Impact of smoking on oxidant/antioxidant status and oxidative stress index levels in serum of the university students

Ahmadkhaniha, Reza; Yousefian, Fatemeh; Rastkari, Noushin

doi:10.1007/s40201-021-00669-y

Cited by 16 publications

(6 citation statements)

References 15 publications

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“…Our study demonstrated that rats exposed to cigarette smoke have significantly higher plasma MDA levels than rats in the healthy control group. This result is in line with a previous study that showed lipid peroxidation is higher among smokers, usually accompanied by depletion of total antioxidant capacity [23][24][25] . Importantly, this study confirmed that the high level of MDA in rats exposed to cigarette smoke could be normalized by Rosella supplementation.…”

Section: Discussionsupporting

confidence: 93%

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The Protective effect of Hibiscus sabdariffa on Lung Damage in Rats due to Cigarette Smoke Exposure

Fulyani

Yudhistira

Istiadi

et al. 2023

dmj

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Background: Cigarette smoke consists of many free radicals that can reduce antioxidants in the body and further trigger oxidative stress. The state of oxidative stress can be minimized through antioxidant supplementation. Hibiscus sabdariffa (Rosella) is a herbal plant reported to be rich in antioxidants.Objective: To investigate the protective effect of Rosella extract on the microstructure of the lung and plasma Malondialdehyde (MDA) levels of rats exposed to cigarette smoke.Methods: This research is an experimental study with a post-test-only group design. A total of 36 male Sprague Dawley rats were randomly divided into six groups[L1] . Group K was given standard food and free access to water. Group K1, K2, P1, P2, and P3 were exposed to 4 cigarettes/day for 30 consecutive days. Before cigarette smoke exposure, each group received treatment with 1 mL saline (K1), vitamin E 0.2 g/kg b.w. (K2), and infused Rosella 0.25 g/kg b.w. (P1), 0.5 g/kg b.w. (P2), and 1 g/kg b.w. (P3). Plasma MDA levels were measured by the TBARS method. Statistical analysis was performed with one way ANOVA test and continued with a post hoc test.Results: Circulated MDA levels of groups K, K1, K2, P1, P2, and P3 were 1.84 ± 0.18 nmol/mL, 9.57 ± 0.27 nmol/mL, 2.24 ± 0.10 nmol/mL, 4.93 ± 0.31 nmol/mL 3.85 ± 0.55 nmol/mL, and 2.62 ± 0.37 nmol/mL respectively. Cigarette smoke exposure in group K showed significantly higher MDA levels (K versus K1; p < 0.001). The administration of rosella infusion (P1, P2, P3) and or vitamin E supplementation (K2) can significantly suppress the plasma MDA levels due to cigarette smoke exposure ( p < 0.05). The administration of Rosella flower infusion 1 g/kg b.w. has an antioxidant effect similar to vitamin E supplementation 0.2 g/kg b.w. (p = 0.268).Conclusion: The administration of Rosella flower infusion could prevent lung damage from oxidative stress induced by cigarette smoke exposure. Keywords: Cigarette, Hibiscus sabdariffa,MDA, Oxidative stress.

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Section: Discussionsupporting

confidence: 93%

“…This unchecked proliferation causes collagen deposition, fibroblast proliferation, and thickening of the pulmonary capillaries. Alveolar collapse and interstitial and intra-alveolar fibrosis emerge when it gets chronic 23 . Antioxidant and anti-inflammatory properties are seen in Hibiscus sabdariffa (HS) constituents.…”

Section: Discussionmentioning

confidence: 99%

The Protective effect of Hibiscus sabdariffa on Lung Damage in Rats due to Cigarette Smoke Exposure

Fulyani

Yudhistira

Istiadi

et al. 2023

dmj

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“…Meanwhile, Vitamin E could mitigate the oxidative stress induced by alcohol [ 39 ]. As is well known, smoking increases oxidative damage and decreases the antioxidant defense system [ 40 ]. What’s more, it may take more than 10 years until the redox balance is restored, indicating that tobacco is extraordinarily harmful for the oxidative defense system [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Dietary Total Antioxidant Capacity of Antioxidant Vitamins and the Risk of Stroke among US Adults

Yang¹,

Jia²,

Wang³

et al. 2022

Antioxidants

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The intake of antioxidant vitamins can scavenge free radicals and reduce oxidative stress, which may be beneficial for stroke. However, the relationship between total antioxidant capacity (TAC) of antioxidant vitamins and stroke is controversial. This study aims to investigate the association between dietary TAC and the risk of stroke in US adults. This study included participants over 20 years old from the 2001–2018 National Health and Nutrition Examination Survey (NHANES). Data from two 24 h dietary recalls were used to estimate the usual intake of antioxidant vitamins. TAC was calculated by the vitamin C equivalent antioxidant capacity reference values of individual antioxidant vitamins. Survey-weighted generalized linear models were performed to evaluate the relationship between TAC and the risk of stroke. A restricted cubic spline regression model was used to investigate the dose–response association. A total of 37,045 participants was involved, of whom 1391 suffered a stroke. Compared with the first tertile, the participants in the second tertile of TAC showed a lower risk of stroke (OR = 0.788, 95% CI: 0.662, 0.936) after adjusting for potential risk factors. The dose–response analysis showed a gradual increase in the risk of stroke as TAC decreases. Subgroups analyses indicated that this association was primarily in the population of those aged over 60 years old, who were female, consumed alcohol, were a former smoker and inactive. The sensitivity analysis presented consistent results. These results suggest that deficiency of dietary TAC was associated with an increased risk of stroke, particularly in populations with underlying oxidative stress injury.

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“…Therefore, smokers are subjected to an increased oxidative stress situation, which can result in an imbalance between oxidants and antioxidants. 25 In vitro studies found that the lipid components of myelin sheath are highly vulnerable to oxidative stress. 26 Therefore, it is possible that damage to myelin sheath has caused the reduction in axonal conductivity.…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological Evaluation of Common Peroneal Nerve in Chronic Cigarette Smokers.

Habiba Akter,

Munmun Hossain,

Syed Minhaj Uddin Ahmed

et al. 2024

Khwaja Yunus Ali Medical College Journal

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Background: Researchers have identified multiple negative health effects of smoking on the respiratory and cardiovascular systems. It was recently reported that substances in cigarette smoke also have pathological effects on peripheral nerves, which causes neuronal impairment. The common peroneal nerve conduction study is an essential electrodiagnostic test of the lower limb for the detection of peripheral motor nerve dysfunction.Objectives: To assess the potential influence of smoking on the electrophysiological status of common peroneal nerve in young male chronic cigarette smokers.Materials and Methods: This case-control study was conducted in the Department of Physiology, Sir Salimullah Medical College, Dhaka, from July 2017 to June 2018, including thirty male cigarette smokers aged 25 to 40 years. For comparison, another thirty age and BMI-matched healthy male non-smoker subjects were selected in the control group. The electrophysiological parameters (distal latency, amplitude, and motor nerve conduction velocity) of the left common peroneal nerve were evaluated by standard methods in the Department of Neurology, Dhaka Medical College Hospital. For the statistical analysis, an independent t-test was performed.Result: In this study, the mean distal latency of the common peroneal nerve was slightly prolonged, while the mean amplitude was slightly reduced in smokers. However, these changes were not statistically significant. However, the motor nerve conduction velocity was significantly (p ˂ 0.05) slower in cigarette smokers compared to non-smokers.Conclusion: Chronic cigarette smoking causes significant impairment of common peroneal motor nerve conduction, while it does not affect the amplitude in young individuals. KYAMC Journal Volume: 14, No: 03, October 2023: 111-115.

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Impact of smoking on oxidant/antioxidant status and oxidative stress index levels in serum of the university students

Cited by 16 publications

References 15 publications

The Protective effect of Hibiscus sabdariffa on Lung Damage in Rats due to Cigarette Smoke Exposure

The Protective effect of Hibiscus sabdariffa on Lung Damage in Rats due to Cigarette Smoke Exposure

Association between Dietary Total Antioxidant Capacity of Antioxidant Vitamins and the Risk of Stroke among US Adults

Electrophysiological Evaluation of Common Peroneal Nerve in Chronic Cigarette Smokers.

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