Impact of semen-derived amyloid (SEVI) on sperm viability and motility: its implication in male reproductive fitness

Kumar, Vijay; Kumar, Pradeep; Yadav, Jay Kant

doi:10.1007/s00249-019-01391-2

Cited by 4 publications

(2 citation statements)

References 69 publications

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“…PSAP dephosphorylates macromolecules in acidic conditions (pH 4-6), but its physiological substrates are not fully known [1,2]. PSAP is assumed to directly influence sperm motility and viability [3]. Alternative splicing generates three types of PSAP transcripts, namely, a transmembrane PSAP, a secretory PSAP, and a cellular PSAP.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Role and Prognostic Impact of PSAP Immunohistochemistry: A Tissue Microarray Study on 31,358 Cancer Tissues

Tribian,

Lennartz,

Höflmayer

et al. 2023

Diagnostics

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Prostate-specific acid phosphatase (PSAP) is a marker for prostate cancer. To assess the specificity and prognostic impact of PSAP, 14,137 samples from 127 different tumor (sub)types, 17,747 prostate cancers, and 76 different normal tissue types were analyzed via immunohistochemistry in a tissue microarray format. In normal tissues, PSAP staining was limited to the prostate epithelial cells. In prostate cancers, PSAP was seen in 100% of Gleason 3 + 3, 95.5% of Gleason 4 + 4, 93.8% of recurrent cancer under androgen deprivation therapy, 91.0% of Gleason 5 + 5, and 31.2% of small cell neuroendocrine cancer. In non-prostatic tumors, PSAP immunostaining was only found in 3.2% of pancreatic neuroendocrine tumors and in 0.8% of diffuse-type gastric adenocarcinomas. In prostate cancer, reduced PSAP staining was strongly linked to an advanced pT stage, a high classical and quantitative Gleason score, lymph node metastasis, high pre-operative PSA levels, early PSA recurrence (p < 0.0001 each), high androgen receptor expression, and TMPRSS2:ERG fusions. A low level of PSAP expression was linked to PSA recurrence independent of pre- and postoperative prognostic markers in ERG-negative cancers. Positive PSAP immunostaining is highly specific for prostate cancer. Reduced PSAP expression is associated with aggressive prostate cancers. These findings make PSAP a candidate marker for prognostic multiparameter panels in ERG-negative prostate cancers.

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Section: Introductionmentioning

confidence: 99%

Diagnostic Role and Prognostic Impact of PSAP Immunohistochemistry: A Tissue Microarray Study on 31,358 Cancer Tissues

Tribian,

Lennartz,

Höflmayer

et al. 2023

Diagnostics

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“…Of course, it is not the only factor responsible for compromising the fertilizing potential of mammalian spermatozoa and it is important not to overstate the case. Many other factors are potentially involved in suppressing a function such as sperm motility, including excess intracellular calcium [23], dephosphorylation of phosphatidyl-inositol-3-kinase [24,25], exposure to motility-inhibiting proteins in semen, including seminal amyloid [26] and seminogelin [27], and exposure to sperm immobilizing antibodies [28]. However, the relative significance of oxidative stress as a major factor in the aetiology of defective sperm function has been clearly demonstrated in the few antioxidant studies that have included measures of lipid peroxidation (malondialdehyde [MDA]) in their evaluation schedule as well as a placebo control group [29].…”

Section: Introductionmentioning

confidence: 99%

The Importance of Oxidative Stress in Determining the Functionality of Mammalian Spermatozoa: A Two-Edged Sword

2020

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This article addresses the importance of oxidative processes in both the generation of functional gametes and the aetiology of defective sperm function. Functionally, sperm capacitation is recognized as a redox-regulated process, wherein a low level of reactive oxygen species (ROS) generation is intimately involved in driving such events as the stimulation of tyrosine phosphorylation, the facilitation of cholesterol efflux and the promotion of cAMP generation. However, the continuous generation of ROS ultimately creates problems for spermatozoa because their unique physical architecture and unusual biochemical composition means that they are vulnerable to oxidative stress. As a consequence, they are heavily dependent on the antioxidant protection afforded by the fluids in the male and female reproductive tracts and, during the precarious process of insemination, seminal plasma. If this antioxidant protection should be compromised for any reason, then the spermatozoa experience pathological oxidative damage. In addition, situations may prevail that cause the spermatozoa to become exposed to high levels of ROS emanating either from other cells in the immediate vicinity (particularly neutrophils) or from the spermatozoa themselves. The environmental and lifestyle factors that promote ROS generation by the spermatozoa are reviewed in this article, as are the techniques that might be used in a diagnostic context to identify patients whose reproductive capacity is under oxidative threat. Understanding the strengths and weaknesses of ROS-monitoring methodologies is critical if we are to effectively identify those patients for whom treatment with antioxidants might be considered a rational management strategy.

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The semenogelin I-derived peptide SgI-52 in seminal plasma participates in sperm selection and clearance by macrophages

Zhao

et al. 2022

Peptides

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Impact of semen-derived amyloid (SEVI) on sperm viability and motility: its implication in male reproductive fitness

Cited by 4 publications

References 69 publications

Diagnostic Role and Prognostic Impact of PSAP Immunohistochemistry: A Tissue Microarray Study on 31,358 Cancer Tissues

Diagnostic Role and Prognostic Impact of PSAP Immunohistochemistry: A Tissue Microarray Study on 31,358 Cancer Tissues

The Importance of Oxidative Stress in Determining the Functionality of Mammalian Spermatozoa: A Two-Edged Sword

The semenogelin I-derived peptide SgI-52 in seminal plasma participates in sperm selection and clearance by macrophages

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