Impact of Rotavirus Vaccination on Hospital-Acquired Rotavirus Gastroenteritis in Children

Anderson, Evan J.; Rupp, Angela; Shulman, Stanford T.; Wang, Deli; Zheng, Xiaotian; Noskin, Gary A.

doi:10.1542/peds.2010-1830

Cited by 47 publications

(28 citation statements)

References 26 publications

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“…Comments of those who would not give hepatitis A included "[I am] not convinced of the need", "[I] feel Hepatitis A vaccinetion is unnecessary at that age", "severity of [the] illness does not warrant vaccination", and the "risk exceeds the benefit in my family (stay at home parent)". Despite evidence of the enormous cost savings and reduction in rotavirus morbidity and incidence in the United States, many physicians in the study appeared to feel that rotavirus vaccination at the individual level was not appropriate in their future progeny [16,17]. It may be that those physicians who practiced in 1999 are biased against the rotavirus vaccine having witnessed the recall of the rotavirus vaccine, Rotashield, due to an association with intussusception.…”

Section: Discussionmentioning

confidence: 93%

Vaccination practices among physicians and their children

Martin¹,

Badalyan²

2012

OJPed

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Section: Discussionmentioning

confidence: 93%

Vaccination practices among physicians and their children

Martin¹,

Badalyan²

2012

OJPed

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“…24,25 Overcrowding as indicated by excess BDOR has been associated with increased hospital infections and patient mortality, [26][27][28] and exposure to BDOR of >10% in excess of the recommended limit of 85% for >6 months has been associated with antidepressant treatment in hospital staff. 29 Overcrowding typically occurs in the winter, when influenza, RSV, pneumococcal disease and rotavirus all circulate together, and can be exacerbated by rapid pathogen spread within the hospital causing high rates of nosocomial infection.…”

Section: Discussionmentioning

confidence: 99%

Improvement in hospital Quality of Care (QoC) after the introduction of rotavirus vaccination: An evaluation study in Belgium

Standaert

Alwan²,

Strens

et al. 2015

Human Vaccines & Immunotherapeutics

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During each winter period hospital emergency rooms and pediatric wards are often overwhelmed by high patient influx with infectious diseases leading to chaotic conditions with poor quality of care (QoC) delivery as a consequence. The conditions could be improved if we were able to better control the influx by introducing for instance better prevention strategies against some of the most frequent infectious diseases. New prevention strategies using vaccination against rotavirus infection were introduced in Belgium in November 2006. We developed a measure of hospital QoC suitable for assessing the impact of pediatric rotavirus vaccination. The study is retrospective collecting routine data on bed and staff management in one pediatric hospital in Belgium. The data were divided in pre-and post-vaccination periods during rotavirus-epidemic and non-epidemic periods. The scores were constructed using Explanatory Factor Analysis (EFA). All patients enrolled were admitted to the pediatric ward over the period from 1 January 2004 to 31 December 2009. The results of the epidemic period indicated that bed-day occupancy, bed-day turnover and unplanned readmissions for acute gastroenteritis were lower in the post-vaccination compared with the pre-vaccination periods. The QoC scores were therefore significantly lower (indicating improved QoC) after the introduction of rotavirus vaccination, compared with pre-vaccination. The data suggests that the reduction in the winter peak of rotavirus-related hospitalizations after the introduction of the vaccine reduces pressure on hospital resources and improves the quality of hospital care. The findings should be further tested in similar settings.

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“…Additionally, in a study investigating levels of RV infection over a 5-y period, no correlation was found between improvement in hand-washing compliance and stringent infection-control practices and decrease in the transmission rate of RV. 12 Vaccination to prevent RV may therefore provide a considerable benefit in preventing similar outbreaks, which can have severe consequences for the quality of healthcare and incur significant additional healthcare costs. Indeed, in a retrospective study investigating change in bed-day occupancy before and after introduction of the RotaTeq ® vaccine in Finland, there was a reduction in bed days for RVGE of between 79% and 92% after introduction of the vaccination program.…”

Section: Challenges In Evaluating Seasonal Infectious Diseasesmentioning

confidence: 99%

Do current cost-effectiveness analyses reflect the full value of childhood vaccination in Europe?

Brüggenjürgen

Lorrot

Sheppard

et al. 2014

Human Vaccines & Immunotherapeutics

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E conomic evaluation of vaccinationprograms can be challenging and does not always fully capture the benefits provided. Reasons for this include the difficulties incurred in accurately capturing the health and economic impact of infectious diseases and how different diseases may interact with each other. Rotavirus infection, for example, peaks at a similar time than other infectious diseases, such as RSV and influenza, which can cause hospital overcrowding and disruption, and may pose a risk to more vulnerable children due to limited availability of isolation facilities. Another challenge, specific to evaluating childhood vaccination, is that QoL cannot be accurately measured in children due to a lack of validated instruments. Childhood diseases also incur a care giver burden, due to the need for parents to take time off work, and this is important to consider. Finally, for diseases such as RVGE, cost-effectiveness analyses in which longer time horizons are considered may not reflect the shortterm benefits of vaccination. Further quantification of the economic impact of childhood diseases is thus required to fully highlight the true benefits of childhood vaccination that may be realized. Herein we explore the limitations of existing economic evaluations for childhood vaccination, and how economic analyses could be better adapted in future.

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Impact of Rotavirus Vaccination on Hospital-Acquired Rotavirus Gastroenteritis in Children

Cited by 47 publications

References 26 publications

Vaccination practices among physicians and their children

Vaccination practices among physicians and their children

Improvement in hospital Quality of Care (QoC) after the introduction of rotavirus vaccination: An evaluation study in Belgium

Do current cost-effectiveness analyses reflect the full value of childhood vaccination in Europe?

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