Impact of stent implantation on endothelial shear stress

Economou, F.; Katranas, Sotirios; Giannoglou, George D.; Gemitzis, Konstantinos D.; Styliadis, Ioannis H.; Efthimiadis, Georgios K.; Karvounis, Haralambos; Ziakas, Antonis

doi:10.1007/s00059-016-4487-4

Cited by 3 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A ATC coronária é um procedimento invasivo não cirúrgico feito através de um cateter afim de implantar um stent na artéria, desobstruir a coronária e restabelecer o fluxo sanguíneo. Estudos mostram que a intervenção percutânea causa danos às células endoteliais, o que promove a reestenose intra-stent (92,93). Migração e proliferação de células endoteliais podem causar o reparo no dano(92).…”

Section: Tratamentounclassified

Efeito do treinamento físico em pacientes submetidos à angioplastia coronariana eletiva: avaliação dos biomarcadores inflamatórios sanguíneos e fluxo sanguíneo periférico endotélio-dependente

Correia¹

View full text Add to dashboard Cite

Section: Tratamentounclassified

Efeito do treinamento físico em pacientes submetidos à angioplastia coronariana eletiva: avaliação dos biomarcadores inflamatórios sanguíneos e fluxo sanguíneo periférico endotélio-dependente

Correia¹

View full text Add to dashboard Cite

Influence of angioplasty and stenting on intracranial artery stenosis: preliminary results of high-resolution vessel wall imaging evaluation

Chung

Chen

et al. 2022

Eur Radiol

View full text Add to dashboard Cite

Design Considerations and Flow Characteristics for Couette-Type Blood-Shear Devices

Chen,

Avital,

Imran

et al. 2024

Fluids

View full text Add to dashboard Cite

Cardiovascular prosthetic devices, stents, prosthetic valves, heart-assist pumps, etc., operate in a wide regime of flows characterized by fluid dynamic flow structures, laminar and turbulent flows, unsteady flow patterns, vortices, and other flow disturbances. These flow disturbances cause shear stress, hemolysis, platelet activation, thrombosis, and other types of blood trauma, leading to neointimal hyperplasia, neoatherosclerosis, pannus overgrowth, etc. Couette-type blood-shearing devices are used to simulate and then clinically measure blood trauma, after which the results can be used to assist in the design of the cardiovascular prosthetic devices. However, previous designs for such blood-shearing devices do not cover the whole range of flow shear, Reynolds numbers, and Taylor numbers characteristic of all types of implanted cardiovascular prosthetic devices, limiting the general applicability of clinical data obtained by tests using different blood-shearing devices. This paper presents the key fluid dynamic parameters that must be met. Based on this, Couette device geometric parameters such as diameter, gap, flow rate, shear stress, and temperature are carefully selected to ensure that the device’s Reynolds numbers, Taylor number, operating temperature, and shear stress in the gap fully represent the flow characteristics across the operating range of all types of cardiovascular prosthetic devices. The outcome is that the numerical data obtained from the presented device can be related to all such prosthetic devices and all flow conditions, making the results obtained with such shearing devices widely applicable across the field. Numerical simulations illustrate that the types of flow patterns generated in the blood-shearing device meet the above criteria.

show abstract

Impact of stent implantation on endothelial shear stress

Abstract: ESS decreases after stent implantation but not uniformly, with the major reduction being in the middle tertile of the stent, and distal to the stent. In-stent ESS decrease may create local hemodynamic conditions leading to in-stent and in-segment restenosis.

Cited by 3 publications

References 15 publications

Efeito do treinamento físico em pacientes submetidos à angioplastia coronariana eletiva: avaliação dos biomarcadores inflamatórios sanguíneos e fluxo sanguíneo periférico endotélio-dependente

Efeito do treinamento físico em pacientes submetidos à angioplastia coronariana eletiva: avaliação dos biomarcadores inflamatórios sanguíneos e fluxo sanguíneo periférico endotélio-dependente

Influence of angioplasty and stenting on intracranial artery stenosis: preliminary results of high-resolution vessel wall imaging evaluation

Design Considerations and Flow Characteristics for Couette-Type Blood-Shear Devices

Contact Info

Product

Resources

About