Impact of supplemental vitamin D3 and calcium on hypercholesterolemia

Abstract

Aim:In the present crossover study, we aimed to assess if calcium and vitamin D can help statins for treatment of hypercholesterolemia. Method: This crossover study was conducted on 60 participants with newly diagnosed hypercholesterolemia. In first phase of study, all patients were administered one 20-mg tablet of atorvastatin every bedtime for sex weeks. Thereafter, in the second phase, all participants received 400 IU vitamin D3 and 1000 mg calcium in addition to previous regimen. After each phase, Lipid profile was evaluated for all participants. Results: 60 individuals including 26 men (43.3%) and 34 women (56.7%) participated in this study. There was significant decrease in triglyceride, total cholesterol and LDL after six weeks treatment with atorvastatin. However, HDL showed no significant change. When blood lipid values after statin therapy was compared to the values after treatment with atorvastatin plus supplemental calcium and vitamin D3, none showed statistically significant change. BMI was found to decrease significantly in both phase of treatment, but blood pressure showed no change. Conclusion: In summary, we observed that supplemental calcium and vitamin D3 have no significant impact on lipid profile and blood pressure. However, we found that supplemental calcium and vitamin D3 decreased BMI, but more studies are in need to support our results.

Serum Cholesterol Differences Between Statin Users Who Take Dietary Supplements and Those Who Do Not: NHANES 2013–2018

“…The concurrent use of statins and dietary supplements may increase the potential for drug–nutrient interactions. However, the exploration of the efficacy of statins in serum cholesterol management during concurrent use of dietary supplements is limited [ [25] , [26] , [27] , [28] , [29] , [30] , [31] , 46 , 47 ]. To the best of our knowledge, this is the first cross-sectional study of its kind that assessed the mean differences in the serum levels of lipids between those who take statin drugs and dietary supplements and those who take statins alone.…”

“…Vitamin D in all its metabolite forms, except 1,25-dihydroxyvitamin D 3 , inhibits HMG-CoA reductase activity, reducing the biosynthesis of hepatic cholesterol and circulating cholesterol levels in vitro [ 48 ]. The effect of vitamin D on the pharmacodynamics and pharmacokinetics of statins has been tested in clinical trials [ 26 , 31 , 46 , 47 , 49 ]. However, the results were not consistent [ 46 , 47 ].…”

“…The effect of vitamin D on the pharmacodynamics and pharmacokinetics of statins has been tested in clinical trials [ 26 , 31 , 46 , 47 , 49 ]. However, the results were not consistent [ 46 , 47 ]. CoQ10 is a fat-soluble organic molecule that works in the electron transport chain, converting food to energy, and its deficiency is common in myocardial biopsies from various CVD events [ 50 ].…”