Impact of Surgical Resection and Reasons for Poor Prognosis of Pelvic Osteosarcoma Based on the Bone Tumor Registry in Japan

Abstract

Pelvic osteosarcoma has a poor prognosis compared to osteosarcomas in other locations, and the reasons for this remain unknown. Surgical resection of pelvic osteosarcoma is technically demanding and often results in dysfunction and complications. In this study, we investigated the reasons underlying the poor prognosis of pelvic osteosarcoma by comparing it to femoral osteosarcoma using data from the Bone Tumor Registry in Japan. We used propensity score analysis to determine whether surgical resection of pelvic osteosarcoma improved its prognosis. We demonstrated that pelvic osteosarcoma had a poor prognosis because it occurred more often in the elderly, often had larger tumor size, and had metastasis at presentation more often in comparison to femoral osteosarcoma. These three factors were also associated with the non-surgical treatment of pelvic osteosarcoma, which also led to a poor outcome. The overall survival rate was only comparable in pelvic osteosarcoma and femoral osteosarcoma in cases treated with surgical resection. Propensity score analysis revealed that surgical treatment improved the prognosis of pelvic osteosarcoma. As such, we propose that surgical resection should be considered based on tumor stage and patient age in order to improve the prognosis of pelvic osteosarcoma.

Cancer-Specific Survival after Limb Salvage versus Amputation in Children and Adolescents with Osteosarcoma: A Population-Based Analysis with Propensity Score Matching

“…Numerous studies have reported that as the height of an individual increases so does the risk of OS [ 17 – 19 ]. Pelvic osteosarcoma has a substantially worse prognosis than osteosarcoma of the extremities [ 20 ]. This study also confirmed the AJCC stage was an independent risk factor that affected the prognosis of OS patients.…”

Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases

“…Osteosarcoma is the most common primary bone tumor in children and young adults (104)(105)(106)(107)(108). However, the overall survival of patients with osteosarcoma remains unfavorable despite attempts to improve the efficacy of chemotherapy (109)(110)(111). Recent studies have proposed that targeting lncRNAs may provide a novel insight into the treatment of osteosarcoma (112)(113)(114)(115).…”

Artificial neural network‐based gene screening and immune cell infiltration analysis of osteosarcoma feature

“…The prognosis for OS patients with axial bone site affliction, such as the spine and pelvis, is considerably poorer compared to their counterparts suffering from limb‐related OS. Patients with metastases in the lungs or other regions, along with those exhibiting inadequate response to chemotherapy, tend to have a dismal prognosis 5,6 . Consequently, there is an exigent requirement for devising precise and dependable biological methodologies for predicting OS diagnosis and prognosis.…”

“…Patients with metastases in the lungs or other regions, along with those exhibiting inadequate response to chemotherapy, tend to have a dismal prognosis. 5,6 Consequently, there is an exigent requirement for devising precise and dependable biological methodologies for predicting OS diagnosis and prognosis.…”