Impact of sperm morphology on the likelihood of pregnancy after intrauterine insemination

Deveneau, Nicolette E.; Sinno, Omar; Krause, M.; Eastwood, Daniel; Sandlow, Jay; Robb, Paul; Granlund, Amy; Strawn, Estil

doi:10.1016/j.fertnstert.2014.09.016

Cited by 41 publications

(25 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…By detecting the fact that the success rate of pregnancy decreases when normal sperm morphology is <30% or motile sperm count is < 5x106 and the patient is a woman over 35, Badawy et al [5] pointed out in their study, which involved 714 IUI cycles and analyzed the effects of sperm count and morphology on the success of IUI, that morphology and motility are important. While these studies support our findings, Deveneau et al [13] argued in their retrospective study comprising 856 IUI cycles that sperm morphology lower than 4% was not related to low pregnancy rates of the patients undergoing IUI, and morphology could not be the only parameter to determine use of IVF method. Similarly, Krabinus and Gelety [14] did not identify any difference in the pregnancy rates even when the samples of morphology that were 4% or 30% worse than 4% were evaluated in their study of 538 IUI cycles.…”

Section: Discussionsupporting

confidence: 88%

The role of semen parameters in pregnancy of women having intrauterine insemination

Turhan¹

2018

Ann Clin Anal Med

View full text Add to dashboard Cite

Aim: To research the role of semen parameters in the likelihood of pregnancy of the couples with unexplained infertility who underwent intrauterine insemination. Material and Method: 545 cycles of IUI performed in our clinic due to unexplained infertility were included in the study. The IUI cycles were divided into two groups according to whether they achieved pregnancy: Group 1 pregnancy (77 cycles) and Group 2 non-pregnancy (468 cycles). Sperm parameters were statistically evaluated before and after the sperm washing. ROC (Receiver Operating Characteristic) analysis was performed to identify the effective cut-off values to predict pregnancy. P<0.05 was considered significant. Results: Morphology was observed to be statistically higher in the pregnant group than in the non-pregnant group before and after sperm washing (p=0.033 and p=0.028, respectively). No statistically significant difference was observed in any other parameters ( p>0.05). As a result of the pre-wash ROC analysis of sperm parameters, only morphology was found to be significant for the pregnancy to be predicted (p=0.029). When different cut-off values were analyzed in terms of morphology, the highest cut-off value in sensitivity and specificity was found to be 4.5. As a result of post-wash ROC analysis, it was detected that morphology, +4 and +3 values of sperm motility had statistically significant effects on the detection of pregnancy (p=0.029, p=0.020, and p=0.043, respectively). Other parameters were not observed to have any significant effects for the prediction of pregnancy (p>0.05). A cut-off value of 2.5 for post-wash morphology was found to have 92.9% sensitivity and 75.5% specificity. Discussion: Pre-and postwash morphology may affect the result of pregnancy by IUI in unexplained infertility. The cut-off values of morphology may predict the likelihood of pregnancy and this could allow advanced treatments to start sooner.

show abstract

Section: Discussionsupporting

confidence: 88%

The role of semen parameters in pregnancy of women having intrauterine insemination

Turhan¹

2018

Ann Clin Anal Med

View full text Add to dashboard Cite

show abstract

“…On the other hand, a recent study by Deveneau et al . showed that there is no statistically significant difference in ongoing pregnancy rate when comparing patients with strict sperm morphology ≤4% versus >4% in IUI cycles . According to our results, insemination performed at least 36 h after hCG administration may be beneficial for couples with either sperm morphology ≤4% or >4%.…”

Section: Discussionsupporting

confidence: 51%

Effect of insemination timing on pregnancy outcome in association with female age, sperm motility, sperm morphology and sperm concentration in intrauterine insemination

Lee

Hwang

Lee

et al. 2018

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…In another study Check et al divided patients into the three groups as sperm with normal morphology ratio <4%, 4-15% and >15% and obtained pregnancy rates as 30%, 26% and 20% respectively and they concluded that there was no positive correlation between pregnancy rate and morphological normal sperm ratio (13). Deveneau et al reported that there is no statistically significant difference in per cycle pregnancy rates when comparing patients with a strict sperm morphology of ≤4% versus >4% who undergo IUI (16). In our study we also observed that morphology alone does not result significant difference on pregnancy rate.…”

Section: Discussionmentioning

confidence: 99%

Effects of Sperm Parameters to Fertility for Intrauterine Insemination Patients According to WHO 2010 Criteria

Tursun

Görkemli²,

Yılmaz

et al. 2015

Electron J Gen Med

View full text Add to dashboard Cite

To evaluate sperm parameters as morphology of sperms in conjunction with number of motile sperms, according to 2010 World Health Organization (WHO) criteria's and to obtain optimal sperm parameters. We have examined prospectively 50 Intrauterine Insemination (IUI) cases for sperm parameters (morphology, TPMSC) and effects of some variables (woman age, infertility duration, FSH level, primary and secondary infertility) to pregnancy rate. First we divided cases in to 2 groups according to TPMSC (Total Progressive Motile Sperm Count) less than 1 million-greater than 1million-and compared number of progressively motile sperms and fertility rate. There was no statistically significant difference between pregnancy rate and sperm morphology (p>0.05)The pregnancy rate for the patient population with TPMSC >1million was more than another and this was statistically significant (p<0.05). There was no significant fertility difference among subgroups for Morphology and TPMSC as these 2 parameters are evaluated together (p>0.05). There was no significant difference according to age related pregnancy rate (p>0.05). There was no significant statistical differences among groups and subgroups in infertility duration, FSH level and woman age (p>0.05). Our study shows that pregnancy rate has no correlation with sperm morphology -as sperm parameter-for patients that IUI was applied.For the group with TPMSC >1 million, fertility rate was higher and this was statistically significant. Sperm parameters especially TPMSS that are important in determining the treatment plans of infertile patients but the effectiveness of morphology should be discussed. ÖZETÇalışmamızda sperm parametrelerinden morfoloji ve hareketli sperm sayısının birlikte ele alınarak 2010 WHO (Dünya Sağlık Örgütü) kriterleri'ne göre değerlendirip gebelik oranlarına etkilerini tespit ve optimal sperm parametrelerini elde etmeyi amaçladık. IUI uygulanan 50 hastada sperm parametrelerinin (morfoloji, TPMSS) ve bazı değişekenlerin (kadın yaşı, infertilite süresi, FSH değeri, primer ve sekonder infertilite) gebelik oranlarına etkilerini prospektif olarak inceledik. Çalışmamızda IUI sikluslarını ilk önce hastaları TPMSS'na göre <1milyon ve >=1milyon olarak iki gruba ayırıp gebelik oranlarını karşılaştırdık. Sperm morfolojisine göre de <%4 ve >=%4 olmak üzere 2 ayrı grup oluşturuldu ve gebelik oranları karşılaştırıldı. Sperm morfolojisi ile gebelik oranları arasında anlamlı istatistiksel fark izlenmedi(p>0.05). TPMSS>1 milyon olan hasta populasyonunda, gebelik oranları %45 olup TPMSS <1 milyon olan gruba göre (%10) istatistiksel olarak anlamlı oranda daha yüksek bulunmuştur (p<0.05). Çalışmamızda IUI uygulanan siklusları TPMSS <1milyon ve >=1milyon ve normal morfoloji <%4 ve >=%4 olarak birlikte değerlendirdiğimizde oluşan dört adet alt grub arasında kadın yaşı, infertilite süresi ve FSH değerleri ortalamaları arasındaki farklar istatistiksel olarak anlamlı değildi (p>0.05). Morfoloji ve TPMSS birlikte ele alındığında alt gruplar arasında gebelik oranları bakımından anlamlı ista...

show abstract

Impact of sperm morphology on the likelihood of pregnancy after intrauterine insemination

Cited by 41 publications

References 21 publications

The role of semen parameters in pregnancy of women having intrauterine insemination

The role of semen parameters in pregnancy of women having intrauterine insemination

Effect of insemination timing on pregnancy outcome in association with female age, sperm motility, sperm morphology and sperm concentration in intrauterine insemination

Effects of Sperm Parameters to Fertility for Intrauterine Insemination Patients According to WHO 2010 Criteria

Contact Info

Product

Resources

About