Impact of Sarcopenia as a Prognostic Factor on Reductive Hepatectomy for Advanced Hepatocellular Carcinoma

Omiya, Satoshi; Komatsu, Shohei; Kido, Masahiro; Kuramitsu, Kaori; Gon, Hidetoshi; Fukui, Kenji; Urade, Takeshi; So, Shinichi; Sofue, Keitaro; Yano, Yoshihiko; Sakai, Yoshitada; Yanagimoto, Hiroaki; Toyama, Hirochika; Ajiki, Tetsuo; Fukumoto, Takumi

doi:10.21873/anticanres.15394

Cited by 6 publications

(3 citation statements)

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“…'Lifestyle' covers various aspects, including the physical exercise and dietary habits. Recently, sarcopenia (muscle volume loss) has been recognized as a clinically important factor, and the importance of exercise is being increasingly recognized (21)(22)(23)(24). However, factors associated with the dietary habit are less frequently assessed, and in particular, changes in appetite-related hormones in response to HCV elimination have barely been examined.…”

Section: Discussionmentioning

confidence: 99%

Possible Alterations in Appetite-related Molecules After the Elimination of Hepatitis C Virus

Shimono¹,

Enomoto²,

Aizawa³

et al. 2022

In Vivo

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Background/Aim: Recent advances in antiviral treatment have achieved a sustained viral response (SVR) in over 95% of hepatitis C virus (HCV) infections. HCV elimination is suggested to improve several lifestyle-related factors; however, few studies have focused on dietary habit-/appetite-related factors. Patients and Methods: HCV-infected patients who received Daclatasvir/Asnaprevir (DCV/ASV) therapy were enrolled, and the changes in appetite-related molecules after antiviral therapy were assessed with a multiple cytokine-measuring system. Results: Among 119 HCV-infected patients who received DCV/ASV treatment, 104 (87.3%) achieved an SVR. In the SVR group, DCV/ASV treatment improved several liver-related variables at 24 weeks after the completion of therapy. In patients with an SVR, the values of glucagon-like peptide 1 (GLP-1) and leptin were significantly increased at 24 weeks after completing directacting antiviral therapy. However, no significant change was observed in non-SVR patients, regardless of the receipt of direct-acting antiviral treatment. Conclusion: Gastrointestinal hormones related to the dietary habit and/or appetite may be influenced by HCV elimination.

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Section: Discussionmentioning

confidence: 99%

Possible Alterations in Appetite-related Molecules After the Elimination of Hepatitis C Virus

Shimono¹,

Enomoto²,

Aizawa³

et al. 2022

In Vivo

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“…Several studies have reported that sarcopenia is associated with poor prognosis in cancer patients, including those with HCC (23)(24)(25)(26)(27)(28). In previous studies, it was demonstrated that sarcopenia, defined by CT images as low-skeletal muscle area (LSMM) or low muscle density, is of prognostic relevance in patients with HCC undergoing transarterial chemoembolization (29,30).…”

mentioning

confidence: 99%

The Apparent Diffusion Coefficient of the Paraspinal and Psoas Muscles Are of Prognostic Relevance in Patients With Hepatocellular Carcinoma Undergoing Transarterial Radioembolization

EHRENGUT,

SCHINDLER,

SEEHOFER

et al. 2024

CDP

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Background/Aim: Transarterial radioembolization (TARE) is a treatment option for early or intermediate stage hepatocellular carcinoma (HCC). Sarcopenia is defined as loss of muscle strength and quality which can be estimated by imaging modalities and has been associated with prognosis and treatment response in HCC patients. Apparent diffusion coefficient (ADC) values derived from diffusion-weighted imaging (DWI) can reflect the tissue composition and might be better to determine muscle changes of sarcopenia than the standard method of computed tomography (CT). The present study sought to elucidate ADC values of the abdominal wall muscles as a prognostic factor in patients undergoing TARE. Patients and Methods: A retrospective analysis was performed between 2016 and 2020. Overall, 52 patients, 9 women (17.3%) and 43 men (82.7%), with a mean age of 69±8.5 years were included into the analysis. In every case, the first pre-interventional magnetic resonance imaging (MRI) including DWI was used to measure the ADC values of paraspinal and psoas muscle. The 12-month survival after TARE was used as the primary study outcome. Results: Overall, 40 patients (76.9%) of the patient cohort died within the 12-month observation period. Mean overall survival was 10.9 months after TARE for all patients. Mean ADC values for all muscles were 1.31±0.13×10–3mm2/s. The ADC values of the paraspinal muscles were statistically significantly higher compared to the ADC values of the psoas muscles (p=0.0031). A positive correlation was identified between mean ADC and the thrombocyte count (r=0.37, p=0.005) and serum bilirubin (r=–0.30, p=0.03). In the multivariate Cox regression analysis, the mean ADC values of all muscles were associated with the survival after 12 months (HR=0.98, 95% CI=0.97-0.99, p=0.04). Conclusion: ADC values of the abdominal wall muscles could be used as a prognostic biomarker in patients with HCC undergoing TARE. These preliminary results should be confirmed by further studies using external validation cohorts and other treatment modalities.

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“…The Chinese scholars, Cao et al ( 7 ), analyzed the clinical data of 139 patients with liver cancer who underwent hepatectomy, and observed that the incidence of severe postoperative complications (Clavien-Dindo grade III and above) (19.6% vs. 6.0%) and total complications (35.7% vs. 13.3%) were significantly higher than non-sarcopenia patients (P<0.05). In additional radical surgery, Omiya et al ( 8 ) demonstrated that sarcopenia was a poor prognostic factor of survival after reductive hepatectomy in advanced hepatocellular carcinoma patients (P=0.049).…”

mentioning

confidence: 99%

Perioperative management of patients with liver cancer complicated with sarcopenia

Xing¹,

Wan²,

Sang³

et al. 2022

Hepatobiliary Surg Nutr

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Primary liver cancer is one of the most common digestive system malignancies worldwide, with hepatocellular carcinomas accounting for about 90% of cases. It has a concealed onset, rapid progression, high degree of malignancy, and is difficult to treat, which presents a serious threat to people's life and health (1). At present, the primary treatment methods for liver cancer include hepatectomy, liver transplantation, transcatheter arterial chemoembolization, systematic treatment, and combined therapy, among which surgical resection is the most important (2,3).The previously reported prognostic variables affecting liver cancer resection included age, performance status, tumor number, body mass index (BMI), and other factors, which significantly improved the incidence of postoperative complications and the long-term survival rate of liver cancer patients. However, sarcopenia is being gradually explored and studied as a new prognostic factor. Sarcopenia refers to a degenerative loss of muscle mass, strength, and function, with a prevalence of between 11% and 30% in patients undergoing surgery for digestive system cancers (4).At present, numerous studies have shown that sarcopenia is an independent risk factor for poor short-and long-term prognosis after hepatectomy for liver cancer. Berardi et al. (5) recently reported on 234 patients undergoing hepatectomy for liver cancer in the JAMA Surgery and analyzed the relationship between sarcopenia and short-term prognosis after hepatectomy. Their study pointed out that sarcopenia was associated with poor short-term prognosis following malignant liver tumor resection, especially in terms of 90-

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Impact of Sarcopenia as a Prognostic Factor on Reductive Hepatectomy for Advanced Hepatocellular Carcinoma

Cited by 6 publications

References 0 publications

Possible Alterations in Appetite-related Molecules After the Elimination of Hepatitis C Virus

Possible Alterations in Appetite-related Molecules After the Elimination of Hepatitis C Virus

The Apparent Diffusion Coefficient of the Paraspinal and Psoas Muscles Are of Prognostic Relevance in Patients With Hepatocellular Carcinoma Undergoing Transarterial Radioembolization

Perioperative management of patients with liver cancer complicated with sarcopenia

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