Impact of rubella vaccination strategy on the occurrence of congenital rubella syndrome

Lanzieri, Tatiana M.; Pinto, Diana; Prevots, D. Rebecca

doi:10.2223/jped.1692

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…We analyzed national CRS and rubella surveillance data during 1995-2005, and data from three CRS clusters investigated in Brazil during 1999-2002 [9][10][11], using EpiInfo 6.04d. CRS incidence rates were calculated as the number of confirmed or compatible CRS cases over the annual census estimates of the population <1yearold.…”

Section: Discussionmentioning

confidence: 99%

“…Case detection strategies were evaluated using data from three CRS clusters investigated during 1999-2002 [9][10][11]. For this analysis, we compared the PPV of suspected cases resulting from active case finding among newborns in maternity hospitals with the PPV of women with confirmed rubella during pregnancy followed-up to evaluate pregnancy outcome.…”

Section: Congenital Rubella Infectionmentioning

confidence: 99%

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Surveillance of congenital rubella syndrome in Brazil, 1995–2005

Lanzieri

Prevots

Dourado

2015

J Pediatr Infect Dis

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In Brazil, routine childhood rubella vaccination was introduced during 1992?2000 and a campaign targeted to women of childbearing age was conducted during 2001?2002 to accelerate control of congenital rubella syndrome (CRS). Surveillance of CRS was implemented in 2000, to detect CRS cases and evaluate impact of rubella vaccination strategies and an elimination goal was established in 2003. National CRS surveillance data were analyzed to describe CRS incidence and positive predictive value (PPV). International standard CRS case definitions were used. Completeness of coverage was estimated by a capture-recapture method using surveillance data and a retrospective study in maternity hospitals. Case detection strategies were evaluated using data from three CRS clusters investigated in Brazil during 1999?2002. In 2001, CRS incidence was 2.3 per 100,000 children < 1 year of age and PPV was 18%, decreasing to 0.1 and 4%, respectively, in 2004. No new confirmed or compatible cases of CRS were identified in 2005. Of 2,443 suspected CRS cases reported during 1995?2005, 1,889 (77%) were born during 2000?2005. Of these, 1,486 (79%) had one blood sample for IgM testing; 93% (n = 1, 024) within six months of age. A total of 280 (12%) infants had confirmed or compatible CRS, of which 51% (93/184) had fatal outcome. Completeness of coverage was estimated at 7%. PPV of active case finding (63%) was 4.3-fold greater than follow-up of pregnant women with confirmed rubella (15%). Rubella and CRS incidence have declined dramatically in Brazil demonstrating the impact of national rubella control strategies, and representing surveillance challenges in the end-stage of elimination. High routine rubella vaccination coverage and a high-quality surveillance system will be critical to achieve the elimination goal. Active CRS surveillance at maternity and referral tertiary hospitals is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Congenital Rubella Infectionmentioning

confidence: 99%

Surveillance of congenital rubella syndrome in Brazil, 1995–2005

Lanzieri

Prevots

Dourado

2015

J Pediatr Infect Dis

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“…Namun, berdasarkan penelitian terbaru yang dilakukan pada tahun 2005-2015, kasus SRK mengalami penurunan dramatis menjadi kurang dari satukasus per tahun. 5 Data yang dikumpulkan oleh Kementrian Kesehatan RI menunjukkan bahwa dalam periode tahun 2010-2015 terdapat sekitar 30.463 kasus rubela. Pada tahun 2015, tercatat 979 baru dari total 4,89 juta bayi lahir hidup, berdasarkan Rencana Jangka Menengah Program Imunisasi di Indonesia (2015-2019).…”

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Hubungan Penyakit Jantung Bawaan dengan Konfirmasi Serologi Anti Rubela pada Sangkaan Sindrom Rubela Kongenital

Arigayota,

Dimiati,

Herdata

et al. 2023

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Latar belakang. Sindrom rubela kongenital adalah kumpulan gejala akibat infeksi virus rubela selama kehamilan, ditandai trias klasik manifestasi klinis berupa sensory neural hearing loss, abnormalitas ocular, dan penyakit jantung bawaan. Pendekatan diagnosis ditegakkan melalui anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Diagnosis pasti berdasarkan hasil serologi anti rubela. Tujuan. Penelitian ini bertujuan untuk mengetahui hubungan antara penyakit jantung bawaan dengan konfirmasi serologi positif antibodi rubela pada sangkaan sindrom rubela kongenital.Metode. Penelitian ini menggunakan data sekunder Rekam Medis anak usia <12 bulan selama tiga tahun (2019-2021) di Rumah Sakit Umum dr. Zainoel Abidin Banda Aceh.Hasil. Dari 117 subjek yang memenuhi kriteria inklusi dan ekslusi, subjek perempuan 60 (51%), dengan 94 (80%) lahir cukup bulan dan rentang usia ibu saat hamil adalah 20-40 tahun. Terdapat 87 (75%) subjek dengan PJB, dengan15 (83%) subjek memiliki nilai serologi positif. Dari hasil analisis terdapat hubungan signifikan antara kejadian penyakit jantung bawaan dengan konfirmasi positif serologi anti rubela (p=0,018).Kesimpulan. Terdapat hubungan yang signifikan antara manifestasi klinis sindrom rubela kongenital dan penyakit jantung bawaan dengan hasil pemeriksaan konfirmasi serologis positif antibodi rubela.

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“…24 Combined vaccination strategy with a risk population approach for adults (WCBA, college students, health care workers, teachers, military personnel, government employees, and industry employees) and universal vaccination for boys and girls could be more efficient in reducing the incidence of acquired rubella and CRS as observed in Brazil, the US, and Cuba. [26][27][28][29] The review concluded that a combined vaccination strategy with routine vaccination for boys and girls and universal vaccination for adolescents and adults (both men and women), aged 15-39 years, through "speed-up" campaigns, was the most effective strategy. 22 This strategy reduced rubella incidence by more than 98%, and no CRS was reported since 2008 in Mexico and Costa Rica.…”

mentioning

confidence: 99%

Rubella seroprevalence among mothers and incidence of congenital rubella three years after rubella vaccine introduction in Vietnam

Toizumi

Tanaka

Moriuchi

et al. 2021

Human Vaccines & Immunotherapeutics

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Following a rubella outbreak in 2011, Vietnam implemented a mass measles-rubella vaccination campaign for children aged 1-14 years in 2014-2015, further expanding the target age to 16-17 years in 2016; routine vaccination was introduced in 2014. However, there was concern that a substantial proportion of women of child-bearing age were still susceptible to rubella, with the fear of congenital rubella emergence. Thus, we conducted a prospective cohort study in Nha Trang, Vietnam, from 2017-2018 to investigate pregnant women's susceptibility to rubella infection, the incidence of congenital rubella infection, and factors associated with susceptibility. Cord blood was tested for rubella-specific immunoglobulin M (IgM) and IgG; neonatal saliva and cord blood specimens were examined for rubella-RNA. We analyzed 2013 mother-baby pairs. No baby was rubella-IgM or rubella-RNA positive. Overall, 20.4% of mothers were seronegative (95% confidence interval, 18.6%-22.1%). The seronegativity was significantly low among mothers aged <35 years. We found that maternal age groups of 20-24 and 25-29 years, and the lack of self-reported vaccination history were significantly associated with seronegativity. Many pregnant women who were not covered by the vaccination campaign are still at risk of rubella infection.

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Impact of rubella vaccination strategy on the occurrence of congenital rubella syndrome

Cited by 5 publications

References 12 publications

Surveillance of congenital rubella syndrome in Brazil, 1995–2005

Surveillance of congenital rubella syndrome in Brazil, 1995–2005

Hubungan Penyakit Jantung Bawaan dengan Konfirmasi Serologi Anti Rubela pada Sangkaan Sindrom Rubela Kongenital

Rubella seroprevalence among mothers and incidence of congenital rubella three years after rubella vaccine introduction in Vietnam

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