Impact of Shock-Induced Lipid Nanobubble Collapse on a Phospholipid Membrane

Sun, Dandan; Lin, Xubo; Zhang, Zuoheng; Gu, Ning

doi:10.1021/acs.jpcc.6b04086

Cited by 22 publications

(27 citation statements)

References 47 publications

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“…To address this problem, we theorize that the addition of a cavitation bubble between the shockwave and the model cell membrane can alter the shockwave front, allowing low-velocity shockwaves to specifically damage the intended target while causing little to no collateral damage. Previous works have focused on using shockwaves to cause damage, and cavitation bubbles to help a shockwave penetrate a lipid bilayer before [Santo and Berkowitz, 2015, 2014; Sliozberg and Chantawansri, 2014; Sun et al , 2016; Choubey et al , 2011], but here we extend that to focus specifically on the effect of shockwave velocity, bubble size, and orientation on damage to spherical model cells.…”

Section: Introductionmentioning

confidence: 99%

Effects of nanobubble collapse on cell membrane integrity

Becton

Averett

Wang

2017

J. Micromech. Mol. Phys.

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Recent studies have shown that ultrasound is used to open drug-carrying liposomes to release their payloads; however, a shockwave energetic enough to rupture lipid membranes can cause collateral damage to surrounding cells. Similarly, a destructive shockwave, which may be used to rupture a cell membrane in order to lyse the cell (e.g., as in cancer treatments) may also impair or destroy nearby healthy tissue. To address this problem, we use dissipative particle dynamic (DPD) simulation to investigate the addition of a cavitation bubble between the shockwave and the model cell membrane to alter the shockwave front, allowing low-velocity shockwaves to specifically damage an intended target. We focus specifically on a spherical lipid bilayer model, and note the effect of shockwave velocity, bubble size, and orientation on the damage to the model cell. We show that a cavitation bubble greatly decreases the necessary shockwave velocity required to damage the lipid bilayer and rupture the model cell. The cavitation bubble focuses the kinetic energy of the shockwave front into a smaller area, inducing penetration at the edge of the model cell. With this work, we provide a comprehensive approach to the intricacies of model cell destruction via shockwave impact, and hope to offer a guideline for initiating targeted cellular destruction using induced cavitation bubbles and low-velocity shockwaves.

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Section: Introductionmentioning

confidence: 99%

Effects of nanobubble collapse on cell membrane integrity

Becton

Averett

Wang

2017

J. Micromech. Mol. Phys.

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“…Hence, lipid nanobubbles may have excellent biocompatibility. On the other hand, lipid nanobubbles can fuse with cell membrane under a certain intensity of ultrasound [11] . Thus, cell membrane can incorporate lipids from lipid nanobubbles [11] and encapsulated gas molecules can re-distribute into the hydrophobic region of cell membrane [12] .…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, lipid nanobubbles can fuse with cell membrane under a certain intensity of ultrasound [11] . Thus, cell membrane can incorporate lipids from lipid nanobubbles [11] and encapsulated gas molecules can re-distribute into the hydrophobic region of cell membrane [12] . The former will change the local membrane components, while the latter can decouple the two membrane leaflets and modify membrane structural properties.…”

Section: Introductionmentioning

confidence: 99%

“…Molecular dynamics (MD) simulations provide a powerful tool to investigate the interactions between biomolecules at atomic/near-atomic resolution [13] . Many computational efforts have been made to study the stability and dynamics of lipid nanobubbles as well as their interactions with model cell membrane [11,[14][15][16] . Especially, coarse-grained models (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Developing Martini Coarse-Grained Nitrogen Gas Model for Lipid Nanobubble Simulations

Tian¹,

Lin

2021

Preprint

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<p>By integrating the advantages of lipids’ biocompatibility and nanobubbles’ potent physicochemical properties, lipid nanobubbles show a great potential in ultrasound molecular imaging and biocompatible drug/gene delivery. However, under the interactions of the ultrasound, lipid nanobubbles may fuse with the cell membrane, changing the local membrane component and re-distributing encapsulated gas molecules into the hydrophobic region of the cell membrane, which may greatly affect the dynamics of certain membrane proteins and thus functions of cells. Although molecular dynamics simulation provides a useful computational tool to reveal the related molecular mechanisms, the lack of coarse-grained gas model greatly restricts this purpose. In the current work, we developed a Martini-compatible coarse-grained gas model based on the results of previous experiments and atomistic simulations, which could be used for lipid nanobubble simulations with complicated lipid components. By comparing the results of well-designed lipid nanobubble, lipid bi-monolayer and lipid bilayer simulations, we further revealed the role of membrane curvature and interleaflet coupling in the liquid-liquid phase separation of lipid membranes. It is worth mention that our developed coarse-grained nitrogen gas model can also be used for other gas-water interface systems such as pulmonary surfactant, which may overcome the possible artefacts arising from the usage of vacuum for gas phase. </p>

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“…Molecular dynamics (MD) simulations are well suited for studying membrane dynamics in the atomistic and molecular scales [6], [7]. Considerable research has been made to use MD simulations to ascertain the structural changes of lipid bilayer membranes subjected to shock waves and the effect of shock waves on membrane permeability [8–12]. Koshiyama et al[13] modeled shock waves in silico on DPPC-containing lipid bilayer models.…”

Section: Introductionmentioning

confidence: 99%

Effect of pressure profile of shock waves on lipid membrane deformation

et al. 2019

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Use of shock waves to temporarily increase the permeability of the cell membrane is a promising approach in drug delivery and gene therapy to allow the translocation of macromolecules and small polar molecules into the cytoplasm. Our understanding of how the characteristics of the pressure profile of shock waves, such as peak pressure and pulse duration, influences membrane properties is limited. Here we study the response of lipid bilayer membranes to shock pulses with different pressure profiles using atomistic molecular dynamics simulations. From our simulation results, we find that the transient deformation/disordering of the membrane depends on both the magnitude and the pulse duration of the pressure profile of the shock pulse. For a low pressure impulse, peak pressure has a dominant effect on membrane structural changes, while for the high pressure impulse, we find that there exists an optimal pulse duration at which membrane deformation/disordering is maximized.

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Impact of Shock-Induced Lipid Nanobubble Collapse on a Phospholipid Membrane

Cited by 22 publications

References 47 publications

Effects of nanobubble collapse on cell membrane integrity

Effects of nanobubble collapse on cell membrane integrity

Developing Martini Coarse-Grained Nitrogen Gas Model for Lipid Nanobubble Simulations

Effect of pressure profile of shock waves on lipid membrane deformation

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