2023
DOI: 10.1111/dom.15243
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Impact of sarcosine on diabetic retinopathy: Findings based on weighted gene co‐expression network analysis and machine learning techniques

Mingzhu Che,
Zhezheng Xia,
Depeng Jiang
et al.

Abstract: AimTo quantify the association between serum sarcosine and diabetic retinopathy (DR) using weighted gene co‐expression network analysis (WGCNA).MethodsWe measured serum metabolites in 69 pairs of type 2 diabetes (T2D) patients with and without DR matched by age, gender, body mass index(BMI and HbA1c, using a propensity score matching‐based approach. To identify modules and metabolites linked to DR, pathway analysis was performed using WGCNA, the Kyoto Encyclopedia of Genes and Genomes and Small‐Molecule Pathwa… Show more

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