Impact of SMS/GPRS Printers in Reducing Time to Early Infant Diagnosis Compared With Routine Result Reporting: A Systematic Review and Meta-Analysis

Vojnov, Lara; Markby, Jessica; Boeke, Caroline E.; Penazzato, Martina; Urick, Brittany; Ghadrshenas, Anisa; Harris, Lindsay; Ford, Nathan; Peter, Trevor

doi:10.1097/qai.0000000000001526

Cited by 18 publications

(12 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…28 In a 2016 systematic review, 29 the effect of mHealth interventions on improving PMTCT and early infant diagnosis was summarised from five studies, with a significant increase reported in early infant diagnosis uptake at 6 weeks post partum (pooled relative risk 1·2, 95% CI 1·1–1·3). Findings of a 2017 systematic review 30 ascertained that SMS and general packet radio service (GPRS) printers reduced turnaround time for infant PCR test results by 25% compared with a paper-based courier (51·1 days vs 68·0 days). Our trial provides the most comprehensive evidence to date of the success of an mHealth intervention to improve quality and efficiency across the complete early infant diagnosis cascade of care.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the HIV Infant Tracking System (HITSystem) to optimise quality and efficiency of early infant diagnosis: a cluster-randomised trial in Kenya

et al. 2018

View full text Add to dashboard Cite

Summary Background The HIV Infant Tracking System (HITSystem) is a web-based intervention linking providers of early infant diagnosis, laboratory technicians, and mothers and infants to improve outcomes for HIV-exposed infants. We aimed to evaluate the efficacy of the HITSystem on key outcomes of early infant diagnosis. Methods We did a cluster-randomised trial at six hospitals in Kenya, which were matched on geographic region, resource level, and volume of patients (high, medium, and low). We randomly allocated hospitals within a matched pair to either the HITSystem (intervention; n=3) or standard of care (control; n=3). A random number generator was used to assign clusters. Investigators were unaware of the randomisation process. Eligible participants were mothers aged 18 years or older with an infant younger than 24 weeks presenting for their first early infant diagnosis appointment. The primary outcome was complete early infant diagnosis retention, which was defined as receipt of all indicated age-specific interventions until 18 months post partum (for HIV-negative infants) or antiretroviral therapy initiation (for HIV-positive infants). Analysis was per protocol in all randomised pairs judged eligible, excluding infant deaths and those who moved or were transferred to another health facility. Modified intention-to-treat sensitivity analyses judged all infant deaths and transfers as incomplete early infant diagnosis retention. Separate multivariable logistic regression analyses were done with intervention group, hospital volume, and significant covariates as fixed effects. This trial is registered with ClinicalTrials.gov, number NCT02072603; the trial has been completed. Findings Between Feb 16, 2014, and Dec 31, 2015, 895 mother–infant pairs were enrolled. Of these, 87 were judged ineligible for analysis, 26 infants died, and 92 pairs moved or were transferred to another health facility. Thus, data from 690 mother–infant pairs were analysed, of whom 392 were allocated to the HITSystem and 298 to standard of care. Mother–infant pairs were followed up to Sept 30, 2017. Infants diagnosed as HIV-positive were followed up for a median of 2·1 months (IQR 1·6–4·8) and HIV-negative infants were followed up for a median of 17·0 months (IQR 16·6–17·6). Infants enrolled in the HITSystem were significantly more likely to receive complete early infant diagnosis services compared with those assigned standard of care (334 of 392 [85%] vs 180 of 298 [60%]; adjusted odds ratio [OR] 3·7, 95% CI 2·5–5·5; p<0·0001). No intervention effect was recorded at high-volume hospitals, but strong effects were seen at medium-volume and low-volume hospitals. Modified intention-to-treat analyses for complete early infant diagnosis were also significant (334 of 474 [70%] vs 180 of 334 [54%]; adjusted OR 2·0, 95% CI 1·4–2·7; p<0·0001). No adverse events related to study participation were reported. Interpretation The HITSystem intervention is effective and feasible to implement in low-resource settings. The HITSystem algorithms have b...

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of the HIV Infant Tracking System (HITSystem) to optimise quality and efficiency of early infant diagnosis: a cluster-randomised trial in Kenya

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Future research should be conducted on ways to strengthen sputum collection transportation and testing the NTP would need to know why delivery of results back to requesting facilities was such a challenge so as to put in appropriate measures in ensuring adherence to national guidelines on sputum collection, transportation and delivery of results. The NTP would need to explore if modern technologies such as a short message services (SMSs) which has improved result turn-around times in early infant diagnosis as compared to courier-based reporting would improve the challenges in the programme [ 10 ]. This may ultimately improve treatment outcomes as patients receive results on time.…”

Section: Discussionmentioning

confidence: 99%

“…Patients are also offered provider-initiated HIV testing services in the MDR-TB pre-treatment phase and those found to be HIV positive are assessed for initiation on antiretroviral therapy (ART) and cotrimoxazole preventive therapy (CPT). As per the national guidelines in use during the study period, they were initiated on a fixed-dose combination once-daily pill of Tenofovir v+ Lamuvidine (or Emtricitabine) + Efavirenz (TDF+3TC) or (FTC)+EFV) as the preferred first-line ART regimen among adult PLHIV and abacavir+ lamuvidine + efavirenz or (Lopinavir/r) (ABC + 3TC + EFV (or Lop/r)) as the preferred first-line ART regimen in children living with HIV [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

The role of bacteriological monitoring using culture and drug susceptibility tests (CDST) on treatment outcomes among MDR/RR-TB patients on treatment: a cohort analysis of patients enrolled on treatment 2010-2015 in Zimbabwe

Matambo¹,

Mutero-Munyati²,

Pepuka³

et al. 2021

Pan Afr Med J

View full text Add to dashboard Cite

Introduction an estimated 25% of the world population is infected with Mycobacterium tuberculosis. In 2017, new tuberculosis cases were estimated at 10 million, while 1.6 million tuberculosis related deaths were recorded, 25% residing in Africa. Treatment outcomes of multi drug resistant Tuberculosis patients in Zimbabwe has been well documented but the role of bacteriological monitoring on treatment outcomes has not been systematically evaluated. The objective of the study was to determine the role of bacteriological monitoring using culture and drug susceptibility tests on treatment outcomes among patients with multi drug resistant tuberculosis. Methods a retrospective, secondary data analysis was conducted using routinely collected data of patients with multi drug resistant TB in Zimbabwe. Frequencies were used to summarize categorical variables and a generalized linear model with a log-link function and a Poisson distribution was used to assess factors associated with unfavourable outcomes. The level of significance was set at P-Value<0.05. Results about the study collected data from 473 records of patients with an average age of 36.35 years. Forty-nine percent (49%) were male and 51% were female. Results showed that when a patient has baseline culture result missing, has no culture conversion result, regardless of having a follow up culture and drug susceptibility test result, the risk of developing unfavourable outcomes increase by 3.9 times compared to a patient who has received all the three (3) bacteriological monitoring tests. Conclusion results highlights the need for consistent bacteriological monitoring of patients to avert unfavourable treatment outcomes.

show abstract

“…Post-NTBRL leakages in SL-DST results may be reduced if the NTP introduces electronic reporting to increase both speed and access to SL-DST results by health facilities. Short message services (SMSs) have improved result turn-around times in early infant diagnosis as compared to courier-based reporting (Vojnov et al, 2017). The NTP may also consider investing in point-of-care diagnostics that offer sensitivity patterns to FQ and SLIs even in peripheral areas to ensure equity of access to SL-DSTs (Xie et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Access to second-line drug susceptibility testing results among patients with Rifampicin resistant tuberculosis after introduction of the Hain Line Probe Assay in Southern provinces, Zimbabwe

Timire

Sandy

Kumar

et al. 2019

International Journal of Infectious Diseases

View full text Add to dashboard Cite

To determine the proportion of rifampicin-resistant tuberculosis (RR-TB) patients who accessed second-line drug susceptibility testing (SL-DST) results following introduction of the Hain technology in southern provinces, Zimbabwe. Design: Cohort study using secondary data. Results: Xpert MTB/RIF results were used to identify 133 RR-TB patients for this study. Their mean age (SD) was 37.9 (11.1) years, 83 (62%) were males and 106 (80%) were HIV-infected. There were 6 (5%) participants who had pre-treatment attrition. Of the 133 pulmonary TB (PTB) patients, 117 (80%) had additional sputum specimens collected; 96 (72%) specimens reached the National TB Reference Laboratory (NTBRL); 95 (71%) were processed; 68 (51%) had SL-DST results. Only 53 (40%) SL-DST results reached the peripheral facilities. Median time from specimen reception at the NTBRL to SL-DSTs was 40 days, interquartile range (IQR: 28-67). Median time from presumptive diagn7osis of RR-TB by health care worker to SL-DST results was 50 days (IQR: 39-80), and increased to 79 days (IQR: 39-101) in facilities >250 km from the NTBRL. The proportion with any fluoroquinolone resistance was 9 (13.2%). Conclusion: Although RR-TB patients with PTB were initiated timely on treatment, access to SL-DSTs by facilities needs improvement. Health inequities exist as remote areas are less likely to get SL-DST results in time.

show abstract

Impact of SMS/GPRS Printers in Reducing Time to Early Infant Diagnosis Compared With Routine Result Reporting: A Systematic Review and Meta-Analysis

Cited by 18 publications

References 20 publications

Evaluation of the HIV Infant Tracking System (HITSystem) to optimise quality and efficiency of early infant diagnosis: a cluster-randomised trial in Kenya

Evaluation of the HIV Infant Tracking System (HITSystem) to optimise quality and efficiency of early infant diagnosis: a cluster-randomised trial in Kenya

The role of bacteriological monitoring using culture and drug susceptibility tests (CDST) on treatment outcomes among MDR/RR-TB patients on treatment: a cohort analysis of patients enrolled on treatment 2010-2015 in Zimbabwe

Access to second-line drug susceptibility testing results among patients with Rifampicin resistant tuberculosis after introduction of the Hain Line Probe Assay in Southern provinces, Zimbabwe

Contact Info

Product

Resources

About