Impact of sildenafil-containing ointment on wound healing in healthy and experimental diabetic rats

Dayyih, Wael Abu; Rayyan, Walid Abu; Al-Matubsi, Hisham Y.

doi:10.1007/s00592-020-01562-0

Cited by 7 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Streptozotocin-induced diabetic Wistar rats with incisions of the dorsal backs 5% sildenafil-containing ointments Significantly decreased wound area in both non-diabetic and diabetic rats, especially during the first stages of wound healing [116].…”

Section: Population Dosage Resultsmentioning

confidence: 91%

Exploring the Multifaceted Potential of Sildenafil in Medicine

Pușcașu,

Zanfirescu,

Negreș

et al. 2023

Medicina

View full text Add to dashboard Cite

Phosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive roles of PDE5, sildenafil might be useful in other pathologies. This review aims to comprehensively explore sildenafil’s therapeutic potential across medicine, addressing a gap in the current literature. Recognising sildenafil’s broader potential may unveil new treatment avenues, optimising existing approaches and broadening its clinical application.

show abstract

Section: Population Dosage Resultsmentioning

confidence: 91%

Exploring the Multifaceted Potential of Sildenafil in Medicine

Pușcașu,

Zanfirescu,

Negreș

et al. 2023

Medicina

View full text Add to dashboard Cite

show abstract

“…In a study included 52 severely burned patients enteral nutrition was applied to feed patients: 28 patients were given enteral nutrition within 3 days of injury and 24 patients received enteral nutrition after three days. Results showed that the earlier use of the enteral nutrition improved prealbumin 20,21 .…”

Section: Nutritionmentioning

confidence: 97%

Clinical Nutrition in Diabetes Mellitus with 3rd Degree Burns and Foot Ulcer as Complicated

Dayyih

Zakareia

Tamimi

et al. 2021

Asian Journal of Pharmaceutical Research and Health Care

Self Cite

View full text Add to dashboard Cite

Burns are complex injuries that lead to hyperglycemia as a stress response. Diabetes Mellitus (DM) is a hormonal and metabolic disorder categorized by impaired insulin secretion and yielding to elevate plasma glucose levels and therefore complicates the therapy of burns, it is also developed via uncontrolled stress reaction to the burn. Also, DM will impact on nutrition and lifestyle of burn patients. This review provides pathophysiology, difficulties and managements of burns related to the patients with DM to offer evidence-based care to seriously ill people. Performing a treatment for diabetic burn patient is difficult for healthcare professionals. Traumatic burn in non-diabetic people may develop stress-induced hyperglycemia which ends up with DM due to endocrine complications from their injury. The higher risk for burn injuries is found in pre-existing DM. Special medical plan should be employed to control burns. Additionally, treatments for present burn must be reformed to avoid diabetes mellitus, management of glucose level, and help healing process in diabetic foot ulcer.

show abstract

“…In a more recent study of wound healing, topically used sildenafil was associated with a significant reduction in wound area and an increase in tensile strength when compared with treatment with oral sildenafil, negative (vehicle) or positive (burn ointment) controls in both diabetic and non‐diabetic rats. 88 Moreover, sildenafil‐containing ointment promoted greater collagen synthesis and vascularisation in comparison with oral sildenafil‐treated rats and controls. Nonetheless, the topical PDE5i‐facilitated wound healing was much more pronounced in the non‐diabetic than in the diabetic rats.…”

Section: Pde5i and Wound Healingmentioning

confidence: 98%

“…Moreover, sildenafil‐containing ointment promoted greater collagen synthesis and vascularisation in comparison with oral sildenafil‐treated rats and controls. Nonetheless, the topical PDE5i‐facilitated wound healing was much more pronounced in the non‐diabetic than in the diabetic rats 88 . Studies looking at the effects of PDE5 inhibition on wound healing in humans are currently lacking.…”

Section: Pde5i and Wound Healingmentioning

confidence: 99%

See 1 more Smart Citation

The efficacy of PDE5 inhibitors in diabetic patients

Święcicka

2022

Andrology

View full text Add to dashboard Cite

Background: Phosphodiesterase 5 inhibitors (PDE5i), since their introduction in the late 1990s, have proven their efficacy in treating several conditions, predominantly pulmonary hypertension and erectile dysfunction where they remain the first-line therapeutic option. However, in the recent years, growing evidence from both animal and human studies has emerged to suggest the additional benefits of PDE5i in cardiovascular and metabolic disorders. This is of specific interest to the diabetes population where prevalent cardiovascular disease and metabolic dysregulation significantly contribute to the increased morbidity and mortality. Objectives:To examine the available data on the non-standard, pleiotropic effects of PDE5i in patients with diabetes mellitus. Materials and methods:The review of the published background research, preclinical studies and clinical trials. Results:In human studies, PDE5 inhibition appeared to be associated with reduced cardiovascular mortality and overall improved clinical outcomes in those with established cardiovascular disease. PDE5i were also consistently found to reduce albuminuria in subjects with diabetic nephropathy. Furthermore, animal data suggest a plausible effect of this group of medication on sensory function and neuropathic symptoms in diabetic neuropathy as well as improved wound healing. A decrease in insulin resistance and augmentation of beta cell function seen in preclinical studies has not been consistently demonstrated in human trials. Discussion and conclusion:In animal models, PDE5 inhibition appears to decrease oxidative stress and reduce some of the micro-and macrovascular complications associated with diabetes. However, data from human trials are limited and largely inconsistent, highlighting the need for adequately powered, randomised-controlled trials in diabetic cohorts in order to fully assess the benefits of PDE5i in this group of patients.

show abstract

Impact of sildenafil-containing ointment on wound healing in healthy and experimental diabetic rats

Cited by 7 publications

References 33 publications

Exploring the Multifaceted Potential of Sildenafil in Medicine

Exploring the Multifaceted Potential of Sildenafil in Medicine

Clinical Nutrition in Diabetes Mellitus with 3rd Degree Burns and Foot Ulcer as Complicated

The efficacy of PDE5 inhibitors in diabetic patients

Contact Info

Product

Resources

About