Impact of spray drying conditions on the reconstitution, efficiency and flow properties of spray dried apple powder-optimization, sensorial and rheological assessment

Qadri, Tahiya; Naik, Haroon Rashid; Hussain, Syed Zameer; Bhat, Tashooq Ahmad; Naseer, Bazila; Zargar, Imtiyaz Ahmad; Beigh, Mushtaq A.

doi:10.1016/j.heliyon.2023.e18527

Cited by 11 publications

(12 citation statements)

References 47 publications

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“…The DPPH radical scavenging assay is a simple, swift, cost-effective, and extensively used approach for evaluating antioxidant activity. Although the DPPH assay includes the transmission of hydrogen atoms, the primary chemical reaction is actually an electron transfer reaction [39]. In our study, the optimized formulation (APN2) showed potential antioxidant activity with similar results to ascorbic acid (standard).…”

Section: Dpph Radical Scavenging Activity Assaymentioning

confidence: 56%

“…These Angle of Repose values yield valuable insights into the flow characteristics of the SDSDs. For instance, APN2 stands out with the most favorable flow properties among the three batches, which can substantially contribute to enhanced manufacturability and the uniformity of dosage form production [39].…”

Section: Powder Characterization Angle Of Reposementioning

confidence: 99%

“…Hence, there was approximately a 1.69-fold increase in antioxidant activity for APN2 compared to pure APN. All the samples exhibited concentration-dependent activity [39]. The dissolution profiles of APN2 (3D printlet) and Mkd-APN were compared at various time points to assess their release behavior.…”

Section: Dpph Radical Scavenging Activity Assaymentioning

confidence: 99%

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Enhanced Apigenin Dissolution and Effectiveness Using Glycyrrhizin Spray-Dried Solid Dispersions Filled in 3D-Printed Tablets

Omer,

Fatima,

Ahmed

et al. 2023

Biomedicines

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This study aimed to prepare glycyrrhizin–apigenin spray-dried solid dispersions and develop PVA filament-based 3D printlets to enhance the dissolution and therapeutic effects of apigenin (APN); three formulations (APN1–APN3) were proportioned from 1:1 to 1:3. A physicochemical analysis was conducted, which revealed process yields of 80.5–91% and APN content within 98.0–102.0%. FTIR spectroscopy confirmed the structural preservation of APN, while Powder-XRD analysis and Differential Scanning Calorimetry indicated its transformation from a crystalline to an amorphous form. APN2 exhibited improved flow properties, a lower Angle of Repose, and Carr’s Index, enhancing compressibility, with the Hausner Ratio confirming favorable flow properties for pharmaceutical applications. In vitro dissolution studies demonstrated superior performance with APN2, releasing up to 94.65% of the drug and revealing controlled release mechanisms with a lower mean dissolution time of 71.80 min and a higher dissolution efficiency of 19.2% compared to the marketed APN formulation. This signified enhanced dissolution and improved therapeutic onset. APN2 exhibited enhanced antioxidant activity; superior cytotoxicity against colon cancer cells (HCT-116), with a lower IC50 than APN pure; and increased antimicrobial activity. A stability study confirmed the consistency of APN2 after 90 days, as per ICH, with an f2 value of 70.59 for both test and reference formulations, ensuring reliable pharmaceutical development. This research underscores the potential of glycyrrhizin–apigenin solid dispersions for pharmaceutical and therapeutic applications, particularly highlighting the superior physicochemical properties, dissolution behavior, biological activities, and stability of APN2, while the development of a 3D printlet shell offers promise for enhanced drug delivery and therapeutic outcomes in colon cancer treatment, displaying advanced formulation and processing techniques.

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Section: Dpph Radical Scavenging Activity Assaymentioning

confidence: 56%

Section: Powder Characterization Angle Of Reposementioning

confidence: 99%

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Enhanced Apigenin Dissolution and Effectiveness Using Glycyrrhizin Spray-Dried Solid Dispersions Filled in 3D-Printed Tablets

Omer,

Fatima,

Ahmed

et al. 2023

Biomedicines

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“…In the context of evaluating drying conditions on the physicochemical and functional characteristics of probiotic powdered umbu‐cajá pulp, it is essential to consider the water and total solids content as fundamental parameters. As highlighted by Qadri et al (2023), drying efficiency significantly impacts the water content, which in turn influences the physical, chemical stability, and overall acceptability of powdered products. Here, we present the water and total solids content of both fresh probiotic umbu‐cajá pulp and the selected powdered samples (Figure 3a), providing insights into the effects of different drying techniques and conditions on these crucial parameters.…”

Section: Resultsmentioning

confidence: 99%

Impact of drying technique on umbu‐cajá pulp with the addition of probiotic culture: Optimization, cell viability, physicochemical, and functional properties

Albuquerque,

Rodrigues,

da Silva

et al. 2024

Food Bioengineering

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This study aimed to assess the effects of spouted bed (SB) drying and freeze‐drying (FD) on the properties of probiotic umbu‐cajá pulp. The strain Bifidobacterium animalis ssp. lactis was employed to obtain this pulp. Initially, the study was conducted with two separate experimental designs, one for SB and another for FD, encompassing variables such as inlet temperature and concentrations of drying adjuvants (maltodextrin and inulin). This approach aimed to identify the most favorable conditions in terms of yield and cell viability. Both drying methods proved effective in preserving probiotic cells, with comparable viable cell counts (12 Log CFU g−1) and process yield of up to 30.68%. Additionally, FD exhibited advantages in preserving and increasing levels of bioactive compounds, including phenolics and carotenoids, in the final product. In contrast, SB drying stood out for retaining carotenoids and exhibiting lower degradation of ascorbic acid. In summary, this study demonstrated that both SB drying and FD are promising approaches in producing powders from probiotic umbu‐cajá pulp. However, the selection between the methods should be guided by specific production goals, considering the desired characteristics of the final product.

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“…It can be seen that the moisture content of spray-dried powder using maltodextrin (6.59%-7.75%) is significantly higher than the carrier blend (GA-MD) samples (2.18%) while their solubility are all relatively high (77.06%-84.33%). This may be due to the chemical structure of maltodextrin, which has many hydrophilic groups and low glass transition temperature, and the amorphous nature of maltodextrin under high relative humidity storage conditions, which increases the stickiness of the powder by absorbing moisture (Mahdavi et al, 2016;Qadri et al, 2023). Moisture content of less than 5% or 0.04 kg water/kg solids is ideal for storage and the survival of microorganisms (Pinto et al, 2019;Jiang et al, 2020).…”

Section: Physical Propertiesmentioning

confidence: 99%

Development of dairy‐free soybean‐based yoghurt by active dry starter culture from kombucha: an investigation into microencapsulation, curd formation, protein and texture profiles during storage

Nguyen,

Do,

Phan Van

et al. 2024

Int J of Food Sci Tech

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SummaryIncreasing demand for the production and use of non‐dairy products has resulted from the rapid increase of vegetarian and lactose‐intolerant populations. In this study, non‐dairy yoghurt was developed from soybeans using microencapsulated starter culture consisting of Levilactobacillus brevis and Saccharomyces cerevisiae isolated from kombucha based on spray drying and freeze drying techniques using 20% maltodextrin (MD) and gum Arabic‐maltodextrin mixture (GA‐MD) as carriers. Scanning electron microscopy revealed high integrity and effective microbial protection within the carrier matrices, especially for freeze‐dried samples with L. brevis density being in the range of 6.1–6.4 log CFU/g. During 21‐day storage of microcapsules at 4 °C, L. brevis density decreased to 4.4–5.1 log CFU/g for all carriers while GA‐MD was incapable of preserving its viability at 30 °C. Meanwhile, the soybean‐based yoghurt was produced using these four microcapsules as active dry starter culture for the investigation of warm incubation/curd formation and subsequent refrigeration. Regarding warm incubation, in contrast to conventional yoghurt, there was no drop in pH or total acidity over the first 7–8 h of storage, followed by their sudden decline which led to the curd formation in the next hour at pH and total acidity of 5.42–5.75 and 2.29–3.06 g lactic acid/L respectively. Furthermore, GA‐MD samples exhibited more severe syneresis and surface cracks than MD during refrigeration in which the hardness and gumminess of yoghurt increased over time. Electrophoresis results also confirmed the proteolytic activity of lactic acid bacteria and yeast on β‐conglycinin and glycinin fractions of soy proteins.

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Impact of spray drying conditions on the reconstitution, efficiency and flow properties of spray dried apple powder-optimization, sensorial and rheological assessment

Cited by 11 publications

References 47 publications

Enhanced Apigenin Dissolution and Effectiveness Using Glycyrrhizin Spray-Dried Solid Dispersions Filled in 3D-Printed Tablets

Enhanced Apigenin Dissolution and Effectiveness Using Glycyrrhizin Spray-Dried Solid Dispersions Filled in 3D-Printed Tablets

Impact of drying technique on umbu‐cajá pulp with the addition of probiotic culture: Optimization, cell viability, physicochemical, and functional properties

Development of dairy‐free soybean‐based yoghurt by active dry starter culture from kombucha: an investigation into microencapsulation, curd formation, protein and texture profiles during storage

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