Impact of Socioeconomic Status in Etiology and Management of Urinary Stone Disease

Ansari, M.S.; Gupta, Nsrc

doi:10.1159/000070130

Cited by 32 publications

(22 citation statements)

References 47 publications

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“…Studies show a high recurrence rate involving about 70% of the patients within 20 years after the first renal colic episode and of 50% from 4 to 5 years after the first episode (2). Many researchers have reported the serious impact of stone formation (3) and a potential reduction in the elevated expense through kidney stone pre- www.bjournal.com.br vention programs (4,5).…”

Section: Introductionmentioning

confidence: 99%

Anxiety and depression symptoms in recurrent painful renal lithiasis colic

Diniz

Blay

Schor

2007

Braz J Med Biol Res

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Several studies have reported that symptoms of anxiety and depression are significantly associated with diseases characterized by painful crises. However, there is little information about the psychological aspects of recurrent painful episodes of renal stone disease. Our objective was to evaluate the association of symptoms of anxiety, depression and recurrent painful renal colic in a case-control study involving 64 subjects (32 cases/32 controls) matched for age and sex. Cases were outpatients with a confirmed diagnosis of nephrolithiasis as per their case history, physical examination, image examination and other laboratory exams. Patients had a history of at least two episodes within a 3-year period, and were currently in an intercrisis interval. The control group consisted of subjects seen at the Ophthalmology Outpatient Clinic of this University Hospital with only eye refraction symptoms, and no other associated disease. Symptoms of anxiety were evaluated by the State-Trait Anxiety Inventory and symptoms of depression by the Beck Depression Inventory. Statistically significant differences were observed between patients with nephrolithiasis and controls for anxiety state (P = 0.001), anxiety trait (P = 0.005) and symptoms of depression (odds ratio = 3.74; 95%CI = 1.31-10.62). The Beck Depression Inventory showed 34.5% of respondents with moderate and 6% with severe levels of depression. There was a significant linear correlation between symptoms of anxiety (P = 0.002) and depression (P < 0.001) and the number of recurrent colic episodes (anxiety-state: P = 0.016 and anxiety-trait: P < 0.001). These data suggest an association between recurrent renal colic and symptoms of both anxiety and depression.

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Section: Introductionmentioning

confidence: 99%

Anxiety and depression symptoms in recurrent painful renal lithiasis colic

Diniz

Blay

Schor

2007

Braz J Med Biol Res

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“…This finding can be explained by the young ages of the cases and the low socioeconomic status of our region. In India, Ansari et al [16] have also reported the importance of socioeconomic status in the etiology and treatment of urolithiasis. This can be explained by the higher incidence of UTI, defective treatment and follow-up, lack of sufficient water and food intake which in the end result in dehydration and stone formation.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Demographic Characteristics of Children with Urolithiasis: Single-Center Experience from Eastern Turkey

2009

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Objective: To evaluate the clinical and demographic findings of children with urolithiasis in eastern Turkey. Methods: We retrospectively reviewed the medical records of 67 children with urolithiasis for clinical and laboratory data. Results: Mean age at the time of diagnosis was 39.1 ± 41.2 months. Complaints at admission were: urinary tract infection (29.9%), macroscopic hematuria (26.9%), abdominal or flank pain (19.4%), spontaneous passing of the stone (8.9%), growth and developmental delay (7.5%), and non-specific findings (8.9%). A family history of urolithiasis was positive in 50.7% of patients. Metabolic screening could be performed in 47 (70.1%) of patients due to socioeconomic problems and revealed hypercalciuria in 59.6%, infectious stone in 17%, cystinuria in 6.4%, hyperuricosuria in 10.6%, hyperoxaluria 4.3%, and hypocitruria in 2.1%. Stone analysis of patients (26.9%) revealed calcium oxalate in 38.9%, calcium phosphate in 22.2%, uric acid in 16.7%, cystine in 11.2%, struvite in 5.6% and mixed content in 5.6%. Conclusion: We believe early diagnosis with detailed metabolic screening and appropriate treatment and follow-up procedures and the contribution of urolithiasis to end-stage renal disease can be avoided.

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“…1 The lifetime prevalence of nephrolithiasis is between 5% and 12% in developed countries such as United States and most European states. 2 In developing countries, the incidence of stone disease is also increasing in particular as a consequence of hot climate in some geographical regions.…”

Section: Introductionmentioning

confidence: 99%

Proteomic changes in response to crystal formation inDrosophilaMalpighian tubules

Chung

Konietzny

Charles

et al. 2016

Fly

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Kidney stone disease is a major health burden with a complex and poorly understood pathophysiology. Drosophila Malpighian tubules have been shown to resemble human renal tubules in their physiological function. Herein, we have used Drosophila as a model to study the proteomic response to crystal formation induced by dietary manipulation in Malpighian tubules. Wild-type male flies were reared in parallel groups on standard medium supplemented with lithogenic agents: control, Sodium Oxalate (NaOx) and Ethylene Glycol (EG). Malpighian tubules were dissected after 2 weeks to visualize crystals with polarized light microscopy. The parallel group was dissected for protein extraction. A new method of Gel Assisted Sample Preparation (GASP) was used for protein extraction. Differentially abundant proteins (p<0.05) were identified by label-free quantitative proteomic analysis in flies fed with NaOx and EG diet compared with control. Their molecular functions were further screened for transmembrane ion transporter, calcium or zinc ion binder. Among these, 11 candidate proteins were shortlisted in NaOx diet and 16 proteins in EG diet. We concluded that GASP is a proteomic sample preparation method that can be applied to individual Drosophila Malpighian tubules. Our results may further increase the understanding of the pathophysiology of human kidney stone disease.

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Impact of Socioeconomic Status in Etiology and Management of Urinary Stone Disease

Cited by 32 publications

References 47 publications

Anxiety and depression symptoms in recurrent painful renal lithiasis colic

Anxiety and depression symptoms in recurrent painful renal lithiasis colic

Clinical and Demographic Characteristics of Children with Urolithiasis: Single-Center Experience from Eastern Turkey

Proteomic changes in response to crystal formation inDrosophilaMalpighian tubules

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