Impact of rotavirus vaccination on child mortality, morbidity, and rotavirus-related hospitalizations in Bolivia

Abstract

The significant decrease in main AGE-related health indicators in children <5years of age after the introduction of rotavirus vaccine provides evidence of a substantial public health impact of rotavirus vaccination in Bolivia, as a measure for protecting children against AGE.

Global impact of rotavirus vaccine introduction on rotavirus hospitalisations among children under 5 years of age, 2008–16: findings from the Global Rotavirus Surveillance Network

“…29 Similarly, in Bolivia, there was a decrease in the proportion of rotavirus gastroenteritis cases occurring by 12 months of age, from 67% in the pre vaccine period to 55% in the postvaccine period. 34 This was also seen in Malawi 35 and in Brazil; data from the latter show the mean age of rotavirus infection increased by more than 7 months after rotavirus vaccine intro duction. 36 Whether this shift in the proportion of rotavirus gastroenteritis cases to older ages is a reflection of improved protection shortly after vaccination, whether this shift will diminish over time as all cohorts up to 5 years of age are vaccinated, or whether the absolute number of rotavirus gastroenteritis cases will change all remain to be seen.…”

Using Routine Health Information Data for Research in Low- and Middle-Income Countries: A Systematic Review

“…RHIS data have been used to evaluate a wide range of interventions, ranging from programs that targeted speci c diseases to interventions or policies that affected multiple types of diseases or health services. These included: the effect of malaria control strategies [30][31][32][33][34][35][36] , user fee exemption policies [37][38][39][40] , health nancing schemes [41][42][43][44] , interventions on health governance [45][46][47][48][49][50][51][52][53] , the administration of new vaccines and vaccination campaigns [54][55][56] , as well as community-level interventions such as approaches to enhance community participation and improve referrals from traditional birth attendants in increasing the demand for maternal and child care [57][58][59] .…”

“…These strategies consisted of exclusion, imputation, interpolation, veri cation, and accounting for missing data in modeling. Exclusion of missing data was the most common practice, and among studies that used this technique, they excluded facilities from the analytic samples 38,41,45,52,65,91,[93][94][95][96][97][98] , restricted the study period based on explicit criteria 54,99 , or applied sensitivity analysis to compare various exclusion criteria 41,100,101 . Imputation methods varied from assigning speci c values to the missing observation 42,86,91,[102][103][104] , to various modeling strategies such as conditional autoregressive model 87 , generalized linear regression 103 , and iterative singular value decomposition 103 .…”

Vaccine Safety and Efficacy in Preventing Rotavirus Infection

“…В странах с низкой детской смертностью от диареи эффективность вакцин Ro-taTeq ™ и Rotarix ™ против тяжелых форм ротавирусного гастроэнтерита оценена как высокая [51,58,59]. Многолетний опыт применения показал, что эффективность ротавирусных вакцин в странах с высокой детской смертностью была существенно ниже [60][61][62][63]. Низкая эффективность вакцин из штаммов ротавируса с генотипом P [8] (Rotarix ™ , RotaTeq ™ ) в клинических исследованиях наблюдается в регионах Африки и Юго-Восточной Азии, в которых большая часть детской популяции восприимчива к циркулирующим штаммам ротавирусов с генотипом P [6].…”