Impact of SDF-1 and AMD3100 on Hair Follicle Dynamics in a Chronic Stress Model
Yinglin Zhao,
Wenzi Liang,
Zhehui Liu
et al.
Abstract:Chronic stress is a common cause of hair loss, involving inflammatory responses and changes in cellular signaling pathways. This study explores the mechanism of action of the SDF-1/CXCR4 signaling axis in chronic stress-induced hair loss. The research indicates that SDF-1 promotes hair follicle growth through the PI3K/Akt and JAK/STAT signaling pathways. Transcriptome sequencing analysis was conducted to identify differentially expressed genes in the skin of normal and stressed mice, with key genes SDF-1/CXCR4… Show more
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