Impact of surfactant selection and incorporation on in situ nanoparticle formation from amorphous solid dispersions

Yen, Chun-Wan; Kuhn, Robert J.; Hu, Chloe; Zhang, Wei; Chiang, Po‐Chang; Chen, Jacob Z.; Hau, Jonathan; Estevez, Alberto; Nagapudi, Karthik; Leung, Dennis

doi:10.1016/j.ijpharm.2021.120980

Cited by 10 publications

(9 citation statements)

References 36 publications

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“…In a study by Yan et al [ 93 ], the non-ionic surfactants Tween 80, Vitamin E TPGS, and anionic surfactants such as sodium lauryl sulfate(SLS) were investigated in the formation of in situ nano particles. ASDs was manufactured using NCE GDC-0334 with co-povidone and surfactants by spray-drying.…”

Section: Advances In Asd Formulation Approachesmentioning

confidence: 99%

Recent Advances in Amorphous Solid Dispersions: Preformulation, Formulation Strategies, Technological Advancements and Characterization

et al. 2022

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Amorphous solid dispersions (ASDs) are among the most popular and widely studied solubility enhancement techniques. Since their inception in the early 1960s, the formulation development of ASDs has undergone tremendous progress. For instance, the method of preparing ASDs evolved from solvent-based approaches to solvent-free methods such as hot melt extrusion and Kinetisol®. The formulation approaches have advanced from employing a single polymeric carrier to multiple carriers with plasticizers to improve the stability and performance of ASDs. Major excipient manufacturers recognized the potential of ASDs and began introducing specialty excipients ideal for formulating ASDs. In addition to traditional techniques such as differential scanning calorimeter (DSC) and X-ray crystallography, recent innovations such as nano-tomography, transmission electron microscopy (TEM), atomic force microscopy (AFM), and X-ray microscopy support a better understanding of the microstructure of ASDs. The purpose of this review is to highlight the recent advancements in the field of ASDs with respect to formulation approaches, methods of preparation, and advanced characterization techniques

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Section: Advances In Asd Formulation Approachesmentioning

confidence: 99%

Recent Advances in Amorphous Solid Dispersions: Preformulation, Formulation Strategies, Technological Advancements and Characterization

et al. 2022

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“…Surfactants added to ASD formulations may also influence the LLPS [238] , [239] , [240] . Taylor and coworkers evaluated the impacts of surfactants on the processability and release rates of clopidogrel ASDs.…”

Section: Formulation Design Of Asdsmentioning

confidence: 99%

Advances in the development of amorphous solid dispersions: The role of polymeric carriers

Zhang,

Guo,

Luo

et al. 2023

Asian Journal of Pharmaceutical Sciences

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“…The nanoformulation forms amorphous solid dispersion with surfactant Tween 80 and increases plasma concentrations of 40 levels in rats. [102] Moreover, the TRPV1 agonist, capsaicin ( 16) is encapsulated with high-amylose corn starch to increase the bioavailability. [103] These systems, as well as the recent machine-learning technology that predict the optimal excipient for drugs, [104] hold great promise for optimization of dispersion and solubility of drugs against TRP channels.…”

Section: Nanoformulations Increase the Solubility Of Trpa1 Ligandsmentioning

confidence: 99%

“…Yet its poor solubility stimulates the development of nanoformulation of 40 . The nanoformulation forms amorphous solid dispersion with surfactant Tween 80 and increases plasma concentrations of 40 levels in rats [102] …”

Section: Decreasing the Hydrophobicity Of Trp Ligandsmentioning

confidence: 99%

Multidisciplinary Advances Address the Challenges in Developing Drugs against Transient Receptor Potential Channels to Treat Metabolic Disorders

Wang

2023

ChemMedChem

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Transient receptor potential (TRP) channels are cation channels that regulate key physiological and pathological processes in response to a broad range of stimuli. Moreover, they systemically regulate the release of hormones, metabolic homeostasis, and complications of diabetes, which positions them as promising therapeutic targets to combat metabolic disorders. Nevertheless, there are significant challenges in the design of TRP ligands with high potency and durability. Herein we summarize the four challenges as hydrophobicity, selectivity, mono‐target therapy, and interspecies discrepancy. We present 1134 TRP ligands with diversified modes of TRP‐ligand interaction and provide a detailed discussion of the latest strategies, especially cryogenic electron microscopy (cryo‐EM) and computational methods. We propose solutions to address the challenges with a critical analysis of advances in membrane partitioning, polypharmacology, biased agonism, and biochemical screening of transcriptional modulators. They are fueled by the breakthrough from cryo‐EM, chemoinformatics and bioinformatics. The discussion is aimed to shed new light on designing next‐generation drugs to treat obesity, diabetes and its complications, with optimal hydrophobicity, higher mode selectivity, multi‐targeting and consistent activities between human and rodents.

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Impact of surfactant selection and incorporation on in situ nanoparticle formation from amorphous solid dispersions

Cited by 10 publications

References 36 publications

Recent Advances in Amorphous Solid Dispersions: Preformulation, Formulation Strategies, Technological Advancements and Characterization

Recent Advances in Amorphous Solid Dispersions: Preformulation, Formulation Strategies, Technological Advancements and Characterization

Advances in the development of amorphous solid dispersions: The role of polymeric carriers

Multidisciplinary Advances Address the Challenges in Developing Drugs against Transient Receptor Potential Channels to Treat Metabolic Disorders

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