Impact of solar UV radiation on toxicity of ZnO nanoparticles through photocatalytic reactive oxygen species (ROS) generation and photo-induced dissolution

Hong, Ma; Wallis, Lindsay K.; Diamond, Steve; Li, Shibin; Cañas‐Carrell, Jaclyn E.; Parra, Amanda

doi:10.1016/j.envpol.2014.06.027

Cited by 125 publications

(50 citation statements)

References 38 publications

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“…It is reasonable to assume that the mechanisms by which NPs exert toxic effects on marine organisms are more complex than the mechanisms by which NPs exert toxic effects in freshwater. Therefore, findings from NP toxicity investigations in fresh water (Li et al, 2014a(Li et al, , 2014bMa et al, 2014;Zhao et al, 2013) must be taken into account but cannot be extrapolated to marine biota that exist in seawater.…”

Section: Introductionmentioning

confidence: 99%

Interaction of TiO 2 nanoparticles with the marine microalga Nitzschia closterium : Growth inhibition, oxidative stress and internalization

Xia

Chen

Sun

et al. 2015

Science of The Total Environment

230

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Section: Introductionmentioning

confidence: 99%

Interaction of TiO 2 nanoparticles with the marine microalga Nitzschia closterium : Growth inhibition, oxidative stress and internalization

Xia

Chen

Sun

et al. 2015

Science of The Total Environment

230

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“…This phenomenon can be explained probably due to the presence of ethanol, once ethanol may induce ROS production per se and due to the incomplete release of melatonin from PM2 (Helkin et al, 2010;Ma et al, 2014). Furthermore, some studies refer the cytotoxicity of ZnO nanoparticles, which may be associated not only with its action as an antibacterial, disinfecting and drying agent but also with its capacity to enhance ROS production (Ma et al, 2014). This suggests that the excipients of these formulations could have an oxidant activity, and that by themselves may induce ROS formation.…”

Section: Effect Of Melatonin On Generation Of Rosmentioning

confidence: 99%

Melatonin-based pickering emulsion for skin's photoprotection

et al. 2016

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Context: Based on its antioxidant activity, melatonin was recently found to have a protection effect against photocarcinogenesis. Objective: This work aimed to develop an innovative sunscreen formulation based on the Pickering emulsions concept, stabilized by physical UV filters, modified starch and natural oils associated to melatonin as a key strategy for prevention against UV-induced skin damage. Materials and methods: For this purpose, melatonin was incorporated in Pickering emulsions that were characterized using physicochemical, in vitro and in vivo testing. Physicochemical studies included physical and chemical stability by a thorough pharmaceutical control. The possible protective effects of melatonin against UV-induced cell damage in HaCaT cell lines were investigated in vitro. The safety assessment and the in vivo biological properties of the final formulations, including Human Repeat Insult Patch Test and sunscreen water resistance tests were also evaluated. Results and discussion: These studies demonstrated that melatonin sunscreen Pickering emulsion was beneficial and presented a powerful protection against UVB-induced damage in HaCat cells, including inhibition of apoptosis. The inclusion of zinc oxide, titanium dioxide, green coffee oil and starch ensured a high SPF (50+) against UVA and UVB. Conclusion: The combination of melatonin, multifunctional solid particles and green coffee oil, contributed to achieve a stable, effective and innovative sunscreen with a meaningful synergistic protection against oxidative stress.

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“…Oxidative stress can be defined as the state of imbalance between prooxidant challenge and antioxidant systems, attributing to the overproduction of ROS that exceed the capacity of antioxidant defense systems (Baysal et al, 2016;Li, Jiang, Cao, Xie, & Huang, 2017). Various environmental stresses are known to enhance the ROS production, such as ultraviolet radiation, heavy metals and pesticide remnant, disturbing the cellular redox homeostasis (Ma et al, 2014;Shahid et al, 2014;Thévenod, Friedmann, Katsen, & Hauser, 2000). Increase of ROS elicits a wide variety of physiological and cellular events, including lipid peroxidation, antioxidants' depletion, and DNA damage (Chen et al, 2012;She et al, 2016;Wang, Martínez, et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and DNA damage induced by spinosad exposure in Spodoptera frugiperda Sf9 cells

Yang

Gao

et al. 2017

Food and Agricultural Immunology

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Spinosad, a neurotoxic insecticide, is widely used for crop protection. In order to elucidate the effects of spinosad on oxidative stress and genotoxicity in Sf9 cells, the levels of lipid peroxidation, the activity of antioxidative enzymes, and DNA damage were measured. The results showed that spinosad caused a time-dependent increase in the formation of malondialdehyde and decrease in the activity of superoxide dismutase and catalase. Further studies confirmed that spinosad induced 8-oxoguanine accumulation in Sf9 cells, which is accompanied by increased expression of DNA repair enzymes (OGG1 and MTH1). The neutral comet assay revealed that spinosad induced significant timerelated increases of DNA double-strand breaks in Sf9 cells. Our results indicate that spinosad effectively induced oxidative stress and DNA damage in Sf9 cells. ARTICLE HISTORY

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Impact of solar UV radiation on toxicity of ZnO nanoparticles through photocatalytic reactive oxygen species (ROS) generation and photo-induced dissolution

Cited by 125 publications

References 38 publications

Interaction of TiO 2 nanoparticles with the marine microalga Nitzschia closterium : Growth inhibition, oxidative stress and internalization

Interaction of TiO 2 nanoparticles with the marine microalga Nitzschia closterium : Growth inhibition, oxidative stress and internalization

Melatonin-based pickering emulsion for skin's photoprotection

Oxidative stress and DNA damage induced by spinosad exposure in Spodoptera frugiperda Sf9 cells

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