Impact of Short-Term Exposure to Below Recommended PM10 Pollution Levels on Asthma Exacerbations

Betancourt, Adriana Isabel; Zapatero, Antonio; Pola-Bibian, B; Domínguez‐Ortega, Javier

doi:10.18176/jiaci.0663

Cited by 2 publications

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“…Illustratively, research conducted by Chuansha Wu et al underscores the pronounced risk of childhood asthma associated with early-life exposure to PM10 in a cohort of children aged 3 to 6 years across several Chinese cities ( 43 ). Additional studies, including one by Betancourt and a Korean study focusing on PM10 exposure during pregnancy linked to asthma in offspring among 1,572 mother-infant pairs ( 44 , 45 ), further validate PM10’s detrimental effects. A study involving a Southern Taiwanese adult population also found that individuals exposed to elevated PM10 levels experienced more severe asthma symptoms ( 46 ).…”

Section: Discussionmentioning

confidence: 91%

Causal association between air pollution and allergic rhinitis, asthma: a Mendelian randomization study

Zhong,

Li,

Yang

et al. 2024

Front. Public Health

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BackgroundsObservational studies suggest that air pollutants, including particulate matter and nitrogen compounds, could elevate asthma and allergic rhinitis health risks. Nevertheless, the exact nature of the causal relationship between air pollution and asthma and allergic rhinitis remains unknown. This study utilizes the Mendelian randomization (MR) technique to explore the potential causal links between air pollution components (PM2.5, PM2.5–10, PM10, NO₂, and nitrogen dioxide) and the incidence of allergic rhinitis and asthma.MethodsA MR study utilized summary statistics from GWAS that are publicly accessible. The inverse variance weighting (IVW) approach served as the foundational analysis technique. To ensure robustness, supplementary methodologies such as the weighted median, MR-Egger regression, simple mode, and weighted model were also applied. Heterogeneity was evaluated using Cochran’s Q test, and the presence of pleiotropy was determined through MR-Egger regression. The MR-PRESSO test was employed for outlier detection, and the analysis’s sensitivity was scrutinized via a leave-one-out strategy.ResultsThe IVW technique showed a strong correlation between PM10 and asthma (OR = 0.625, 95% CI = 0.396–0.988, p = 0.044). No significant associations were found between asthma and other air pollutants such as PM2.5, PM2.5–10, NO₂, or nitrogen dioxide. Similarly, allergic rhinitis showed no causal relationships with any studied air pollution metrics. Pleiotropy was absent in the findings. Sensitivity analyses, employing the leave-one-out method, confirmed the stability of these results, unaffected by individual single nucleotide polymorphisms (SNPs).ConclusionThis Mendelian randomization study establishes a causal link between PM10 exposure and asthma, suggesting that interventions to reduce air pollution may decelerate the adverse progression of asthma.

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Section: Discussionmentioning

confidence: 91%

Causal association between air pollution and allergic rhinitis, asthma: a Mendelian randomization study

Zhong,

Li,

Yang

et al. 2024

Front. Public Health

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“…It is well established that TRAP pollutants worsen the evolution of asthmatic patients. For three decades, numerous studies have verified the close relationship between emergency care and hospitalizations due to increased concentrations of air pollutants, even with concentrations lower than those recommended by environmental agencies 21–24 . In most studies, only the effects on severe asthma have been evaluated; mild and moderate asthma, which represent 90% of cases of this disease, have been little studied but are also affected by air pollution 25 .…”

Section: Discussionmentioning

confidence: 99%

“…For three decades, numerous studies have verified the close relationship between emergency care and hospitalizations due to increased concentrations of air pollutants, even with concentrations lower than those recommended by environmental agencies. [21][22][23][24] In most studies, only the effects on severe asthma have been evaluated; mild and moderate asthma, which represent 90% of cases of this disease, have been little studied but are also affected by air pollution. 25 Likewise, the monitoring of patients throughout the year dilutes the seasonal effect of pollen as a cofactor involved in the evolution of patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical impact and immunological alterations in asthmatic patients allergic to grass pollen subjected to high urban pollution in Madrid

Brito

Alfaya

Amo-Salas

et al. 2021

Clin Experimental Allergy

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Background:The prevalence of asthma has increased in recent decades. Among the reasons for this increase is environmental pollution. Pollutants cause bronchial inflammation and introduce modifications in the pollen, making it more allergenic.Objective: Assess symptoms and medication requirements of asthmatic patients with grass allergies in Madrid (high urban pollution) and Ciudad Real (low pollution), and simultaneously evaluate the in vitro effects that pollen collected in both areas has on the immune cells of patients.Methods: During two pollen seasons, patients from both cities were included. The patients recorded their symptoms and the asthma medication they took daily. In both cities, pollen data, pollutants and meteorological variables were evaluated. The response to different cell populations from patients in both areas were analysed after "in vitro" stimulation with pollen from both cities. Results:The symptoms and medication use of the patients in Madrid was 29.94% higher. The NO 2 concentration in Madrid was triple that of Ciudad Real (33.4 vs. 9.1 µg/m 3 of air). All other pollutants had very similar concentrations during the study period. Pollen from the high pollution area caused a significant enhancement of T-CD8+ and NK cells proliferation compared with pollen of low pollution area, independently of the patient's origin. Conclusion:Asthmatic patients from Madrid have a worse clinical evolution than those from Ciudad Real because of higher levels of urban pollution, and this could be driven by the higher capacity of pollen of Madrid to activate T-CD8+ and NK cells.

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Impact of Short-Term Exposure to Below Recommended PM10 Pollution Levels on Asthma Exacerbations

Cited by 2 publications

References 0 publications

Causal association between air pollution and allergic rhinitis, asthma: a Mendelian randomization study

Causal association between air pollution and allergic rhinitis, asthma: a Mendelian randomization study

Clinical impact and immunological alterations in asthmatic patients allergic to grass pollen subjected to high urban pollution in Madrid

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