Impact of Serum Phosphate in Mechanically Ventilated Patients With Severe Sepsis and Septic Shock

Miller, Christopher; Doepker, Bruce; Springer, Andrew N; Exline, Matthew C.; Phillips, Gary; Murphy, Claire V.

doi:10.1177/0885066618762753

Cited by 48 publications

(67 citation statements)

References 23 publications

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“…About 90% of critically ill patients have low concentrations of total calcium, and 15-20% of these patients have hypocalcemia (based on iCa) [25]. Similarly, hypomagnesemia is common in critically ill patients with coexisting electrolyte abnormalities [26], while hypo-and hyperphosphatemia are common in patients with severe sepsis and septic shock [27].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Ionized Calcium Levels in Neonatal Sepsis

2020

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Ionized Calcium Levels in Neonatal Sepsis

2020

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“…Miller ve ark. [15] yaptıkları çalışmada sepsis ve septik şoktaki hastalarda hiperfosfatemiyi 28 günlük hastane içi mortalitenin artışıyla ilişkili bulmuşlardır. Bu çalışmada referans değer olarak alt sınır 2,5 mg/dL olarak alınmıştır, bu bizim çalışmamızda aldığımız referans değer ile aynıdır.…”

Section: Discussionunclassified

“…Septik şoktaki hastalarda hiperfosfatemi hücre ölümüne neden olabilir fakat hiperfosfateminin direkt toksisitesi daha da muhtemeldir [15] . Fakat YBÜ'de yatan hastalar için bu bilgi sınırlıdır, vasküler inflamasyon, mitokondrial disfonksiyon nedenli oluşan reaktif oksijen türleri, anemi, iskemi artışı ve yüksek kalsiyum nedenli kardiyovasküler hastalıkları içeren çeşitli nedenler fosfat üretimine neden olabilir [19][20][21][22] .…”

Section: Discussionunclassified

The Effects of Serum Phosphate on 28-day Mortality in Patients Hospitalized in the Intensive Care Unit, Treated with Mechanical Ventilator Therapy and Treated with CRRT for Septic Shock-Induced Acute Kidney Injury

Kaçar¹,

Uzundere²,

Kandemir³

et al. 2020

GKDA

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Fosfat sinyal iletimini, enerji üretimini ve mineral metabolizmasını içeren düzenleyici çoklu metabolik olayda yer alan esansiyel bir mineraldir. Biz bu çalışmada hastaların serum fosfat düzeylerinin fosfat referans değeri olarak verilen 2,5-4,5 mg/dL alt ve üst sınırlarından sapmasının 28 günlük mortalite üzerine etkisini araştırmayı planladık. Yöntem: Hastanemiz başhekimliğinden yazılı izin alındıktan sonra hasta dosyaları retrospektif olarak taranarak yoğun bakım ünitemizde yatan septik şok ilişkili akut böbrek hasarı nedenli sürekli renal replasman tedavisi gören ve 18 yaş üstü 53 adet hasta çalışmaya dahil edildi. Hastanemiz biokimya laboratuarındaki serum fosfat düzeyi referans arlığı 2,5-4,5 mg/dL olduğundan hastaların ortalama serum fosfat düzeylerinin alt sınır referans aralığı olan 2,5 mg/dL ve üst sınır referans aralığı olan 4,5 mg/dL'ye göre istatistiksel değişimleri hesaplandı.

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“…As we all know, patients often have electrolyte disturbances during ICU, the hypophosphatemia and hyperphosphatemia are common electrolyte disturbances. Recent studies have shown that ICU patients have a higher prevalence of hypophosphatemia and hyperphosphatemia [1,3,6,8,18,19]. It has varying degrees of impact on clinical outcomes, but due to its atypical clinical symptoms, it has not received much attention.…”

Section: Introductionmentioning

confidence: 99%

Is Monitoring for Phosphate a Necessary Measure in Critical Ill Patients ?

Chen

Luo

et al. 2020

Preprint

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Background: In recent years, some studies have shown that hyperphosphatemia and hypophosphatemia are associated with high mortality in intensive care unit (ICU) patients. Based on this, we speculated that the abnormalities of serum phosphate when patients enter the ICU had an adverse effect on the mortality of ICU patients and conducted our study.Methods: For our retrospective cohort study, we collected the data from a publicly accessible critical care database. We selected adult patients admitted to ICU with some inclusion criteria. And we extracted a large number of clinical variables. Using multivariate Cox regression and other statistical methods, we assessed the association between serum phosphate and primary endpoints.Results: Of 27131 eligible patients, the patients with hyperphosphatemia or hypophosphatemia had poorer clinical outcomes. After adjustment for potential confounders, there was no significant association between abnormalities phosphate and 28 or 90-day ICU mortality. Nevertheless, at the medical intensive care unit, hyperphosphatemia was associated with a 37% higher risk of 28-day mortality or a 25% higher risk of 90-day mortality.Conclusion: After adjustment for potential confounders, hypophosphatemia and hyperphosphatemia at ICU admission were not the independent risk factors of 28 or 90-day mortality for general ICU patients. However, hyperphosphatemia at admission increased the risk of 28 or 90-day mortality among patients admitted to the medical intensive care unit.

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Impact of Serum Phosphate in Mechanically Ventilated Patients With Severe Sepsis and Septic Shock

Cited by 48 publications

References 23 publications

Prognostic Value of Ionized Calcium Levels in Neonatal Sepsis

Prognostic Value of Ionized Calcium Levels in Neonatal Sepsis

The Effects of Serum Phosphate on 28-day Mortality in Patients Hospitalized in the Intensive Care Unit, Treated with Mechanical Ventilator Therapy and Treated with CRRT for Septic Shock-Induced Acute Kidney Injury

Is Monitoring for Phosphate a Necessary Measure in Critical Ill Patients ?

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Impact of Serum Phosphate in Mechanically Ventilated Patients With Severe Sepsis and Septic Shock

Cited by 48 publications

References 23 publications

Prognostic Value of Ionized Calcium Levels in Neonatal Sepsis

Prognostic Value of Ionized Calcium Levels in Neonatal Sepsis

The Effects of Serum Phosphate on 28-day Mortality in Patients Hospitalized in the Intensive Care Unit, Treated with Mechanical Ventilator Therapy and Treated with CRRT for Septic Shock-Induced Acute Kidney Injury

Is&nbsp;Monitoring for Phosphate&nbsp;a Necessary Measure in Critical Ill Patients ?

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Is Monitoring for Phosphate a Necessary Measure in Critical Ill Patients ?