Impact of simulated biological aging on physicochemical and biocompatibility properties of cyclic olefin copolymers

Bernard, Mélisande; Jubeli, Emile; Bakar, Joudi; Saunier, Johanna; Yagoubi, Najet

doi:10.1016/j.msec.2018.12.032

Cited by 13 publications

(3 citation statements)

References 27 publications

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“…During incubation, the degradation rate of PLLA and PLLA/COC10 nanocomposites were increased over time and the rate of degradation was higher for PLLA alone. The rate of degradation for PLLA was observed at 93% after 7 days of incubation, reaching 30% after 48 days [51,52]. Moreover, upon increasing the concentration of HA, the degradation rate of PLLA/nHA was decreased.…”

Section: Degradation Analysismentioning

confidence: 95%

Comparative Study of Crystallization, Mechanical Properties, and In Vitro Cytotoxicity of Nanocomposites at Low Filler Loadings of Hydroxyapatite for Bone-Tissue Engineering Based on Poly(l-lactic acid)/Cyclo Olefin Copolymer

Nazir

Iqbal

2021

Polymers

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A poly(l-lactic acid)/nanohydroxyapatite (PLLA/nHA) scaffold works as a bioactive, osteoconductive scaffold for bone-tissue engineering, but its low degradation rate limits embedded HA in PLLA to efficiently interact with body fluids. In this work, nano-hydroxyapatite (nHA) was added in lower filler loadings (1, 5, 10, and 20 wt%) in a poly(l-lactic acid)/cyclo olefin copolymer10 wt% (PLLA/COC10) blend to obtain novel poly(l-lactic acid)/cyclo olefin copolymer/nanohydroxyapatite (PLLA/COC10-nHA) scaffolds for bone-tissue regeneration and repair. Furthermore, the structure-activity relationship of PLLA/COC10-nHA (ternary system) nanocomposites in comparison with PLLA/nHA (binary system) nanocomposites was systematically studied. Nanocomposites were evaluated for structural (morphology, crystallization), thermomechanical properties, antibacterial potential, and cytocompatibility for bone-tissue engineering applications. Scanning electron microscope images revealed that PLLA/COC10-nHA had uniform morphology and dispersion of nanoparticles up to 10% of HA, and the overall nHA dispersion in matrix was better in PLLA/COC10-nHA as compared to PLLA/nHA. Fourier transformation infrared spectroscopy (FTIR), powder X-ray diffraction (XRD), and differential scanning calorimetry (DSC) studies confirmed miscibility and transformation of the α-crystal form of PLLA to the ά-crystal form by the addition of nHA in all nanocomposites. The degree of crystallinity (%) in the case of PLLA/COC10-nHA 10 wt% was 114% higher than pure PLLA/COC10 and 128% higher than pristine PLLA, indicating COC and nHA are acting as nucleating agents in the PLLA/COC10-nHA nanocomposites, causing an increase in the degree of crystallinity (%). Moreover, PLLA/COC10-nHA exhibited 140 to 240% (1–20 wt% HA) enhanced mechanical properties in terms of ductility as compared to PLLA/nHA. Antibacterial activity results showed that 10 wt% HA in PLLA/COC10-nHA showed substantial activity against P. aeruginosa, S. aureus, and L. monocytogenes. In vitro cytocompatibility of PLLA/COC10 and PLLA nanocomposites with nHA osteoprogenitor cells (MC3T3-E1) and bone mesenchymal stem cells (BMSC) was evaluated. Both cell lines showed two- to three-fold enhancement in cell viability and 10- to 30-fold in proliferation upon culture on PLLA/COC10-nHA as compared to PLLA/nHA composites. It was observed that the ternary system PLLA/COC10-nHA had good dispersion and interfacial interaction resulting in improved thermomechanical and enhanced osteoconductive properties as compared to PLLA/nHA.

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Section: Degradation Analysismentioning

confidence: 95%

Comparative Study of Crystallization, Mechanical Properties, and In Vitro Cytotoxicity of Nanocomposites at Low Filler Loadings of Hydroxyapatite for Bone-Tissue Engineering Based on Poly(l-lactic acid)/Cyclo Olefin Copolymer

Nazir

Iqbal

2021

Polymers

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“…Cyclic olefin copolymers (COCs) are amorphous transparent material prepared by metallocene polymerization with norbornene or its derivatives and ethylene. [1][2][3][4][5] Compared with traditional transparency plastics such as polycarbonate (PC) and polymethyl methacrylate (PMMA), COC resin has been widely used in high-end lenses, medical equipment, [6] and pharmaceutical packaging [7] due to its high water vapor barrier rate, [8,9] good chemical resistance, [10] and high biocompatibility. [11] But, due to the high requirements for materials in the optical field and pharmaceutical field, recycled COC resin is not permitted to employ again.…”

Section: Introductionmentioning

confidence: 99%

Preparation the composite with high toughness and strength by recycled cyclic olefin copolymer

Ming

Liu

et al. 2022

Polymer Engineering & Sci

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At present, it is of great significance to develop an effective method of recycling cyclic olefin copolymers (rCOC) due to its increasing application. But, its poor toughness is still an important difficulty to limit its effective recycling. In this article, we introduced PA6 into the POE-g-MAH/rCOC composites. Because of the good compatibility of POE-g-MAH between PA6 and rCOC, it just led to an overall improvement in mechanical properties of PA6/POE-g-MAH/rCOC (45/15/40) composites. Its tensile strength reached 42.3 MPa, which was more than 41.9% compared with that of POE-g-MAH/rCOC composites. Its notched impact strength was 11.7 kJ/m 2 , which was higher than 875.0% compared with rCOC. Furthermore, the component of PA6 was wrapped by nonpolar rCOC and POE-g-MAH, resulting in a low water absorption rate (1.0%). So, the strength of the composites only dropped a little after water adsorption. In summary, the addition of PA6 helped the composites effectively utilize the toughness of POE-g-MAH. Thus, we developed an easy method to recycle rCOC and prepare the responding composites with high strength and toughness.compatibility, PA6, POE-g-MAH, recycled cycloolefin copolymer, toughening | INTRODUCTIONCyclic olefin copolymers (COCs) are amorphous transparent material prepared by metallocene polymerization with norbornene or its derivatives and ethylene. [1][2][3][4][5] Compared with traditional transparency plastics such as polycarbonate (PC) and polymethyl methacrylate (PMMA), COC resin has been widely used in high-end lenses, medical equipment, [6] and pharmaceutical packaging [7] due to its high water vapor barrier rate, [8,9] good chemical resistance, [10] and high biocompatibility. [11] But, due to the high requirements for materials in the optical field and pharmaceutical field, recycled COC resin is not permitted to employ again. Thus, the recycling of this stable COC resin becomes more and more urgent. However, the poor toughness of rCOC has greatly limited

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“…Gradient devices, for organ-on-chip applications, made of PDMS can be widely found in the literature [1] [2]. Gradient devices made of thermoplastic materials [3] can be also found in literature [4], but most of them include micropillars. This inert hydrogel alteration can create a physical barrier between the central chamber and side channels, hindering the gradient formation and cell interactions.…”

Section: Introductionmentioning

confidence: 99%

Novel Fabrication Technique to Confine Hydrogels with Different Patterns inside Microfluidic Devices without Pillars

Rodrigo¹,

Bayona²,

Pérez³

et al. 2022

Jorn. jovenes investig. I3A

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Impact of simulated biological aging on physicochemical and biocompatibility properties of cyclic olefin copolymers

Cited by 13 publications

References 27 publications

Comparative Study of Crystallization, Mechanical Properties, and In Vitro Cytotoxicity of Nanocomposites at Low Filler Loadings of Hydroxyapatite for Bone-Tissue Engineering Based on Poly(l-lactic acid)/Cyclo Olefin Copolymer

Comparative Study of Crystallization, Mechanical Properties, and In Vitro Cytotoxicity of Nanocomposites at Low Filler Loadings of Hydroxyapatite for Bone-Tissue Engineering Based on Poly(l-lactic acid)/Cyclo Olefin Copolymer

Preparation the composite with high toughness and strength by recycled cyclic olefin copolymer

Novel Fabrication Technique to Confine Hydrogels with Different Patterns inside Microfluidic Devices without Pillars

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