Impact of sterilization treatments on biodegradability and cytocompatibility of zinc-based implant materials

Li, Ping; Zhang, Wentai; Spintzyk, Sebastian; Schweizer, Ernst; Krajewski, Stefanie; Alexander, Dorothea; Dai, Jingtao; Xu, Shulan; Wan, Guojiang; Rupp, Frank

doi:10.1016/j.msec.2021.112430

Cited by 10 publications

(9 citation statements)

References 72 publications

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“…Jablonska et al confirmed the effect of FBS (fetal bovine serum) in the cell medium on cytotoxicity tests [15,83]. The effect of pretreatments such as pre-cultivation, stabilization treatment [91], sterilization treatment [75], sandblasting [93], and acid etching treatment [102] was also investigated.…”

Section: Test Systemmentioning

confidence: 97%

“…The cells in the cell culture medium alone and supplemented with 5-20% dimethyl sulfoxide (DMSO) were usually chosen as negative and positive control groups, respectively. Some researchers also used Cu and Ti-6Al-4V alloy as negative and positive controls, respectively [59,[73][74][75][76]83,93]. Five studies used the culture medium supplemented with 0.64% phenol as a positive control [21,35,45,52,63].…”

Section: Test Systemmentioning

confidence: 99%

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Cytotoxicity of Biodegradable Zinc and Its Alloys: A Systematic Review

Liu

et al. 2023

JFB

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Zinc-based biodegradable metals (BMs) have been developed for biomedical implant materials. However, the cytotoxicity of Zn and its alloys has caused controversy. This work aims to investigate whether Zn and its alloys possess cytotoxic effects and the corresponding influence factors. According to the guidelines of the PRISMA statement, an electronic combined hand search was conducted to retrieve articles published in PubMed, Web of Science, and Scopus (2013.1–2023.2) following the PICOS strategy. Eighty-six eligible articles were included. The quality of the included toxicity studies was assessed utilizing the ToxRTool. Among the included articles, extract tests were performed in 83 studies, and direct contact tests were conducted in 18 studies. According to the results of this review, the cytotoxicity of Zn-based BMs is mainly determined by three factors, namely, Zn-based materials, tested cells, and test system. Notably, Zn and its alloys did not exhibit cytotoxic effects under certain test conditions, but significant heterogeneity existed in the implementation of the cytotoxicity evaluation. Furthermore, there is currently a relatively lower quality of current cytotoxicity evaluation in Zn-based BMs owing to the adoption of nonuniform standards. Establishing a standardized in vitro toxicity assessment system for Zn-based BMs is required for future investigations.

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Section: Test Systemmentioning

confidence: 97%

Section: Test Systemmentioning

confidence: 99%

Cytotoxicity of Biodegradable Zinc and Its Alloys: A Systematic Review

Liu

et al. 2023

JFB

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“…In this particular case study, gamma irradiation and H2O2 gas plasma treatment were used, which did not alter significantly the surface characteristics and chemical composition of the Zn or Zn alloy [23].…”

Section: Figure 7 Roughness Measurement Curve After Millingmentioning

confidence: 99%

Reconstruction of Orbital Wall by Using Hybrid Manufacturing Operations

Pascu

Bâlc

Pop

2022

IOP Conf. Ser.: Mater. Sci. Eng.

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This paper will discuss the solutions and the main parameters used to print a mold that will be used in a manufacturing process for a personalized implant in orbital fracture situations. The main purpose of this article is to rebuild the damaged orbit. The new orbit should have dimensions and accuracy similar to one of the original elements. Based on the computed tomography (CT) of the patient, the images are extracted and processed. With that information, a customized implant is manufactured. In this article, a case study of a patient suffering from an orbital fracture is presented. Based on the CT images, a mold was printed on additive manufacturing equipment (AM). The manufacturing parameters being highly correlated with the requirements that are needed for this case such as hardness, accuracy, surface roughness and support removal were chosen based on a series of tests and results from other studies. Another aspect that was analysed was related to the material from which was manufactured the mold. The forming and cutting of the mesh are simplified, by introducing the formed metallic mesh making it ready to be applied to real patients and therefore decreasing the effective time required for this kind of operation.

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“…Numerous in vitro studies have shown that Zn-based implants exhibit severe cytotoxicity to cells. [19,20] Based on this, studies of Zn-based implants need to be performed to realize the perfect performance. Therefore, it is of great significance to explore the material preparation method to reduce the cytotoxicity of Zn alloys.…”

Section: Introductionmentioning

confidence: 99%

Calcium–Zinc Phosphate Chemical Conversion Coating Facilitates the Osteointegration of Biodegradable Zinc Alloy Implants by Orchestrating Macrophage Phenotype

Zhao

Zuo

et al. 2023

Adv Healthcare Materials

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Zinc (Zn) alloys provide a new generation for orthopedic applications due to their essential physiological effects and promising degradation properties. However, excessive release of Zn ions (Zn2+) during degradation and the severe inflammatory microenvironment are not conducive to osseointegration, which is determined by the characteristics of the implant surface. Therefore, it is essential to modulate the release rate of Zn alloys by surface modification technology and endow them with anti‐inflammatory and osteogenic effects. In this study, two kinds of phosphate chemical conversion (PCC) coatings with different compositions and morphological structures are prepared, namely Zn–P (with disk‐like crystals) and Ca–Zn–P (with lamellar crystals). Although all the PCC‐coated Zn implants have low cytotoxicity, Ca–Zn–P show better osteoimmunomodulation effects in several aspects: the induction of the M2‐phenotype macrophage polarization and thus promotion of osteogenesis in vitro; the regulation of the bone immune microenvironment which is conducive to tissue regeneration and osseointegration in vivo; and the release of ions (through PI3K/AKT and Wnt signaling pathways) and the morphological structures (through RhoGTPase signaling pathways) act as possible mechanisms of M2 polarization. The Ca–Zn–P coating can be considered to provide new insights into bone immunomodulation and osseointegration.

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Impact of sterilization treatments on biodegradability and cytocompatibility of zinc-based implant materials

Cited by 10 publications

References 72 publications

Cytotoxicity of Biodegradable Zinc and Its Alloys: A Systematic Review

Cytotoxicity of Biodegradable Zinc and Its Alloys: A Systematic Review

Reconstruction of Orbital Wall by Using Hybrid Manufacturing Operations

Calcium–Zinc Phosphate Chemical Conversion Coating Facilitates the Osteointegration of Biodegradable Zinc Alloy Implants by Orchestrating Macrophage Phenotype

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