Impact of Single Nucleotide Polymorphism in IL-4, IL-4R Genes and Systemic Concentration of IL-4 on the Incidence of Glioma in Iraqi Patients

Shamran, Haidar A.; Hamza, Subah J.; Yaseen, Nahi Y.; Al-Juboory, Ahmad A.; Taub, Dennis D.; Price, Robert L.; Nagarkatti, Mitzi; Singh, Udai P.

doi:10.7150/ijms.9412

Cited by 16 publications

(15 citation statements)

References 43 publications

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“…Of these 31 studies, 24 articles assessed the relationship between blood‐based inflammatory cytokines and glioma risk. Table presents the characteristics and quality evaluation of these 24 included studies.…”

Section: Resultsmentioning

confidence: 99%

“…Of these 24 studies, 10 examined IL‐6, five examined IL‐8, four examined interleukin‐17 (IL‐17), nine examined TNF‐ α , three examined transforming growth factor‐ β (TGF‐ β ), two examined CRP, three examined interleukin‐4 (IL‐4), five examined IL‐10, three examined interleukin‐12 (IL‐12), two examined interleukin‐23 (IL‐23), and four examined monocyte chemotactic protein‐1 (MCP‐1) . Among these 24 studies, serum samples from patients with glioma were collected in 22, and plasma samples were collected in the other two . Most of these studies used an enzyme‐linked immunosorbent assay (ELISA) to detect the concentrations of inflammatory cytokines, and only a few studies used other methods, such as bead array technology, fluorescence microsphere detection, xMAP, and radioimmunoassays .…”

Section: Resultsmentioning

confidence: 99%

“…A total of 1950 glioma patients and 1160 controls were included in these studies. Of these 24 studies, 10 examined IL-6, 9,10,24,29,33,[36][37][38][39]43 five examined IL-8, 28,30,36,37,44 four examined interleukin-17 (IL-17), 30,33,39,40 nine examined TNF-α, 9,24,27,29,33,36,37,41,45 three examined transforming growth factor-β (TGF-β), 25,26,39 two examined CRP, 9,34 three examined interleukin-4 (IL-4), 33,35,37 five examined IL-10, 31,33,36,37,42 three examined interleukin-12 (IL-12), 33,37,44 two examined interleukin-23 (IL-23), 39,40 and four examined monocyte chemotactic protein-1 (MCP-1). 24,28,29,32 Among these 24 studies, serum samples from patients with glioma were collected in 22,9,…”

Section: Characteristics and Quality Evaluation Of The Included Stumentioning

confidence: 99%

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Relationship between circulating inflammatory factors and glioma risk and prognosis: A meta‐analysis

et al. 2019

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Background Inflammatory factors have been considered a significant factor contributing to the development and progression of glioma. However, the relationship between circulating inflammatory factors and glioma risk as well as their prognostic values in glioma patients is still inconclusive. Here, we performed a meta‐analysis to address this issue. Methods Relevant articles were identified through PubMed, EMBASE, the Cochrane Library, Web of Science, Wanfang database, and China National Knowledge Infrastructure (CNKI) from inception to February 2019. The weighted mean differences (WMDs) or standard mean differences (SMDs) with 95% confidence intervals (CIs) were used to describe the predictive ability of the levels of circulating inflammatory factors on glioma risk. To evaluate the prognostic values of the circulating inflammatory factors in glioma, hazard ratios (HRs) with 95% CIs were used. Results Thirty‐one studies comprising 2587 patients were included. The overall analysis showed that increased circulating interleukin‐6 (IL‐6) [SMD 0.81 (95% CI: 0.21‐1.40; P = .008)], interleukin‐8 (IL‐8) [SMD 1.01 (95% CI: 0.17‐1.84; P = .018)], interleukin‐17 (IL‐17) [SMD 1.12 (95% CI: 0.26‐1.98; P = .011)], tumor necrosis factor‐α (TNF‐α) [SMD 1.80 (95% CI: 1.03‐2.56; P = .000)], transforming growth factor‐β (TGF‐β) [SMD 10.55 (95% CI: 5.59‐15.51; P = .000)], and C‐reactive protein (CRP) [SMD 0.95 (95% CI: 0.75‐1.15; P = .000)] levels were significantly associated with glioma risk. On the other hand, our results showed that circulating IL‐6 [HR 1.10 (95% CI: 1.05‐1.16; P = .000)] and CRP [HR 2.02 (95% CI: 1.52‐2.68; P = .000)] levels were highly correlated with a poor overall survival (OS) rate in glioma patients. Conclusion Our results indicate that increased circulating IL‐6, IL‐8, IL‐17, TNF‐α, TGF‐β, and CRP levels are significantly associated with increased glioma risk. Moreover, our meta‐analysis suggests that circulating IL‐6 and CRP may serve as powerful biomarkers for a poor prognosis in glioma patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Characteristics and Quality Evaluation Of The Included Stumentioning

confidence: 99%

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Relationship between circulating inflammatory factors and glioma risk and prognosis: A meta‐analysis

et al. 2019

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“…Several mechanisms could explain our findings. The T allele of IL‐4 rs2243250 polymorphism can increase binding of nuclear transcription factors to the promoter region of the IL‐4 gene and activate the transcription of genes involved in the pathogenesis of HT (Shamran et al, ). Further, Mazziotti et al showed a significant increase in CD4 + IL4 + cells in euthyroid patients with isolated HT (Mazziotti et al, ).…”

Section: Discussionmentioning

confidence: 99%

Association of cytokine Th2 gene polymorphisms with autoimmune thyroid diseases in Tunisian population

Mestiri

Zaaber

Inoubli

et al. 2020

Int J Immunogenetics

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Autoimmune thyroid diseases (AITD) including Graves' disease (GD) and Hashimoto's thyroiditis (HT) are complex genetic diseases. Th2 cytokines act on the development of AITD. This study was conducted on Tunisian patients with AITD to investigate the association of Th2 cytokine gene polymorphisms and haplotype combination with GD or HT risk. A total of 156 controls, 160 patients with HT and 88 patients with GD were genotyped for IL-4 rs2243250, IL-5 rs2069812, IL-6 rs1800796 and IL-13 rs1800925 polymorphisms by PCR-RFLP. The AITD risk was assessed by a logistic regression analysis using the SNP stats statistical program. False-positive report probability (FPRP) was estimated to evaluate significant findings. IL-13 rs1800925 was associated with GD, after adjustment for age and gender, in codominant, dominant and allele genetic models (p = .0072; p = .0018; p = .012, respectively). Significant association of the IL-6 rs1800796C/G genotype with GD was also detected (p = .025).Furthermore, increased risk of HT was still found for IL-13 rs1800925T allele (p = .039, OR = 1.39) and for IL-4 rs2243250T/T genotype both in codominant (p = .033, OR = 2.59) and recessive (p = .011, OR = 2.73) models after adjustment for age and gender. Interestingly, haplotype analysis performed on the IL-4, IL-5 and IL-13 genes revealed a high risk of HT with CTT haplotype (p = .008, OR = 2.12). However, the CCT haplotype is a protective factor (OR = 0.36). Patients carrying the CT haplotype with only one minor allele had a moderate risk of HT (OR = 1.56). The FPRP analysis showed that the association of IL-13 rs1800925 polymorphism with GD and HT and the association of CTT haplotype with HT were noteworthy. In conclusion, the IL-4, IL-5, IL-6 and IL-13 polymorphism may play a role in susceptibility to GD and HT in the Tunisian population. Furthermore, gene-gene interaction between the IL-4, IL-5 and IL-13 significantly increases the risk of AITD. Further studies with larger numbers of individuals are needed to confirm the results. K E Y W O R D Sautoimmune thyroid diseases, IL-13, IL-4, IL-5, IL-6, polymorphism | 295 MESTIRI ET al.

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“…Among these, IL-4 rs2243250, rs2070874 and rs79071878 polymorphisms are three intensively studied variants. Previous studies have demonstrated that the T allele of IL-4 rs2243250 and rs2070874 polymorphisms can increase binding of nuclear transcription factors to the promoter region of the IL-4 gene, and thus lead to increased transcription of IL-4 ( 32 , 43 ). In addition, the rs79071878 polymorphism may also affect the transcription activity of IL-4 ( 54 ).…”

Section: Discussionmentioning

confidence: 99%

Associations of common IL-4 gene polymorphisms with cancer risk: A meta-analysis

Jia

Xie

Shi

et al. 2017

Molecular Medicine Reports

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Abstract. Cancer incidence is dramatically increasing worldwide, therefore improved prediction and therapeutic methods are needed. Single nucleotide polymorphisms in cytokine genes may contribute to carcinogenesis. Interleukin (IL)-4 gene polymorphisms have been intensively studied with regard to their associations with cancer. However, the results of these previous studies remain inconclusive. The present study, therefore, aimed to conduct a meta-analysis of previously published studies in order to clarify the association of IL-4 with cancer risk. Eligible published articles were searched in Medline, PubMed, Embase and China National Knowledge Infrastructure databases up to March 2016. Odds ratios and 95% confidence intervals were used to identify potential associations between IL-4 genetic polymorphisms and the risk of cancer. A meta-analysis was then performed on 10,873 patients and 14,328 controls for IL-4 rs2243250 polymorphism, 3,970 patients and 5,686 controls for IL-4 rs2070874 polymorphism, and 1,896 patients and 2,526 controls for IL-4 rs79071878 polymorphism. A significant association with cancer risk was observed for rs2243250 and rs79071878 polymorphisms. In the subgroup analysis by cancer type, rs2243250 polymorphism was demonstrated to be associated with an increased risk of gastric cancer and breast cancer, rs2070874 polymorphism was correlated with leukemia and oral carcinoma, and rs79071878 polymorphism was relevant to bladder carcinoma risk. In the subgroup analysis by ethnicity, IL-4 rs2243250 polymorphism was demonstrated to be associated with cancer risk in both Caucasian and Asian populations, rs2070874 was associated with cancer risk in Asian populations, while rs79071878 polymorphism was associated with cancer risk in Caucasian populations. In conclusion, the present results suggested that the IL-4 rs2243250 and rs79071878 polymorphisms were associated with cancer susceptibility. Further subgroup analyses revealed that the effects of IL-4 gene polymorphisms on cancer risk may vary by cancer type and by

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Impact of Single Nucleotide Polymorphism in IL-4, IL-4R Genes and Systemic Concentration of IL-4 on the Incidence of Glioma in Iraqi Patients

Cited by 16 publications

References 43 publications

Relationship between circulating inflammatory factors and glioma risk and prognosis: A meta‐analysis

Relationship between circulating inflammatory factors and glioma risk and prognosis: A meta‐analysis

Association of cytokine Th2 gene polymorphisms with autoimmune thyroid diseases in Tunisian population

Associations of common IL-4 gene polymorphisms with cancer risk: A meta-analysis

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