Impact of selected pro-inflammatory cytokines and oxidative stress on carcinogenesis and progression of prostate and colorectal adenocarcinomas

Fryczkowski, Michal; Hejmo, Tomasz; Bułdak, Magdalena; Stachowska, Marta; Żwirska-Korczala, K; Rokicka, Joanna

doi:10.18794/aams/110503

Cited by 4 publications

(3 citation statements)

References 93 publications

(102 reference statements)

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“…Similar to other cancer diseases, oesophageal cancer (EC) is characterised by the presence of chronic oxidative stress, which triggers inflammation and results from intense metabolism due to continuous cell proliferation and mutations in mitochondrial DNA [ 166 ]. Oxidative stress not only leads to the occurrence of inflammatory reactions but also activates the transcription of genes for various inflammatory factors, depending on proteins from the nuclear factor κB (NF-κB) family [ 167 ].…”

Section: The Effect Of Polyphenols On Endometrial Cancermentioning

confidence: 99%

Polyphenols Influence the Development of Endometrial Cancer by Modulating the Gut Microbiota

Baranowska-Wójcik,

Winiarska-Mieczan,

Olcha

et al. 2024

Nutrients

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Dysbiosis of the microbiota in the gastrointestinal tract can induce the development of gynaecological tumours, particularly in postmenopausal women, by causing DNA damage and alterations in metabolite metabolism. Dysbiosis also complicates cancer treatment by influencing the body’s immune response and disrupting the sensitivity to chemotherapy drugs. Therefore, it is crucial to maintain homeostasis in the gut microbiota through the effective use of food components that affect its structure. Recent studies have shown that polyphenols, which are likely to be the most important secondary metabolites produced by plants, exhibit prebiotic properties. They affect the structure of the gut microbiota and the synthesis of metabolites. In this review, we summarise the current state of knowledge, focusing on the impact of polyphenols on the development of gynaecological tumours, particularly endometrial cancer, and emphasising that polyphenol consumption leads to beneficial modifications in the structure of the gut microbiota.

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Section: The Effect Of Polyphenols On Endometrial Cancermentioning

confidence: 99%

Polyphenols Influence the Development of Endometrial Cancer by Modulating the Gut Microbiota

Baranowska-Wójcik,

Winiarska-Mieczan,

Olcha

et al. 2024

Nutrients

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“…However, mediators released by tumor-infiltrating cells are initially an important weapon in the fight against cancer, but their long-term action may have the opposite effect [54,55]. Among the main pro-inflammatory cytokines in the TME are interleukins (IL), e.g., IL-1β, IL-6, and IL-8 (CXCL-8) and tumor necrosis factor α (TNF-α) [56].…”

Section: Soluble Mediatorsmentioning

confidence: 99%

Characteristics of the Colorectal Cancer Microenvironment—Role in Cancer Progression and Therapeutic Possibilities

Pieniądz,

Pięt,

Paduch

2024

Applied Sciences

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Colorectal cancer (CRC) is one of the most common and deadliest cancers worldwide. According to the GLOBOCAN (WHO) report in 2020, nearly 2 million patients were diagnosed globally. Despite the advances in cancer diagnosis and therapy, CRC remains a global challenge. Recently, attention has been paid to the tumor microenvironment (TME), which constitutes a significant part of the tumor and mainly includes various immune cells, fibroblasts, vascular cells, and extracellular elements, such as the extracellular matrix (ECM). Many components of the stroma initially exert an anti-tumor effect, but over time, they undergo functional transformation into elements that promote tumor growth. As a result, conditions conducive to further cancer development, invasion into local tissues, and distant metastasis arise. The microenvironment of colorectal cancer (CRC) may be an important direction in the search for therapeutic targets, but it requires further understanding. The main purpose of our review is to explain the role of the complex CRC microenvironment in the progression of this cancer and highlight the potential of targeted therapy directed at the TME. Therefore, continued research into its components and typical biomarkers is necessary to improve therapy and enhance the quality of life for patients.

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“…High concentrations of ROS in tumour cells may also induce cellular adaptation, increased rates of proliferation, DNA mutations and genome instability, as well as the development of resistance to certain groups of drugs used in cancer therapy, which further stimulates tumour growth [ 48 ]. Similarly to other cancers, EC entails chronic oxidative stress ( Table 1 ), primarily due to the development of inflammation and the activity of cytokines, as well as oncogenic signalling, intensive metabolism due to continuous proliferation, mutations in the mitochondrial DNA, and dysfunctions of the respiratory chain [ 49 ].…”

Section: Oxidative Stress In Endometrial Cancermentioning

confidence: 99%

Antioxidative, Anti-Inflammatory, Anti-Obesogenic, and Antidiabetic Properties of Tea Polyphenols—The Positive Impact of Regular Tea Consumption as an Element of Prophylaxis and Pharmacotherapy Support in Endometrial Cancer

Olcha

Winiarska-Mieczan

Kwiecień

et al. 2022

IJMS

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Endometrial cancer (EC) is second only to cervical carcinoma among the most commonly diagnosed malignant tumours of the female reproductive system. The available literature provides evidence for the involvement of 32 genes in the hereditary incidence of EC. The physiological markers of EC and coexisting diet-dependent maladies include antioxidative system disorders but also progressing inflammation; hence, the main forms of prophylaxis and pharmacotherapy ought to include a diet rich in substances aiding the organism’s response to this type of disorder, with a particular focus on ones suitable for lifelong consumption. Tea polyphenols satisfy those requirements due to their proven antioxidative, anti-inflammatory, anti-obesogenic, and antidiabetic properties. Practitioners ought to consider promoting tea consumption among individuals genetically predisposed for EC, particularly given its low cost, accessibility, confirmed health benefits, and above all, suitability for long-term consumption regardless of the patient’s age. The aim of this paper is to analyse the potential usability of tea as an element of prophylaxis and pharmacotherapy support in EC patients. The analysis is based on information available from worldwide literature published in the last 15 years.

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Impact of selected pro-inflammatory cytokines and oxidative stress on carcinogenesis and progression of prostate and colorectal adenocarcinomas

Cited by 4 publications

References 93 publications

Polyphenols Influence the Development of Endometrial Cancer by Modulating the Gut Microbiota

Polyphenols Influence the Development of Endometrial Cancer by Modulating the Gut Microbiota

Characteristics of the Colorectal Cancer Microenvironment—Role in Cancer Progression and Therapeutic Possibilities

Antioxidative, Anti-Inflammatory, Anti-Obesogenic, and Antidiabetic Properties of Tea Polyphenols—The Positive Impact of Regular Tea Consumption as an Element of Prophylaxis and Pharmacotherapy Support in Endometrial Cancer

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