Impact of subthalamic nucleus stimulation did not differ on young-onset and older-onset Parkinson's disease: A three-year follow up

Zhang, Junmei; Jia, Ge; Yang, Zhiyong; Liu, Dingyang; Hou, Yonghong; Wang, Yanjin; Yang, Zhiquan

doi:10.1016/j.neulet.2019.04.041

Cited by 2 publications

(5 citation statements)

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“…Several studies have reported that patients with YOPD and LOPD demonstrate reductions in UPDRS III scores. [17][18][19][20][21][22][23]45] Vesper et al [46] showed that there is no significant difference in the quality of life after STN DBS between young and old patients with PD during follow-up or improvement in motor symptoms. This was a result of little improvement in cognitive function and was not caused by differences in motor symptom improvement after DBS.…”

Section: Discussionmentioning

confidence: 99%

“…Vats et al [ 19 ] and Bouwyn et al [ 28 ] added a comparison of changes in cognitive function, Derost et al [ 24 ] compared changes in quality of life, and Zhang et al [ 18 ] and Chiou et al [ 25 ] added a comparative analysis of reduction in daily levodopa equivalent dose. Shalash et al [ 17 ] showed that the duration of the disease does not differ in UPDRS III score, but there is a difference in dyskinesia.…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19]24,25,28] Four studies divided the patients into 2 groups with an age cutoff of 65 years, [17,19,24,28] one study with an age cutoff of 70 years, [25] and one study with an age cutoff of 50 years. [18] All patients were on medication with levodopa. The detailed procedure for inclusion is shown in Figure 1, and the study characteristics are summarized in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…After reviewing the full text of the remaining 14 articles, 6 studies were eligible for inclusion. [17][18][19]24,25,28] Four studies divided the patients into 2 groups with an age cutoff of 65 years, [17,19,24,28] one study with an age cutoff of 70 years, [25] and one study with an age cutoff of 50 years. [18] All patients were on medication with levodopa.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Several studies have reported that DBS shows good results in both YOPD and LOPD. [17][18][19][20][21][22][23] However, there are studies showing that DBS has a different effect on each group. Some studies have shown that DBS is more effective in improving the quality of life in YOPD than LOPD, [24,25] whereas another study has reported that there is less acute improvement from acute DBS than LOPD.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of UPDRS III score between young and late onset Parkinson disease after deep brain stimulation: A meta-analysis

Lee,

Pak

2023

Medicine

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Purpose: Parkinson disease (PD) is a common age-related neurodegenerative disease. Subthalamic nucleus deep brain stimulation (DBS) is a safe and effective surgical treatment for medically resistant advanced PD. However, the relationship between the age at PD onset and the efficacy of subthalamic nucleus DBS surgery remains unclear. Thus, we conducted a meta-analysis to compare motor symptom improvements after DBS for the treatment of young-onset and late-onset PD. Methods: We systematically searched the Medline and Embase databases (from inception to March 2023) for English publications. All published studies comparing the outcomes (Unified Parkinson’s Disease Rating Scale part III [UPDRS III] scores) of DBS between the young-onset Parkinson disease (YOPD) and late-onset Parkinson disease (LOPD) groups were identified. The effect size was defined as the standardized mean difference (Hedge g) with 95% confidence intervals. The standardized mean difference was calculated by dividing the difference in UPDRS III scores between old and young patients by the pooled and weighted standard deviations. The meta-analysis was performed using R Statistical Software version 4.2.2 (The R Foundation for Statistical Computing). Results: Six studies were eligible for inclusion. The standardized mean difference of UPDRS III score between young and old patients ranged from −0.54 to 1.43 with a pooled difference of 0.0932 (95% confidence intervals: − 0.4666 to 0.6530, I 2 = 86.77%). Subgroup analyses were performed with a cutoff age of 65 years and did not show a significant difference in UPDRS III scores between patients with YOPD and LOPD (0.1877, −0.6663 to 1.0417). Conclusions: The efficacy of DBS in patients with YOPD and LOPD showed similar improvements in the UPDRS score; hence, DBS should be considered, if necessary, regardless of the onset age of PD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of UPDRS III score between young and late onset Parkinson disease after deep brain stimulation: A meta-analysis

Lee,

Pak

2023

Medicine

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Preoperative Levodopa Response and Deep Brain Stimulation Effects on Motor Outcomes in Parkinson's Disease: A Systematic Review

Lin

Zhang

et al. 2021

Movement Disord Clin Pract

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Background The up‐to‐date literature systematically reviewing the predictive value of preoperative levodopa responsiveness after deep brain stimulation (DBS) surgery in motor outcomes in Parkinson's disease (PD) is lacking. Objective To address this issue in patients with PD undergoing bilateral subthalamic nucleus (STN) or globus pallidus interna (GPi) DBS. Methods We used the existing PRISMA consensus statement. A comprehensive review of literature from 1993 to May 2021 retrieved from PubMed was conducted. Results The STN‐DBS responsiveness was significantly correlated with the preoperative levodopa responsiveness for the total score of UPDRS‐III at both 6‐ and 12‐month follow‐ups (P < 0.001). Such correlations were significant after controlling for age at time of surgery and disease duration. The significance of correlation disappeared for longer follow‐up times. For the sub‐scores of UPDRS‐III, a significant correlation between the preoperative levodopa responsiveness and STN DBS responsiveness was observed for rigidity, bradykinesia, and axial symptoms, but not for tremor (P = 0.002, 0.010, 0.007, and 0.542, respectively). The preoperative levodopa responsiveness was significantly correlated with GPi DBS responsiveness for the UPDRS‐III total score at a median follow‐up of 12 months (P = 0.030). Conclusion The current study confirmed the value of preoperative levodopa responsiveness for prediction of the short‐term motor outcome after DBS (for both STN and GPi). The predictive value of levodopa responsiveness in short‐term outcomes for respective cardinal motor disabilities and the loss of its predictive value after STN DBS for long‐term motor outcomes were highlighted by this study.

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Impact of subthalamic nucleus stimulation did not differ on young-onset and older-onset Parkinson's disease: A three-year follow up

Cited by 2 publications

References 26 publications

Comparison of UPDRS III score between young and late onset Parkinson disease after deep brain stimulation: A meta-analysis

Comparison of UPDRS III score between young and late onset Parkinson disease after deep brain stimulation: A meta-analysis

Preoperative Levodopa Response and Deep Brain Stimulation Effects on Motor Outcomes in Parkinson's Disease: A Systematic Review

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