Impact of Selenium Supplementation in Neutropenia and Immunoglobulin Production in Childhood Cancer Patients

Rocha, Katya Cristina; Vieira, Maria Luíza; Beltrame, Registila Libania; Cartum, Jairo; Alves, Sarah; Azzalis, Ligia Ajaime; Junqueira, Virgínia Berlanga Campos; Pereira, Edimar Cristiano; Fonseca, Fernando Luiz Affonso

doi:10.1089/jmf.2015.0145

Cited by 38 publications

(37 citation statements)

References 47 publications

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“…The idea that selenium supplementation may be used to support the immune system during cancer treatment has been supported by some studies including those related to childhood leukemia and neutropenia [ 158 , 159 ]. Intervention studies showed positive effects of selenium on mitigating neutropenia in children suffering from leukemia/lymphomas as well as solid tumors [ 160 ].…”

Section: Selenium and Its Effects On A Shift Toward Anti-cancer Immentioning

confidence: 99%

Selenium, Selenoproteins, and Immunity

2018

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Selenium is an essential micronutrient that plays a crucial role in development and a wide variety of physiological processes including effect immune responses. The immune system relies on adequate dietary selenium intake and this nutrient exerts its biological effects mostly through its incorporation into selenoproteins. The selenoproteome contains 25 members in humans that exhibit a wide variety of functions. The development of high-throughput omic approaches and novel bioinformatics tools has led to new insights regarding the effects of selenium and selenoproteins in human immuno-biology. Equally important are the innovative experimental systems that have emerged to interrogate molecular mechanisms underlying those effects. This review presents a summary of the current understanding of the role of selenium and selenoproteins in regulating immune cell functions and how dysregulation of these processes may lead to inflammation or immune-related diseases.

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Section: Selenium and Its Effects On A Shift Toward Anti-cancer Immentioning

confidence: 99%

Selenium, Selenoproteins, and Immunity

2018

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“…For example, inosine strongly enhances proliferation of human melanoma cells ( 43 ), and altered ratio of adenosine to inosine has been widely noticed in cancer cells, affecting growth, invasiveness, and metastasis ( 44 , 45 ). Meanwhile, purines serve as potent modulators in the response of immune cells and cytokine release via various receptor subtypes, such as P2X ligand-gated ion channels and G protein-coupled P2Y receptors ( 46 , 47 ), which is substantially involved in the development of oncogenesis and tumorigenesis ( 48 – 51 ). For example, adenosine plays a role in the regulation of neutrophil function and modulates the interaction of neutrophils with pathogens ( 52 ).…”

Section: Purine Metabolism In Cancersmentioning

confidence: 99%

Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy

et al. 2018

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Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer. The de novo biosynthesis of purine depends on six enzymes to catalyze the conversion of phosphoribosylpyrophosphate to inosine 5′-monophosphate. These enzymes cluster around mitochondria and microtubules to form purinosome, which is a multi-enzyme complex involved in de novo purine biosynthesis and purine nucleotides requirement. In this review, we highlighted the purine metabolism and purinosome biology with emphasis on the therapeutic potential of manipulating of purine metabolism or purinosome in cancers. We also reviewed current advances in our understanding of mammalian target of rapamycin for regulating purinosome formation or purine metabolism in cancers and discussed the future prospects for targeting purinosome to treat cancers.

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“…Hospital patients may present with Se deficiency symptoms when maintained with parenteral feeding without Se for a long period of time [6][7][8]. Rocha et al (2016) found that supplementation with Se reduced neutropenic cases (leukemia/lymphomas (LL) and solid tumors (ST) in patients), reduced IgG and IgA levels in LL, and increased IgG and IgA levels in the ST group [9]. Freitas et al (2014) also showed that prematurity and low birth weight could contribute to low blood selenium in premature infants.…”

Section: Introductionmentioning

confidence: 99%

Effect of Selenium Source and Level on Performance, Egg Quality, Egg Selenium Content, and Serum Biochemical Parameters in Laying Hens

Fang

et al. 2020

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The objective of this study was to compare the effect of sodium selenite (SS) and selenium yeast (SY) on performance, egg quality, and selenium concentration in eggs and serum biochemical indices in laying hens. Seven hundred twenty healthy Roman laying hens (21 weeks old, 18 weeks in lay) with a similar laying rate (90.27% ± 1.05%) were randomly divided into 5 groups with 6 replicates of 24 hens each. Five diets were prepared as a 1+2×2 factorial arrangement with control and two sources of Se at two levels. Control diet (control) was prepared without adding exogenous selenium (analyzed basal Se content of 0.178 mg/kg). The other four diets were prepared with the control diet supplemented with SY or SS at 0.3 mg/kg (low; L) or 0.5 mg/kg (high; H) to give 5 diets designated as control, SY-L, SY-H, SS-L, and SS-H. The analyzed selenium content in the SY-L, SY-H, SS-L, and SS-H diets were 0.362, 0.572, 0.323, and 0.533 mg/kg respectively. The pre-trial period lasted 7 d, and the experimental period lasted 56 d (30 weeks old), during which the egg production, egg quality, and hen serum parameters were measured. Results showed that selenium source and level had no effect (P > 0.05) on average daily egg weight and feed conversion ratio (FCR). However, the laying rate was different at the L and H levels of supplementation, regardless of source, such that hens that were supplemented had a higher performance than that of the control, and the H level of supplementation lead to a higher laying rate than that of the L level (P < 0.05). There was a difference in average daily feed intake (ADFI) with an interaction in selenium source and level (P < 0.05), such that SS-L was higher than other selenium supplemented treatment or control. There were no significant differences in egg quality (P > 0.05); at the high level, SY had higher egg yolk selenium compared with SS. However, within SY, adding 0.5 mg/kg selenium led to higher egg yolk selenium than 0.3 mg/kg selenium (P < 0.05). Moreover, adding 0.3 mg/kg SY, 0.3 mg/kg, or 0.5 mg/kg SS to the basal diet had no significant effect on the selenium content in the egg (P > 0.05). There were no significant differences in serum biochemical indices among the five groups (P > 0.05). In conclusion, adding a high level of selenium in the diet of laying hens significantly increased egg production, and addition of a high level of selenium in the form of SY led to a higher deposition of selenium in the yolk than that of SS. These results indicate that adding 0.5 mg/kg of SY in the diet of laying hens would result in Se-enriched eggs.

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Impact of Selenium Supplementation in Neutropenia and Immunoglobulin Production in Childhood Cancer Patients

Cited by 38 publications

References 47 publications

Selenium, Selenoproteins, and Immunity

Selenium, Selenoproteins, and Immunity

Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy

Effect of Selenium Source and Level on Performance, Egg Quality, Egg Selenium Content, and Serum Biochemical Parameters in Laying Hens

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