Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

Perin, P.M.; Maluf, Mariângela; Czeresnia, Carlos Eduardo; Januário, Daniela Aparecida Nicolosi Foltran; Saldiva, Paulo Hilário Nascimento

doi:10.1007/s10815-010-9419-2

Cited by 81 publications

(49 citation statements)

References 37 publications

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“…Preimplantation hypothesis proposes that in some circumstances there are more favourable development or survival of X or Y bearing sperm or survival of male or female embryos 23–25. In a previous study of our group we have shown that exposure to PM during the preconception period are associated to early pregnancy loss in women undergoing in vitro fertilisation26 and thus there is also another possibility to explain the changes in sex ratio by sex specific increases in intrauterine death or stillbirth.…”

Section: Discussionmentioning

confidence: 88%

Follow-up of the air pollution and the human male-to-female ratio analysis in São Paulo, Brazil: a times series study

et al. 2013

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ObjectivesIn order to assess if ambient air pollution in urban areas could be related to alterations in male/female ratio this study objectives to evaluate changes in ambient particulate matter (PM10) concentrations after implementation of pollution control programmes in São Paulo city and the secondary sex ratio (SRR).Design and methodsA time series study was conducted. São Paulo’s districts were stratified according to the PM10 concentrations levels and were used as a marker of overall air pollution. The male ratio was chosen to represent the secondary sex ratio (SSR=total male birth/total births). The SSR data from each area was analysed according to the time variation and PM10 concentration areas using descriptive statistics. The strength association between annual average of PM10 concentration and SSR was performed through exponential regression, and it was adopted as a statistical significance level of p<0.05.ResultsThe exponential regression showed a negative and significant association between PM10 and SSR. SSR varied from 51.4% to 50.7% in São Paulo in the analysed period (2000–2007). Considering the PM10 average concentration in São Paulo city of 44.72 μg/m3 in the study period, the SSR decline reached almost 4.37%, equivalent to 30 934 less male births.ConclusionsAmbient levels of PM10 are negatively associated with changes in the SSR. Therefore, we can speculate that higher levels of particulate pollution could be related to increased rates of female births.

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Section: Discussionmentioning

confidence: 88%

Follow-up of the air pollution and the human male-to-female ratio analysis in São Paulo, Brazil: a times series study

et al. 2013

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“…), or on the rates of embryo implantation and pregnancy. On the other hand, they found a statistically significant increase of 5% in the risk of early pregnancy loss per unit increase in follicular phase PM10 exposure, leading to an increased rate of early miscarriages among women exposed to the highest quartile of concentrations of PM10 [35]. In another study on 531 pregnant women, the same authors found that women exposed to high concentrations of large particulate matter (PM10) during the follicular phase of the ovarian cycle had a two-fold increased rate of early miscarriages, no matter if the conception was natural or the result of IVF [36].…”

Section: Resultsmentioning

confidence: 97%

“…Altogether, the data from the 3 available human studies about air quality and IVF results provide a weak level of evidence because they consist in retrospective studies, with long observation periods (7 [34] to 10 years [35,36] during which effectiveness of IVF procedures may have improved), with approximated exposures based either on estimated levels from national models of air quality [34] or on average daily exposure of an entire city [35,36], without accounting for the exact home address [35,36] or its distance from the nearest monitoring station [34] or with residual confounding from tobacco exposure [34]. Furthermore, the results of these studies are discordant regarding PM10, the only air pollutant commonly evaluated by these studies.…”

Section: Resultsmentioning

confidence: 99%

Does air pollution play a role in infertility?: a systematic review

et al. 2017

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Background: Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxygen species inducers, and through the formation of DNA adducts and/or epigenetic modifications. We conducted a systematic review of the published literature on the impact of air pollution on reproductive function. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included (1) ovary or follicle or oocyte or testis or testicular or sperm or spermatozoa or fertility or infertility and (2) air quality or O 3 or NO 2 or PM2.5 or diesel or SO 2 or traffic or PM10 or air pollution or air pollutants. The literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We have included the human and animal studies corresponding to the search terms and published in English. We have excluded articles whose results did not concern fertility or gamete function and those focused on cancer or allergy. We have also excluded genetic, auto-immune or iatrogenic causes of reduced reproduction function from our analysis. Finally, we have excluded animal data that does not concern mammals and studies based on results from in vitro culture. Data have been grouped according to the studied pollutants in order to synthetize their impact on fertility and the molecular pathways involved.

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“…Couple-based fecundability was assessed in Teplice, where pregnancy in the first month of unprotected intercourse was less likely when couples were exposed to higher levels of nitrogen dioxide (NO 2 ) and PM 2.5 (9). NO 2 was associated with lower live birth rates and PM 2.5 with decreased conception rates after in vitro fertilization (IVF),(10) whereas miscarriage rates appeared higher in couples exposed to the highest quartile of PM exposure prior to IVF or embryo transfer(11). In mice, traffic-related pollutant exposures decreased fertility with effects demonstrated for both males and females as well as mating pairs(12;13) and reductions in placental and fetal weight were observed among mice housed near roadways in Brazil(14).…”

Section: 0 Introductionmentioning

confidence: 99%

Proximity to major roadways and prospectively-measured time-to-pregnancy and infertility

Mendola

Sundaram

Louis

et al. 2017

Science of The Total Environment

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We aimed to study the potential impact of proximity to major roadways on time-to-pregnancy and infertility in couples attempting pregnancy in the Longitudinal Investigation of Fertility and Environment (LIFE) study (2005-2009), a population-based, prospective cohort study. Couples attempting pregnancy (n=500) were enrolled and followed prospectively until pregnancy or 12 months of trying and 393 couples (78%) had complete data and full follow-up. Time-to-pregnancy was based on a standard protocol using fertility monitors, tracking estrone-3-glucuonide and luteinizing hormone, and pregnancy test kits to detect human chorionic gonadotropin (hCG). The fecundability odds ratio (FOR) and 95% confidence interval (CI) were estimated using proportional odds models. Infertility was defined as 12 months of trying to conceive without an hCG pregnancy and the relative risk (RR) and 95% CI were estimated with log-binomial regression. Final models were adjusted for age, parity, study site, and salivary alpha-amylase, a stress marker. Infertile couples (53/393; 14%) tended to live closer to major roadways on average than fertile couples (689 m vs. 843 m, respectively) but the difference was not statistically significant. The likelihood of pregnancy was increased 3% for every 200 meters further away the couples residence was from a major roadway (FOR=1.03; CI=1.01-1.06). Infertility also appeared elevated at moderate distances compared to 1000 meters or greater, but estimates lacked precision. Our findings suggest that proximity to major roadways may be related to reductions in fecundity. Prospective data from larger populations is warranted to corroborate these findings.

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Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

Cited by 81 publications

References 37 publications

Follow-up of the air pollution and the human male-to-female ratio analysis in São Paulo, Brazil: a times series study

Follow-up of the air pollution and the human male-to-female ratio analysis in São Paulo, Brazil: a times series study

Does air pollution play a role in infertility?: a systematic review

Proximity to major roadways and prospectively-measured time-to-pregnancy and infertility

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