2004
DOI: 10.1002/art.20006
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Impact of shared epitope genotype and ethnicity on erosive disease: A meta‐analysis of 3,240 rheumatoid arthritis patients

Abstract: Objective. The strongest known genetic association in rheumatoid arthritis (RA) is with HLA-DRB1 alleles that share a similar amino acid sequence, termed the shared epitope (SE). Although many studies have examined the association of the SE with disease severity, the results have been inconsistent, which may reflect the relatively small sample sizes or ethnic differences. The aim of this study was to assess the association of HLA-DRB1 SE alleles and genotype with the development of bony erosions in RA by meta-… Show more

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Cited by 134 publications
(108 citation statements)
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“…E 3 alleles that pool HLA-DRB1*0102 and *0404 alleles (QRRAA pattern at position 70-74) according to the classification suggested by Gao et al (5) appeared as predisposing alleles for structural severity in the present study. These results are consistent with the previously published results among northern European Cauca- soids, which showed an association between the HLA-DRB1*0404 allele and the structural severity of RA (13). The classification proposed by Tezenas du Montcel et al (6) allows the identification of protective alleles for RA severity, classified as S 3D alleles.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…E 3 alleles that pool HLA-DRB1*0102 and *0404 alleles (QRRAA pattern at position 70-74) according to the classification suggested by Gao et al (5) appeared as predisposing alleles for structural severity in the present study. These results are consistent with the previously published results among northern European Cauca- soids, which showed an association between the HLA-DRB1*0404 allele and the structural severity of RA (13). The classification proposed by Tezenas du Montcel et al (6) allows the identification of protective alleles for RA severity, classified as S 3D alleles.…”
Section: Discussionsupporting
confidence: 92%
“…The particular importance of the HLA-DRB1*0401 allele was recently emphasized in a meta-analysis that assessed the association of HLA-DRB1*SE alleles with bony erosions in RA. In that study, the HLA-DRB1*0401 allele appeared as the highest predisposing HLA-DRB1 allele for erosive RA among northern European Caucasoids (13). E 3 alleles that pool HLA-DRB1*0102 and *0404 alleles (QRRAA pattern at position 70-74) according to the classification suggested by Gao et al (5) appeared as predisposing alleles for structural severity in the present study.…”
Section: Discussionsupporting
confidence: 63%
“…Most DRB1 associations in common with RA have a sequence of amino acids at positions 70-74 of the third hypervariable region, known as the "shared epitope" (SE). Some studies have associated an increase in DRB1 frequency with an early onset of disease (4), radiologic erosions (5,6), and extraarticular manifestations (7,8); however, other studies have not supported these observations (9)(10)(11)(12). In addition, the DRB1 alleles associated with RA vary among ethnic groups.…”
mentioning
confidence: 99%
“…The most documented issue is the implication of the highly polymorphic HLA-DRB1 locus that can also be regarded as a biallelic locus through the so-called 'shared epitope' (SE) theory. [3][4][5][6][7] While the association between the SE and RA susceptibility is well established, the gene-dose effect is still controversial. 5,6,8,9 Furthermore, the effects of SE statistical interactions with age and sex on RA susceptibility are poorly documented.…”
mentioning
confidence: 99%