Impact of socio-behavioral measures implemented during the SARS-CoV-2 pandemic on the outcomes of febrile neutropenia episodes in pediatric cancer patients: a single center quasi-experimental pre-post study

Nessle, Charles Nathaniel; Braun, Thomas; Chopra, Vineet; Choi, Sung Won; Mody, Rajen

doi:10.1080/08880018.2022.2107746

Cited by 2 publications

(3 citation statements)

References 30 publications

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“…In that respect, the preventive strategy for FN also needs to be applied differently depending on the patient's characteristics and expected etiology; however, the current practice is considered to too simplistic and is focused on only a speci c group. Our data and some recent studies have shown that the incidence of FN, especially upper respiratory infection, signi cantly decrease after COVID 19 outbreak (19,20). In our study, the pattern of our relatively lower risk patients was different from the general known epidemiological pattern of FN (Unexplained fever, 87.5%; clinically documented infection, 6.3%; and microbiologically documented infection, 6.3% respectively).…”

Section: Discussioncontrasting

confidence: 87%

“…At the beginning of our study, there was no report on the relationship between FN and COVID 19 outbreak, however, several recent research results have been reported. The result of each study though similar in some aspect, differed as highlighted in table 5 (19)(20)(21)(22)(23). Nessle et al reported only a reduced incidence of upper respiratory infection associated FN, and not overall FN episodes among pediatric patients with cancer during post-COVID 19 era (19).…”

Section: Discussionmentioning

confidence: 93%

“…The result of each study though similar in some aspect, differed as highlighted in table 5 (19)(20)(21)(22)(23). Nessle et al reported only a reduced incidence of upper respiratory infection associated FN, and not overall FN episodes among pediatric patients with cancer during post-COVID 19 era (19). Three other retrospective studies showed a reduction in the overall FN incidence after COVID 19 outbreak in relatively larger dataset.…”

Section: Discussionmentioning

confidence: 93%

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Importance of standard precautions to febrile neutropenia prevention in patients with cancer during COVID 19 outbreak

Park,

Yang,

Han

et al. 2024

Preprint

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Purpose Intensive cytotoxic chemotherapy increases the risk of infection in patients with cancer by inducing bone marrow suppression and mucosal injury. Febrile neutropenia (FN) is the most important clinical adverse event in patients with cancer who receiving cytotoxic chemotherapy. To prevent FN, prophylactic antibiotics, colony stimulating factors (CSFs) and also standard precautions including hand and respiratory hygiene are generally recommended but the exact effect of non-pharmacologic intervention such as standard precaution has not been clearly proven in the clinical setting. we aimed to compare the incidence of FN between pre-coronavirus disease 19 (COVID 19) era versus post-COVID 19 era. Material and methods We retrospectively enrolled patients with breast cancer who received adjuvant adriamycin and cyclosphosphamide (AC) chemotherapy at Jeju national university hospital. Results In total, 149 patients well enrolled, including 94 who received AC chemotherapy in pre-COVDI 19 era and 55 who received at post-COVID 19 era. Sixteen (10.7%) patients experienced the FN. Fourteen events (14.9%) and two events (3.6%) were occurred in pre-COVID 19 and post-COVDI 19 era, respectively. The post-COVID 19 era was the only risk factor for FN. (p = 0.032) Conclusion We found an association between FN occurrence and COVID 19 outbreak; thus, providing indirect evidence of the importance of non-pharmacological measure to reduce FN risk in patients with cancer. Further research is required to confirm the standard precautions for FN prevention in patients with cancer.

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Section: Discussioncontrasting

confidence: 87%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%

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Importance of standard precautions to febrile neutropenia prevention in patients with cancer during COVID 19 outbreak

Park,

Yang,

Han

et al. 2024

Preprint

View full text Add to dashboard Cite

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Lesson from COVID-19 outbreak; importance of standard precautions to febrile neutropenia prevention in patients with breast cancer who received adjuvant chemotherapy: a retrospective observational study

Park,

Yang,

Han

et al. 2024

Ann Surg Treat Res

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Purpose Intensive cytotoxic chemotherapy increases the risk of infection in patients with cancer by inducing bone marrow suppression and mucosal injury. Febrile neutropenia (FN) is the most important clinical adverse event in patients with cancer receiving cytotoxic chemotherapy. To prevent FN, standard precautions including hand and respiratory hygiene are generally recommended, but the exact effect of non-pharmacologic intervention has not been clearly proven in the clinical setting. We aimed to compare the incidence of FN between the pre-coronavirus disease 19 (COVID-19) era vs. the post-COVID-19 era. Methods We retrospectively enrolled patients with breast cancer who received an adriamycin and cyclophosphamide (AC) regimen containing adjuvant chemotherapy at Jeju National University Hospital. We compared the incidence of FN between the pre- and post-COVID-19 period and analyzed characteristics of the event and other clinical risk factors. Results In total, 149 patients were enrolled, including 94 who received AC chemotherapy in the pre-COVID-19 era and 55 who received it in the post-COVID-19 era. Sixteen patients (10.7%) experienced FN. Fourteen (14.9%) and 2 events (3.6%) occurred in pre-COVID-19 and post-COVID-19 eras, respectively. The post-COVID-19 era was the only risk factor for FN (P = 0.032). Conclusion We found an association between FN occurrence and the COVID-19 outbreak, providing indirect evidence of the importance of non-pharmacological measures to reduce FN risk in patients with breast cancer. Further research is required to confirm the standard precautions for FN prevention in patients with cancer.

show abstract

Impact of socio-behavioral measures implemented during the SARS-CoV-2 pandemic on the outcomes of febrile neutropenia episodes in pediatric cancer patients: a single center quasi-experimental pre-post study

Cited by 2 publications

References 30 publications

Importance of standard precautions to febrile neutropenia prevention in patients with cancer during COVID 19 outbreak

Importance of standard precautions to febrile neutropenia prevention in patients with cancer during COVID 19 outbreak

Lesson from COVID-19 outbreak; importance of standard precautions to febrile neutropenia prevention in patients with breast cancer who received adjuvant chemotherapy: a retrospective observational study

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