) in Japan. Since 2011, Rotarix containing the live attenuated human rotavirus RIX4414 strain (HRV) has been licensed in Japan for infants. Vaccination against rotavirus is optional in Japan whereas administration of diphtheria, pertussis, tetanus, and inactivated poliovirus (DPT-IPV) vaccine is part of the national routine immunization program. In this open-label, randomized, controlled, multicenter study, we evaluated the immunogenicity and safety of the DPT-IPV vaccine (Squarekids) administered concomitantly or staggered with the liquid HRV (Rotarix) vaccine in healthy Japanese infants. A total of 292 infants aged 6–12 weeks were randomly assigned to receive DPT-IPV vaccine and HRV vaccine co-administered (n = 147) or staggered (n = 145). Immune responses to DPT-IPV vaccine were evaluated by measuring the post-vaccination serum antibody titers/concentrations to each antigen at one month following the third dose of DPT-IPV vaccine. Seroprotection/seropositivity against each of the diphtheria, pertussis (pertussis toxin and filamentous hemagglutinin), tetanus, and poliovirus type 1, 2 and 3 antigens was 92.8% or higher in both groups. In terms of immunogenicity, DPT-IPV vaccine co-administered with HRV vaccine was shown to be non-inferior to DPT-IPV vaccine with a staggered administration. The safety profile was comparable in the two vaccine groups with no vaccine-related serious adverse events, no deaths and no cases of intussusception. These results support co-administration of HRV vaccine with DPT-IPV vaccine in Japan. ClinicalTrials.gov NCT02907216

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“…10) In Japan, Rotarix ® and RotaTeq ® became available on the private market in November 2011 and July 2012, respectively. Because of the high effectiveness of these vaccines 11,12) and their impact on reducing hospitalization from RVGE, [13][14][15][16] rotavirus vaccine will be included in Japan's NIP in October 2020; however, vaccination is self-paid at present. Additionally, vaccination coverage in Japan is unclear because Japan has no vaccination registry.…”

Section: Introductionmentioning

confidence: 99%

Determinants of self-paid rotavirus vaccination status in Kanazawa, Japan, including socioeconomic factors, parents’ perception, and children’s characteristics

Hara

Koshida

Araki

et al. 2020

Preprint

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Background: Japan’s National Immunization Program does not cover rotavirus vaccine and no government subsidies are available. This study aimed to measure the uptake of and determinants that influenced self-paid rotavirus vaccination, including socioeconomic status and relative poverty.Methods: We conducted a cross-sectional study at health check-ups for all children aged 18 months in Kanazawa, Japan, between December 2017 and July 2018. Community nurses collected information on self-paid vaccination history, parents’ perceptions of and recommendations for rotavirus vaccine, and socioeconomic status in interviews using a unified questionnaire. We used multivariable logistic regression to assess vaccine uptake and possible determinants.Results: In total, 1,282 participants were enrolled. The estimated rotavirus vaccine coverage was 72.9%. Perceptions that rotavirus gastroenteritis was serious and that the rotavirus vaccine was effective, pediatricians’ recommendations, information from the city office, magazine and Internet articles, and higher parental education level were associated with higher rotavirus vaccine uptake. Lower household income was associated with decreased rotavirus vaccine uptake. Vaccine expense, fear of adverse reactions to the vaccine, number of household members and siblings, and children’s characteristics were not correlated with rotavirus vaccination. Poverty was associated with decreased rotavirus vaccine uptake, even after adjustment for other determinants (adjusted odds ratio 0.49, 95% confidence interval: 0.26–0.90).Conclusion: Parents’ perceptions, socioeconomic status, relative poverty, and pediatricians’ recommendations are determinants of vaccination. This study suggests that appropriate information about rotavirus vaccine, subsidies for those of lower socioeconomic status, and national recommendations are necessary to achieve higher coverage.

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Impact of rotavirus vaccination on the burden of acute gastroenteritis in Nagoya city, Japan

Cited by 18 publications

References 31 publications

Sustained reduction in rotavirus-coded hospitalizations in children aged <5 years after introduction of self-financed rotavirus vaccines in Japan

Sustained reduction in rotavirus-coded hospitalizations in children aged <5 years after introduction of self-financed rotavirus vaccines in Japan

Immunogenicity and safety of the diphtheria, pertussis, tetanus and inactivated poliovirus vaccine when co-administered with the human rotavirus vaccine (Rotarix) in healthy Japanese infants: a phase IV randomized study

Determinants of self-paid rotavirus vaccination status in Kanazawa, Japan, including socioeconomic factors, parents’ perception, and children’s characteristics

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