Impact of Skeletal Muscle Mass on Long-Term Adverse Cardiovascular Outcomes in Patients With Chronic Kidney Disease

Harada, Kazuhiro; Suzuki, Susumu; Ishii, Hideki; Aoki, Toshijiro; Hirayama, Kenshi; Shibata, Yohei; Negishi, Yosuke; Sumi, Takuya; Kawashima, Kayoko; Kunimura, Ayako; Shimbo, Yusaku; Tatami, Yosuke; Kawamiya, Toshiki; Yamamoto, Daisuke; Morimoto, Ryo; Yasuda, Yoshinari; Murohara, Toyoaki

doi:10.1016/j.amjcard.2017.01.003

Cited by 68 publications

(58 citation statements)

References 24 publications

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“…Recently, sarcopenia has become a serious problem in older patients with type 2 diabetes, because of the increasing number of older patients . Sarcopenia, the age‐associated loss of muscle mass and function, is now known as a risk of cardiovascular disease (CVD) and mortality . Sarcopenia is usually defined by low muscle quality, using gait speed and/or handgrip strength, and low muscle mass, using dual‐energy X‐ray absorptiometry, bioelectrical impedance analysis (BIA), magnetic resonance imaging or computed tomography …”

Section: Introductionmentioning

confidence: 99%

Sarcopenia is associated with blood pressure variability in older patients with type 2 diabetes: A cross‐sectional study of the KAMOGAWA‐DM cohort study

Hashimoto

Kaji

Sakai

et al. 2018

Geriatrics Gerontology Int

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Section: Introductionmentioning

confidence: 99%

Sarcopenia is associated with blood pressure variability in older patients with type 2 diabetes: A cross‐sectional study of the KAMOGAWA‐DM cohort study

Hashimoto

Kaji

Sakai

et al. 2018

Geriatrics Gerontology Int

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“…The psoas muscle is relatively lean (compared to thigh muscles, which are often used for evaluation of sarcopenia), not prone to temporary fluctuations in mass, and its APCT measurements are easy to obtain and widely reproducible [12]. PMA measurements in abdominal imaging are good surrogates of sarcopenia and indicate frailty and poor outcomes in patients with chronic kidney disease [22, 23] and those undergoing a variety of cardiac and noncardiac surgeries [11, 12, 24, 25] or intravascular procedures [11, 19]. In the present study, we found that defining sarcopenia based on the lowest tertile of gender-based PMA measurement (≤5.40 cm 2 in men and ≤3.60 cm 2 in women) on APCT in patients with HF who are hospitalized may identify those who are at a high risk of intermediate and late mortality in the postdischarge period.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Low Skeletal Muscle Mass Independently Predicts Mortality in Patients with Chronic Heart Failure after an Acute Hospitalization

et al. 2019

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Background: Heart failure (HF) is a syndrome associated with exercise intolerance, and its symptoms are more common in patients with low skeletal muscle mass (SMM). Estimation of muscle mass can be cumbersome and unreliable, particularly in patients with varying body weight. The psoas muscle area (PMA) can be used as a surrogate of sarcopenia and has been associated with poor outcomes in other populations. Objectives: The aim of this study was to assess if sarcopenia is associated with the survival of patients with HF after an acute hospitalization. Method: We retrospectively studied a cohort of 160 patients with HF who had abdominopelvic computed tomography during an acute hospitalization. We obtained standardized measurements of their PMA and defined sarcopenia as the lowest gender-based tertile of the said area. The patients were followed until death or discontinuation of care. We used Kaplan-Meier estimates and Cox regression analysis to assess the relationship between sarcopenia and all-cause mortality. Results: We found that the 52 patients with sarcopenia had 4.5 times the risk of all-cause mortality at 1 year compared to the rest of the cohort (CI 1.784–11.765; p = 0.0016) after adjusting for significant covariates. Stratification by age and sex revealed that this association could be limited to males and patients < 75 years old. Conclusion: The PMA, used as a surrogate of low SMM, is independently associated with an increased risk of late mortality after an acute hospitalization in patients with HF.

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“…In the area of nephrology, several recent studies have suggested that low muscle mass is associated with an adverse cardiovascular outcome and high mortality in chronic kidney disease (CKD) patients, including patients on dialysis [13][14][15][16]. Although there are studies on the relationship between muscle mass and renal disease, most of them are cross-sectional in nature and there is little research published to date on whether a decrease in muscle mass can cause renal injury or CKD.…”

Section: Introductionmentioning

confidence: 99%

Low Skeletal Muscle Mass Predicts Incident Dipstick Albuminuria in Korean Adults without Chronic Kidney Disease: A Prospective Cohort Study

Lim

Lee

Kim

et al. 2018

Nephron

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Background: Previous cross-sectional studies have shown that low muscle mass is associated with albuminuria in the general population. However, the longitudinal association of low muscle mass with the development of albuminuria is not well known at this time. Methods: We evaluated 48,101 individuals without chronic kidney disease (CKD) who underwent 2 health check-ups in 2012 and 2016. Participants’ skeletal muscle masses were measured using a bioelectrical impedance analyzer and compared via a skeletal muscle mass index (SMI; SMI [%] = total skeletal muscle mass [kg]/body weight [kg] × 100). Urine albumin was determined by dipstick semi-quantitative analysis and incident albuminuria was defined as ≥1+ dipstick albumin at the time of the second check-up. We used logistic regression analysis to determine the relationship between skeletal muscle mass and incident albuminuria. Results: The study participants were divided into quartiles according to baseline SMI. After 4 years, 305 cases of incident albuminuria were observed. The cumulative incidences of albuminuria were 0.78, 0.66, 0.62, and 0.47% for the first through fourth quartiles of SMI respectively. Multivariable logistic analysis revealed that the ORs (95% CIs) for incident albuminuria were 1.63 (1.05–2.55) in the first quartile compared with those in the fourth quartile and 1.40 (1.05–1.88) in the participants with sarcopenia versus those without sarcopenia. Conclusions: Low skeletal muscle mass was independently associated with the development of dipstick albuminuria after 4 years in Korean adults without CKD. Further research is needed to verify the role of low muscle mass in the development of albuminuria and renal injury.

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Impact of Skeletal Muscle Mass on Long-Term Adverse Cardiovascular Outcomes in Patients With Chronic Kidney Disease

Cited by 68 publications

References 24 publications

Sarcopenia is associated with blood pressure variability in older patients with type 2 diabetes: A cross‐sectional study of the KAMOGAWA‐DM cohort study

Sarcopenia is associated with blood pressure variability in older patients with type 2 diabetes: A cross‐sectional study of the KAMOGAWA‐DM cohort study

Low Skeletal Muscle Mass Independently Predicts Mortality in Patients with Chronic Heart Failure after an Acute Hospitalization

Low Skeletal Muscle Mass Predicts Incident Dipstick Albuminuria in Korean Adults without Chronic Kidney Disease: A Prospective Cohort Study

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