“…In another study, the predominant genetic change was in the yvqF/vraSR system (41), while Watanabe et al showed that most of the 38 VISA strains recovered from 10 different countries carried a mutated rpoB (42). In most, but not all, cases, the relevant mutated genes appear to be directly or indirectly involved with the biosynthesis/metabolism of the staphylococcal cell wall, specifically, two-component sensory regulatory systems controlling the transcription of genes in cell wall synthesis (32,33,43).…”