Impact of schistosomiasis on patient and graft outcome after renal transplantation: 10 years' follow‐up

Mahmoud, Khaled; Sobh, Mohamed; El‐Agroudy, Amgad E.; Mostafa, Fatma; Baz, M.; Shokeir, A. A.; Ghoneim, Mohamed A.

doi:10.1093/ndt/16.11.2214

Cited by 52 publications

(39 citation statements)

References 14 publications

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“…The interplay between high schistosomal infection among our transplant population [13, 14, 15, 16]and HCV infection may be the contributing factor. The prevalence of HCV infection in our patients on hemodialysis is high, reaching 60% [13].…”

Section: Discussionmentioning

confidence: 99%

Death with Functioning Graft in Living Donor Kidney Transplantation: Analysis of Risk Factors

et al. 2003

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Background: Death with a functioning graft (DWF) has been reported as a major cause of graft loss after renal transplantation. It has been reported to occur in 9–30%. Methods: From March 1976 to January 2002, a total of 1,400 living donor renal transplants were performed in our center. Out of 257 reported deaths among our patients, 131 recipients died with functioning grafts after a mean period of 53.4 ± 53.2 months. Results: DWF patients account for 27% of all graft losses in our series. The mean age was 34.9 + 10.6 (range 8–62 years), 98 of them were male and 33 were female. The original kidney disease was GN in 9, PN in 24, PCK in 5 and nephrosclerosis in 8 patients. Acute rejection episodes were diagnosed in 84 patients (63.1). The post-transplant complications encountered were hypertension in 78 patients (59.5%), diabetes mellitus in 30 patients (22.9%), medical infections in 68 (51.5%), hepatic complications in 30 (22.9%) and malignancy in 17 patients (13%). The main causes of death in these patients were infections in 46 (35.6%), cardiovascular in 23 (17.6%), liver cell failure in 15 patients (11.4%) and malignancy in 8 (6.1%). The mean serum creatinine was 2 ± 0.6 mg/dl at last follow-up before death. Conclusion: We conclude that the relatively higher mortality in renal transplantation is, in part, due to co-morbid medical illness, pre-transplant dialysis treatment, and factors uniquely related to transplantation, including immunosuppression and other drug effects. DWF must be in consideration when calculating graft survival.

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Section: Discussionmentioning

confidence: 99%

Death with Functioning Graft in Living Donor Kidney Transplantation: Analysis of Risk Factors

et al. 2003

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“…An increase in acute and chronic rejection was not observed either. Infected patients (both live donors and recipients) should be diagnosed and treated correctly with praziquantel before transplantation (236).…”

Section: Infections Caused By Trematodesmentioning

confidence: 99%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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SUMMARY In recent years, the increasing number of donors from different regions of the world is providing a new challenge for the management and selection of suitable donors. This is a worldwide problem in most countries with transplantation programs, especially due to the increase in immigration and international travel. This paper elaborates recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients. For this purpose, an extensive review of the medical literature focusing on viral, fungal, and parasitic infections that could be transmitted during transplantation from donors who have lived or traveled in countries where these infections are endemic has been performed, with special emphasis on tropical and imported infections. The review also includes cases described in the literature as well as risks of transmission during transplantation, microbiological tests available, and recommendations for each infection. A table listing different infectious agents with their geographic distributions and specific recommendations is included.

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“…mansoni infection of the gastrointestinal tract. In a large Egyptian study of 243 living related renal transplants, no association was found between outcome and pretransplant schistosomal infection of donor or recipient 23. Higher urological complication rates were found in the infected groups, but no increase in Schistosoma reinfection rate was recorded in the 10‐year follow‐up.…”

Section: Discussionmentioning

confidence: 92%

Hepatic and intestinal schistosomiasis after orthotopic liver transplant

et al. 2005

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Impact of schistosomiasis on patient and graft outcome after renal transplantation: 10 years' follow‐up

Cited by 52 publications

References 14 publications

Death with Functioning Graft in Living Donor Kidney Transplantation: Analysis of Risk Factors

Death with Functioning Graft in Living Donor Kidney Transplantation: Analysis of Risk Factors

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Hepatic and intestinal schistosomiasis after orthotopic liver transplant

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