Impact of sleep disorder treatment on fatigue in multiple sclerosis

Côté, Isabelle; Trojan, DA; Kamińska, Marta; Cardoso, Mauro José Lahm; Benedetti, Andrea; Weiss, D; Robinson, Ann; Bar‐Or, Amit; Lapierre, Yves; Kimoff, R. John

doi:10.1177/1352458512455958

Cited by 72 publications

(50 citation statements)

References 36 publications

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“…However, our results revealed that the decrease in general fatigue among patients in the cooling group (Δ = -6.0, effect size = 2.8) is higher than that reported by Côté et al [28] in PwMS undergoing treatment for sleep disorders (Δ = -3.1, effect size = 0.82). This result suggests that physical activity has a positive impact on general fatigue and highlights the potential influence of body cooling on PwMS during physical activity.…”

Section: Discussioncontrasting

confidence: 55%

Effects of a Training Program Involving Body Cooling on Physical and Cognitive Capacities and Quality of Life in Multiple Sclerosis Patients: A Pilot Study

et al. 2017

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Objective: Two methods using exercise and body cooling could influence the well-being of patients with multiple sclerosis (PwMS). The aim of this study was to determine whether wearing a cooling vest during a physical training program could increase the cognitive and physical capacities and quality of life in PwMS. Methods: Eighteen PwMS (49.6 ± 8 years; Expanded Disability Status Score 5.0 ± 1.0) were randomly assigned to a cooling or control group. PwMS underwent a 7-week physical training program. In the cooling group, PwMS wore a cooling vest during each training session, whereas in the control group, PwMS wore a cotton T-shirt. Before and after the training program, both groups completed the Isaacs Set Test (IST), Trail Making Test A-B (TMT A-B), SEP-59, Multidimensional Fatigue Inventory and performed a 6-minute walk test (6MWT). Results: The cooling group showed significantly (p < 0.05) improved performance for IST, TMT A and 6MWT. Their emotional well-being and cognitive functions investigated in SEP-59 were significantly (p < 0.05) improved, and general and physical fatigue significantly (p < 0.05) decreased. Conclusions: This physical training program combined with a cooling strategy could have a significant positive influence on both cognitive and physical performances, perceived fatigue and emotional well-being in heat-sensitive PwMS.

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Section: Discussioncontrasting

confidence: 55%

Effects of a Training Program Involving Body Cooling on Physical and Cognitive Capacities and Quality of Life in Multiple Sclerosis Patients: A Pilot Study

et al. 2017

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“…Two independent open follow-up studies have demonstrated an improvement of MS-related fatigue by the treatment of underlying sleep disorders [22,23], but we need randomized controlled studies in order to confirm these findings. Two months after treatment with cortisone 1 g/day for 3 days, the hypothalamic lesions were diminished and the MSLT showed a mean sleep latency of 17.4 min and only one SOREMP.…”

Section: Future Research Directionsmentioning

confidence: 93%

“…In both studies, the follow-up studies showed that sleep medical treatment started subsequently improved fatigue [22,23].…”

Section: Sleep-related Breathing Disordersmentioning

confidence: 97%

Sleep Disorders in Multiple Sclerosis. Review

Veauthier

2015

Curr Neurol Neurosci Rep

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Sleep disorders are common in patients with multiple sclerosis (MS) and play a crucial role in health and quality of life; however, they are often overlooked. The most important sleep disorders in this context are as follows: insomnia, restless legs syndrome, periodic limb movement disorders, and sleep-related breathing disorders (SRBD). It is unclear if MS-related processes (lesions, brain atrophy) can cause symptomatic forms of sleep apnea. MS-related narcolepsy-like symptoms are described in the literature and, in some cases, have resolved with methylprednisolone pulse therapy. Similarly, REM sleep behavior disorder (RBD) is very rare in MS, but it can be an initial sign of MS where cortisone therapy may be helpful and can be taken into account in this specific context. Independent diagnosis and treatment is required for all of the abovementioned conditions. Treating physicians and neurologists should be aware of these comorbidities and initiate specific therapy. Highly fatigued or sleepy MS patients should have polysomnography in order not to overlook these diagnoses.

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“…Here, we use data obtained from the baseline evaluation and first night PSG results. Further details of this study are described elsewhere (Kaminska et al, 2011;Côté et al, 2013). The Institutional Review Board of the participating institution approved the study.…”

Section: Methodsmentioning

confidence: 99%

“…OSAH was defined by an apnea-hypopnea index (AHI) of ≥ 15 events per hour of sleep (Kaminska et al, 2011;Côté et al, 2013).…”

Section: Objective Sleep Datamentioning

confidence: 99%

A Comparison of Various Data Reduction Procedures in a Multiple Sclerosis Sleep Study

et al. 2018

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Abstract:Clinical studies often deal with data sets with numerous variables. As a result of the similarities between the variables, we frequently observe the presence of multicollinearity in the data. This study aimed to apply different data reduction strategies to sleep study variables in multiple sclerosis (MS) patients. The main objective was to use various data reduction strategies to explain a subjective measure of sleep quality (Pittsburgh Sleep Quality Index: PSQI) by the objective measures of sleep quality obtained during complete inlaboratory overnight polysomnography. Overall, we found that few objective measures of sleep quality were important in explaining the subjective PSQI, based on the results of various well accepted statistical methods. Total sleep time was found to be the most important feature of objective sleep quality for explaining subjective sleep quality among all other investigated objective sleep quality variables in most of the approaches investigated in this study. The LASSO method for estimation worked best in terms of interpretability among all the approaches considered.

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Impact of sleep disorder treatment on fatigue in multiple sclerosis

Abstract: Treatment of sleep disorders can improve fatigue and other clinical outcomes in MS.

Cited by 72 publications

References 36 publications

Effects of a Training Program Involving Body Cooling on Physical and Cognitive Capacities and Quality of Life in Multiple Sclerosis Patients: A Pilot Study

Effects of a Training Program Involving Body Cooling on Physical and Cognitive Capacities and Quality of Life in Multiple Sclerosis Patients: A Pilot Study

Sleep Disorders in Multiple Sclerosis. Review

A Comparison of Various Data Reduction Procedures in a Multiple Sclerosis Sleep Study

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