Impact of sleep-disordered breathing on metabolic dysfunctions in patients with polycystic ovary syndrome

Chatterjee, Bidisha; Suri, Jyotsna; Suri, Jagdish Chander; Mittal, Pratima; Adhikari, Tulsi

doi:10.1016/j.sleep.2014.06.023

Cited by 38 publications

(33 citation statements)

References 41 publications

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“…In this study, waist-to-hip ratio was significantly correlated with AHI. Consistent with these findings, Chatterjee and coworkers showed that mean waist circumference, also a marker for central obesity, was not only higher in PCOS patients with OSA than the ones without OSA, but also correlated positively with the severity of OSA (13). All these studies have included mostly obese women, but in a study by Yang and coworkers, including only nonobese women, even though the AHI in the PCOS patients was not high enough to meet the OSA criteria, women with PCOS had more hypopneic–apneic events during sleep than the age- and BMI-matched control group, showing that risk of OSA in patients with PCOS is still increased without the direct effect of obesity (28).…”

Section: Discussionmentioning

confidence: 61%

“…In two studies, PCOS was defined by the presence of any two of the following three features: chronic oligomenorrhea, biochemical or clinical evidence of hyperandrogenism and polycystic ovaries on ultrasonography (13, 14). In the rest of the included studies, presence of both chronic anovulation/oligo-amenorrhea and hyperandrogenemia was the main criteria for PCOS diagnosis.…”

Section: Resultsmentioning

confidence: 99%

“…OSA was defined according to respiratory distress index, the number of apneas, hypopneas and respiratory effort-related arousals (RERA) per hour of sleep, in two studies (12, 13). In the rest of the included studies, AHI was used to define OSA.…”

Section: Resultsmentioning

confidence: 99%

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Polycystic ovary syndrome and the risk of obstructive sleep apnea: a meta-analysis and review of the literature

Helvacı

Karabulut

Demir

et al. 2017

Endocrine Connections

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Background and ObjectivePolycystic ovary syndrome (PCOS) has been reported to be associated with the development of obstructive sleep apnea (OSA). The objective of this meta-analysis is to assess the relationship between PCOS and OSA.MethodsA literature search was conducted to identify studies linking PCOS with the risk of OSA. Studies in which the presence of OSA was confirmed with overnight polysomnography were included. Random effects models were used to calculate pooled relative risks.ResultsEight studies conducted in adults and five studies conducted in adolescents were identified. The pooled OSA prevalence was 0.22 (95% confidence interval (CI): 0.08–0.40) in PCOS patients. The pooled prevalence of OSA was higher in adults (0.32, 95% CI: 0.13–0.55) than adolescents (0.08, 95% CI: 0.00–0.30). Risk of OSA was significantly increased in adult patients with PCOS (odds ratio (OR) 9.74, 95% CI: 2.76–34.41). Risk of OSA was not significantly increased in adolescents (OR: 4.54, 95% CI:0.56–36.43).ConclusionsThese findings demonstrate a significant association between PCOS and OSA in adult patients. Considering the increased risk for long-term cardiometabolic disorders associated with both PCOS and OSA, it is important to diagnose and treat OSA in patients with PCOS.

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Section: Discussionmentioning

confidence: 61%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Polycystic ovary syndrome and the risk of obstructive sleep apnea: a meta-analysis and review of the literature

Helvacı

Karabulut

Demir

et al. 2017

Endocrine Connections

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“…The literature underlines also other health side effects of sleep disturbances in this group of patients. OSA occurrence may cause serious intensification of metabolic disorders as well as the symptoms of hyperandrogenism [25]. In PCOS patients insulin resistance is observed, independently of obesity [18].…”

Section: Discussionmentioning

confidence: 99%

Sleep disturbances in women with polycystic ovary syndrome

Franik

Krysta

Madej

et al. 2016

Gynecological Endocrinology

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Sleep disturbances in women with Polycystic Ovary Syndrome (PCOS) have been reported in recent years. The majority of published studies are related to Obstructive Sleep Apnea (OSA) while not many researches have analyzed any other causes of sleep disturbances. A group of ninety five women with Polycystic Ovary Syndrome were enrolled into the study. Sleep disturbances were assessed using validated questionnaires. On the grounds of Athens Insomnia Scale (AIS) evaluation a clinically significant insomnia was ascertained in 12.6% of women with PCOS, while according to Insomnia Severity Index (ISI) in 10.5%. Clinically significant insomnia according to both AIS and ISI, occurred significantly more often in women with PCOS than in women without PCOS based on the chi-square test. The Mann-Whitney U test revealed statistically significant difference between women with and without PCOS based on total values of ISI. An excessive daytime sleepiness occurred at 7.4% of women with PCOS. Statistically significant dependance between: clinically significant insomnia in both AIS and ISI and excessive daytime sleepiness indicated by Epworth Sleepiness Scale (ESS) was observed. Sleep disorders are common in women with PCOS. Screening assessment of sleep disturbances should be a part of medical diagnostics in women with PCOS.

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“…

In response to Dr Rahul Katyal letter [1] in this issue of Sleep Medicine, I would like to clarify that among the sleep-disordered breathing (SDB) patients in our study [2], there were three outliers (ages 34, 39, and 42 years old). If we remove these outliers, the difference between the SDB and non SDB group with respect to age comes out to be non-significant.

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mentioning

confidence: 95%